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'''RhoH''' (Ras homolog gene family, member H) is a small (~21 kDa) signaling [[G protein]] (more specifically a [[GTPase]]), and is a member of the [[Rac protein|Rac]] subfamily of the family [[Rho family of GTPases]].<ref name=Ridley>{{cite journal | vauthors = Ridley AJ | title = Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking | journal = Trends in Cell Biology | volume = 16 | issue = 10 | pages = 522–9 | date = October 2006 | pmid = 16949823 | doi = 10.1016/j.tcb.2006.08.006 }}</ref> It is encoded by the gene '''RHOH'''.<ref name="entrez">{{cite web | title = Entrez Gene: RHOH ras homolog gene family, member H| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=399| accessdate = }}</ref> | |||
}} | |||
==Gene== | |||
Expression of a chimeric transcript of LAZ3 and this gene has been reported as a result of the translocation t(3;4) in [[non-Hodgkin's lymphoma]]s. Unlike most other small G proteins which are expressed ubiquitously, this gene is transcribed only in [[hemopoietic cell]]s.<ref name="entrez"/> | |||
== | == Interactions == | ||
== | RhoH has been shown to [[Protein-protein interaction|interact]] with [[ARHGDIA]].<ref name=pmid11809807>{{cite journal | vauthors = Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B | title = The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function | journal = Molecular and Cellular Biology | volume = 22 | issue = 4 | pages = 1158–71 | date = February 2002 | pmid = 11809807 | pmc = 134637 | doi = 10.1128/MCB.22.4.1158-1171.2002 }}</ref><ref name=pmid11368848>{{cite journal | vauthors = Fauré J, Dagher MC | title = Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI) | journal = Biochimie | volume = 83 | issue = 5 | pages = 409–14 | date = May 2001 | pmid = 11368848 | doi = 10.1016/S0300-9084(01)01263-9 }}</ref> | ||
{{ | |||
== | == References == | ||
{{ | {{Reflist}} | ||
{{protein- | == Further reading == | ||
{{Refbegin | 2}} | |||
* {{cite journal | vauthors = Dallery E, Galiègue-Zouitina S, Collyn-d'Hooghe M, Quief S, Denis C, Hildebrand MP, Lantoine D, Deweindt C, Tilly H, Bastard C | title = TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation | journal = Oncogene | volume = 10 | issue = 11 | pages = 2171–8 | date = June 1995 | pmid = 7784061 | doi = }} | |||
* {{cite journal | vauthors = Dallery-Prudhomme E, Roumier C, Denis C, Preudhomme C, Kerckaert JP, Galiegue-Zouitina S | title = Genomic structure and assignment of the RhoH/TTF small GTPase gene (ARHH) to 4p13 by in situ hybridization | journal = Genomics | volume = 43 | issue = 1 | pages = 89–94 | date = July 1997 | pmid = 9226377 | doi = 10.1006/geno.1997.4788 }} | |||
* {{cite journal | vauthors = Yousefi S, Cooper PR, Mueck B, Potter SL, Jarai G | title = cDNA representational difference analysis of human neutrophils stimulated by GM-CSF | journal = Biochemical and Biophysical Research Communications | volume = 277 | issue = 2 | pages = 401–9 | date = October 2000 | pmid = 11032736 | doi = 10.1006/bbrc.2000.3678 }} | |||
* {{cite journal | vauthors = Fauré J, Dagher MC | title = Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI) | journal = Biochimie | volume = 83 | issue = 5 | pages = 409–14 | date = May 2001 | pmid = 11368848 | doi = 10.1016/S0300-9084(01)01263-9 }} | |||
* {{cite journal | vauthors = Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B | title = The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function | journal = Molecular and Cellular Biology | volume = 22 | issue = 4 | pages = 1158–71 | date = February 2002 | pmid = 11809807 | pmc = 134637 | doi = 10.1128/MCB.22.4.1158-1171.2002 }} | |||
* {{cite journal | vauthors = Lahousse S, Smorowski AL, Denis C, Lantoine D, Kerckaert JP, Galiègue-Zouitina S | title = Structural features of hematopoiesis-specific RhoH/ARHH gene: high diversity of 5'-UTR in different hematopoietic lineages suggests a complex post-transcriptional regulation | journal = Gene | volume = 343 | issue = 1 | pages = 55–68 | date = December 2004 | pmid = 15563831 | doi = 10.1016/j.gene.2004.08.022 }} | |||
* {{cite journal | vauthors = Lopez-Ilasaca MA, Bernabe-Ortiz JC, Na SY, Dzau VJ, Xavier RJ | title = Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells | journal = FEBS Letters | volume = 579 | issue = 3 | pages = 648–54 | date = January 2005 | pmid = 15670823 | doi = 10.1016/j.febslet.2004.12.039 }} | |||
* {{cite journal | vauthors = Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL | title = High-throughput mapping of a dynamic signaling network in mammalian cells | journal = Science | volume = 307 | issue = 5715 | pages = 1621–5 | date = March 2005 | pmid = 15761153 | doi = 10.1126/science.1105776 }} | |||
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }} | |||
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = January 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }} | |||
* {{cite journal | vauthors = Reiniger L, Bödör C, Bognár A, Balogh Z, Csomor J, Szepesi A, Kopper L, Matolcsy A | title = Richter's and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutation | journal = Leukemia | volume = 20 | issue = 6 | pages = 1089–95 | date = June 2006 | pmid = 16541139 | doi = 10.1038/sj.leu.2404183 }} | |||
* {{cite journal | vauthors = Hiraga J, Katsumi A, Iwasaki T, Abe A, Kiyoi H, Matsushita T, Kinoshita T, Naoe T | title = Prognostic analysis of aberrant somatic hypermutation of RhoH gene in diffuse large B cell lymphoma | journal = Leukemia | volume = 21 | issue = 8 | pages = 1846–7 | date = August 2007 | pmid = 17443219 | doi = 10.1038/sj.leu.2404717 }} | |||
* {{cite journal | vauthors = Traverse-Glehen A, Verney A, Baseggio L, Felman P, Callet-Bauchu E, Thieblemont C, Ffrench M, Magaud JP, Coiffier B, Berger F, Salles G | title = Analysis of BCL-6, CD95, PIM1, RHO/TTF and PAX5 mutations in splenic and nodal marginal zone B-cell lymphomas suggests a particular B-cell origin | journal = Leukemia | volume = 21 | issue = 8 | pages = 1821–4 | date = August 2007 | pmid = 17476282 | doi = 10.1038/sj.leu.2404706 }} | |||
{{Refend}} | |||
{{Rho family of GTPases}} | {{Rho family of GTPases}} | ||
{{Gene-4-stub}} |
Latest revision as of 16:17, 8 October 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
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UniProt |
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RefSeq (mRNA) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
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RhoH (Ras homolog gene family, member H) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.[1] It is encoded by the gene RHOH.[2]
Gene
Expression of a chimeric transcript of LAZ3 and this gene has been reported as a result of the translocation t(3;4) in non-Hodgkin's lymphomas. Unlike most other small G proteins which are expressed ubiquitously, this gene is transcribed only in hemopoietic cells.[2]
Interactions
RhoH has been shown to interact with ARHGDIA.[3][4]
References
- ↑ Ridley AJ (October 2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends in Cell Biology. 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. PMID 16949823.
- ↑ 2.0 2.1 "Entrez Gene: RHOH ras homolog gene family, member H".
- ↑ Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B (February 2002). "The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function". Molecular and Cellular Biology. 22 (4): 1158–71. doi:10.1128/MCB.22.4.1158-1171.2002. PMC 134637. PMID 11809807.
- ↑ Fauré J, Dagher MC (May 2001). "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)". Biochimie. 83 (5): 409–14. doi:10.1016/S0300-9084(01)01263-9. PMID 11368848.
Further reading
- Dallery E, Galiègue-Zouitina S, Collyn-d'Hooghe M, Quief S, Denis C, Hildebrand MP, Lantoine D, Deweindt C, Tilly H, Bastard C (June 1995). "TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation". Oncogene. 10 (11): 2171–8. PMID 7784061.
- Dallery-Prudhomme E, Roumier C, Denis C, Preudhomme C, Kerckaert JP, Galiegue-Zouitina S (July 1997). "Genomic structure and assignment of the RhoH/TTF small GTPase gene (ARHH) to 4p13 by in situ hybridization". Genomics. 43 (1): 89–94. doi:10.1006/geno.1997.4788. PMID 9226377.
- Yousefi S, Cooper PR, Mueck B, Potter SL, Jarai G (October 2000). "cDNA representational difference analysis of human neutrophils stimulated by GM-CSF". Biochemical and Biophysical Research Communications. 277 (2): 401–9. doi:10.1006/bbrc.2000.3678. PMID 11032736.
- Fauré J, Dagher MC (May 2001). "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)". Biochimie. 83 (5): 409–14. doi:10.1016/S0300-9084(01)01263-9. PMID 11368848.
- Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B (February 2002). "The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function". Molecular and Cellular Biology. 22 (4): 1158–71. doi:10.1128/MCB.22.4.1158-1171.2002. PMC 134637. PMID 11809807.
- Lahousse S, Smorowski AL, Denis C, Lantoine D, Kerckaert JP, Galiègue-Zouitina S (December 2004). "Structural features of hematopoiesis-specific RhoH/ARHH gene: high diversity of 5'-UTR in different hematopoietic lineages suggests a complex post-transcriptional regulation". Gene. 343 (1): 55–68. doi:10.1016/j.gene.2004.08.022. PMID 15563831.
- Lopez-Ilasaca MA, Bernabe-Ortiz JC, Na SY, Dzau VJ, Xavier RJ (January 2005). "Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells". FEBS Letters. 579 (3): 648–54. doi:10.1016/j.febslet.2004.12.039. PMID 15670823.
- Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (March 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Reiniger L, Bödör C, Bognár A, Balogh Z, Csomor J, Szepesi A, Kopper L, Matolcsy A (June 2006). "Richter's and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutation". Leukemia. 20 (6): 1089–95. doi:10.1038/sj.leu.2404183. PMID 16541139.
- Hiraga J, Katsumi A, Iwasaki T, Abe A, Kiyoi H, Matsushita T, Kinoshita T, Naoe T (August 2007). "Prognostic analysis of aberrant somatic hypermutation of RhoH gene in diffuse large B cell lymphoma". Leukemia. 21 (8): 1846–7. doi:10.1038/sj.leu.2404717. PMID 17443219.
- Traverse-Glehen A, Verney A, Baseggio L, Felman P, Callet-Bauchu E, Thieblemont C, Ffrench M, Magaud JP, Coiffier B, Berger F, Salles G (August 2007). "Analysis of BCL-6, CD95, PIM1, RHO/TTF and PAX5 mutations in splenic and nodal marginal zone B-cell lymphomas suggests a particular B-cell origin". Leukemia. 21 (8): 1821–4. doi:10.1038/sj.leu.2404706. PMID 17476282.
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