CHRNB4: Difference between revisions

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{{Infobox_gene}}
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'''Neuronal acetylcholine receptor subunit beta-4''' is a [[protein]] that in humans is encoded by the ''CHRNB4'' [[gene]].<ref name="pmid2004777">{{cite journal | vauthors = Eng CM, Kozak CA, Beaudet AL, Zoghbi HY|authorlink4=Huda Zoghbi | title = Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse | journal = Genomics | volume = 9 | issue = 2 | pages = 278–282 |date=Apr 1991 | pmid = 2004777 | pmc =  | doi =10.1016/0888-7543(91)90253-B }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CHRNB4 cholinergic receptor, nicotinic, beta 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1143| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Cholinergic receptor, nicotinic, beta 4
| HGNCid = 1964
| Symbol = CHRNB4
| AltSymbols =;
| OMIM = 118509
| ECnumber = 
| Homologene = 20196
| MGIid = 87892
| GeneAtlas_image1 = PBB_GE_CHRNB4_207516_at_tn.png
| Function = {{GNF_GO|id=GO:0004889 |text = nicotinic acetylcholine-activated cation-selective channel activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005230 |text = extracellular ligand-gated ion channel activity}} {{GNF_GO|id=GO:0015267 |text = channel activity}} {{GNF_GO|id=GO:0015464 |text = acetylcholine receptor activity}}
  | Component = {{GNF_GO|id=GO:0005892 |text = nicotinic acetylcholine-gated receptor-channel complex}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
  | Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007271 |text = synaptic transmission, cholinergic}} {{GNF_GO|id=GO:0046928 |text = regulation of neurotransmitter secretion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1143
    | Hs_Ensembl = ENSG00000117971
    | Hs_RefseqProtein = NP_000741
    | Hs_RefseqmRNA = NM_000750
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 76703691
    | Hs_GenLoc_end = 76720646
    | Hs_Uniprot = P30926
    | Mm_EntrezGene = 108015
    | Mm_Ensembl = ENSMUSG00000035200
    | Mm_RefseqmRNA = NM_148944
    | Mm_RefseqProtein = NP_683746
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 54826293
    | Mm_GenLoc_end = 54846727
    | Mm_Uniprot = Q3TUU6
  }}
}}
'''Cholinergic receptor, nicotinic, beta 4''', also known as '''CHRNB4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CHRNB4 cholinergic receptor, nicotinic, beta 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1143| accessdate = }}</ref>


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| summary_text =  
}}
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== Interactive pathway map ==
{{NicotineChromaffinActivity_WP1603|highlight=CHRNB4}}


==See also==
==See also==
Line 58: Line 15:


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin |30em}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Green WN, Millar NS |title=Ion-channel assembly. |journal=Trends Neurosci. |volume=18 |issue= 6 |pages= 280-7 |year= 1995 |pmid= 7571003 |doi=  }}
*{{cite journal  | vauthors=Green WN, Millar NS |title=Ion-channel assembly |journal=Trends Neurosci. |volume=18 |issue= 6 |pages= 280–287 |year= 1995 |pmid= 7571003 |doi=10.1016/0166-2236(95)93915-K }}
*{{cite journal  | author=Hogg RC, Raggenbass M, Bertrand D |title=Nicotinic acetylcholine receptors: from structure to brain function. |journal=Rev. Physiol. Biochem. Pharmacol. |volume=147 |issue=  |pages= 1-46 |year= 2003 |pmid= 12783266 |doi= 10.1007/s10254-003-0005-1 }}
*{{cite journal  | vauthors=Hogg RC, Raggenbass M, Bertrand D |title=Nicotinic acetylcholine receptors: from structure to brain function |journal=Rev. Physiol. Biochem. Pharmacol. |volume=147 |issue=  |pages= 1–46 |year= 2003 |pmid= 12783266 |doi= 10.1007/s10254-003-0005-1  | series=Reviews of Physiology, Biochemistry and Pharmacology  | isbn=978-3-540-01365-5 }}
*{{cite journal | author=Tarroni P, Rubboli F, Chini B, ''et al.'' |title=Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines. |journal=FEBS Lett. |volume=312 |issue= 1 |pages= 66-70 |year= 1992 |pmid= 1330682 |doi= }}
*{{cite journal | author=Tarroni P |title=Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines |journal=FEBS Lett. |volume=312 |issue= 1 |pages= 66–70 |year= 1992 |pmid= 1330682 |doi=10.1016/0014-5793(92)81411-E  |name-list-format=vanc| author2=Rubboli F  | author3=Chini B  | display-authors=3  | last4=Zwart  | first4=R  | last5=Oortgiesen  | first5=M | last6=Sher  | first6=E  | last7=Clementi  | first7=F  }}
*{{cite journal  | author=Anand R, Lindstrom J |title=Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans. |journal=Genomics |volume=13 |issue= 4 |pages= 962-7 |year= 1992 |pmid= 1505988 |doi=  }}
*{{cite journal  | vauthors=Anand R, Lindstrom J |title=Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans |journal=Genomics |volume=13 |issue= 4 |pages= 962–967 |year= 1992 |pmid= 1505988 |doi=10.1016/0888-7543(92)90008-G }}
*{{cite journal  | author=Raimondi E, Rubboli F, Moralli D, ''et al.'' |title=Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits. |journal=Genomics |volume=12 |issue= 4 |pages= 849-50 |year= 1992 |pmid= 1572664 |doi=  }}
*{{cite journal  | author=Raimondi E |title=Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits |journal=Genomics |volume=12 |issue= 4 |pages= 849–50 |year= 1992 |pmid= 1572664 |doi=  10.1016/0888-7543(92)90324-L|name-list-format=vanc| author2=Rubboli F  | author3=Moralli D  | display-authors=3 | last4=Chini  | first4=B  | last5=Fornasari | first5=D  | last6=Tarroni  | first6=P  | last7=De Carli  | first7=L  | last8=Clementi  | first8=F }}
*{{cite journal  | author=Boulter J, O'Shea-Greenfield A, Duvoisin RM, ''et al.'' |title=Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster. |journal=J. Biol. Chem. |volume=265 |issue= 8 |pages= 4472-82 |year= 1990 |pmid= 1689727 |doi=  }}
*{{cite journal  | author=Boulter J |title=Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster |journal=J. Biol. Chem. |volume=265 |issue= 8 |pages= 4472–82 |year= 1990 |pmid= 1689727 |doi=  |name-list-format=vanc| author2=O'Shea-Greenfield A  | author3=Duvoisin RM  | display-authors=3 | last4=Connolly  | first4=JG  | last5=Wada  | first5=E  | last6=Jensen  | first6=A  | last7=Gardner  | first7=PD  | last8=Ballivet  | first8=M  | last9=Deneris  | first9=ES }}
*{{cite journal  | author=Papke RL, Heinemann SF |title=The role of the beta 4-subunit in determining the kinetic properties of rat neuronal nicotinic acetylcholine alpha 3-receptors. |journal=J. Physiol. (Lond.) |volume=440 |issue=  |pages= 95-112 |year= 1992 |pmid= 1725184 |doi=  }}
*{{cite journal  | vauthors=Papke RL, Heinemann SF |title=The role of the beta 4-subunit in determining the kinetic properties of rat neuronal nicotinic acetylcholine alpha 3-receptors |journal=J. Physiol. |volume=440 |issue= |pages= 95–112 |year= 1992 |pmid= 1725184 |doi= 10.1113/jphysiol.1991.sp018698| pmc=1180142 }}
*{{cite journal  | author=Eng CM, Kozak CA, Beaudet AL, Zoghbi HY |title=Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse. |journal=Genomics |volume=9 |issue= 2 |pages= 278-82 |year= 1991 |pmid= 2004777 |doi=  }}
*{{cite journal  | author=Elliott KJ |title=Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits |journal=J. Mol. Neurosci. |volume=7 |issue= 3 |pages= 217–228 |year= 1997 |pmid= 8906617 |doi=10.1007/BF02736842 |name-list-format=vanc| author2=Ellis SB | author3=Berckhan KJ  | display-authors=3  | last4=Urrutia  | first4=Arturo  | last5=Chavez-Noriega  | first5=Laura E. | last6=Johnson  | first6=Edwin C. | last7=Veliçelebi  | first7=Gönül  | last8=Harpold  | first8=Michael M.  }}
*{{cite journal  | author=Elliott KJ, Ellis SB, Berckhan KJ, ''et al.'' |title=Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits. |journal=J. Mol. Neurosci. |volume=7 |issue= 3 |pages= 217-28 |year= 1997 |pmid= 8906617 |doi=  }}
*{{cite journal  | author=Chavez-Noriega LE |title=Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes |journal=J. Pharmacol. Exp. Ther. |volume=280 |issue= 1 |pages= 346–56 |year= 1997 |pmid= 8996215 |doi= |name-list-format=vanc| author2=Crona JH  | author3=Washburn MS  | display-authors=3  | last4=Urrutia  | first4=A  | last5=Elliott  | first5=KJ  | last6=Johnson  | first6=EC }}
*{{cite journal  | author=Chavez-Noriega LE, Crona JH, Washburn MS, ''et al.'' |title=Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes. |journal=J. Pharmacol. Exp. Ther. |volume=280 |issue= 1 |pages= 346-56 |year= 1997 |pmid= 8996215 |doi=  }}
*{{cite journal  | vauthors=Groot Kormelink PJ, Luyten WH |title=Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32 |journal=FEBS Lett. |volume=400 |issue= 3 |pages= 309–314 |year= 1997 |pmid= 9009220 |doi=10.1016/S0014-5793(96)01383-X  }}
*{{cite journal  | author=Groot Kormelink PJ, Luyten WH |title=Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32. |journal=FEBS Lett. |volume=400 |issue= 3 |pages= 309-14 |year= 1997 |pmid= 9009220 |doi=  }}
*{{cite journal  | vauthors=Navaneetham D, Penn A, Howard J, Conti-Fine BM |title=Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=43 |issue= 3 |pages= 433–42 |year= 1997 |pmid= 9193799 |doi=  }}
*{{cite journal | author=Navaneetham D, Penn A, Howard J, Conti-Fine BM |title=Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=43 |issue= 3 |pages= 433-42 |year= 1997 |pmid= 9193799 |doi=  }}
*{{cite journal  | vauthors=Gerzanich V, Kuryatov A, Anand R, Lindstrom J |title="Orphan" alpha6 nicotinic AChR subunit can form a functional heteromeric acetylcholine receptor |journal=Mol. Pharmacol. |volume=51 |issue= 2 |pages= 320–7 |year= 1997 |pmid= 9203638 |doi=  }}
*{{cite journal  | author=Gerzanich V, Kuryatov A, Anand R, Lindstrom J |title="Orphan" alpha6 nicotinic AChR subunit can form a functional heteromeric acetylcholine receptor. |journal=Mol. Pharmacol. |volume=51 |issue= 2 |pages= 320-7 |year= 1997 |pmid= 9203638 |doi= }}
*{{cite journal  | vauthors=Gerzanich V, Wang F, Kuryatov A, Lindstrom J |title=alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors |journal=J. Pharmacol. Exp. Ther. |volume=286 |issue= 1 |pages= 311–20 |year= 1998 |pmid= 9655874 |doi=  }}
*{{cite journal  | author=Gerzanich V, Wang F, Kuryatov A, Lindstrom J |title=alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors. |journal=J. Pharmacol. Exp. Ther. |volume=286 |issue= 1 |pages= 311-20 |year= 1998 |pmid= 9655874 |doi=  }}
*{{cite journal  | author=Hellström-Lindahl E |title=Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord |journal=Brain Res. Dev. Brain Res. |volume=108 |issue= 1–2 |pages= 147–160 |year= 1998 |pmid= 9693793 |doi=10.1016/S0165-3806(98)00046-7  |name-list-format=vanc| author2=Gorbounova O  | author3=Seiger A  | display-authors=3  | last4=Mousavi  | first4=M  | last5=Nordberg  | first5=A  }}
*{{cite journal  | author=Hellström-Lindahl E, Gorbounova O, Seiger A, ''et al.'' |title=Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord. |journal=Brain Res. Dev. Brain Res. |volume=108 |issue= 1-2 |pages= 147-60 |year= 1998 |pmid= 9693793 |doi= }}
*{{cite journal  | author=Sato KZ |title=Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines |journal=Neurosci. Lett. |volume=266 |issue= 1 |pages= 17–20 |year= 1999 |pmid= 10336173 |doi=10.1016/S0304-3940(99)00259-1  |name-list-format=vanc| author2=Fujii T  | author3=Watanabe Y  | display-authors=3  | last4=Yamada  | first4=Shin  | last5=Ando  | first5=Tsuyoshi  | last6=Kazuko  | first6=Fujimoto  | last7=Kawashima  | first7=Koichiro  }}
*{{cite journal  | author=Sato KZ, Fujii T, Watanabe Y, ''et al.'' |title=Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines. |journal=Neurosci. Lett. |volume=266 |issue= 1 |pages= 17-20 |year= 1999 |pmid= 10336173 |doi=  }}
*{{cite journal  | vauthors=Boorman JP, Groot-Kormelink PJ, Sivilotti LG |title=Stoichiometry of human recombinant neuronal nicotinic receptors containing the b3 subunit expressed in Xenopus oocytes |journal=J. Physiol. |volume=529 |issue=  3|pages= 565–77 |year= 2001 |pmid= 11118490 |doi=  10.1111/j.1469-7793.2000.00565.x| pmc=2270211  }}
*{{cite journal  | author=Boorman JP, Groot-Kormelink PJ, Sivilotti LG |title=Stoichiometry of human recombinant neuronal nicotinic receptors containing the b3 subunit expressed in Xenopus oocytes. |journal=J. Physiol. (Lond.) |volume=529 Pt 3 |issue= |pages= 565-77 |year= 2001 |pmid= 11118490 |doi=  }}
*{{cite journal  | author=Lev-Lehman E |title=Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4 |journal=J. Hum. Genet. |volume=46 |issue= 7 |pages= 362–366 |year= 2001 |pmid= 11450844 |doi=10.1007/PL00010921  |name-list-format=vanc| author2=Bercovich D  | author3=Xu W  | display-authors=3  | last4=Stockton  | first4=D. W.  | last5=Beaudet  | first5=A. L.  }}
*{{cite journal  | author=Lev-Lehman E, Bercovich D, Xu W, ''et al.'' |title=Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4. |journal=J. Hum. Genet. |volume=46 |issue= 7 |pages= 362-6 |year= 2001 |pmid= 11450844 |doi=  }}
*{{cite journal  | vauthors=Groot-Kormelink PJ, Boorman JP, Sivilotti LG |title=Formation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach |journal=Br. J. Pharmacol. |volume=134 |issue= 4 |pages= 789–796 |year= 2001 |pmid= 11606319 |doi= 10.1038/sj.bjp.0704313  | pmc=1573006 }}
*{{cite journal  | author=Groot-Kormelink PJ, Boorman JP, Sivilotti LG |title=Formation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach. |journal=Br. J. Pharmacol. |volume=134 |issue= 4 |pages= 789-96 |year= 2001 |pmid= 11606319 |doi= 10.1038/sj.bjp.0704313 }}
}}
}}
{{refend}}
{{refend}}
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== External links ==
== External links ==
* {{MeshName|CHRNB4+protein,+human}}
* {{MeshName|CHRNB4+protein,+human}}
* {{UCSC gene info|CHRNB4}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ligand-gated ion channels}}
{{Ligand-gated ion channels}}
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[[Category:Ion channels]]
[[Category:Ion channels]]
{{WikiDoc Sources}}
[[Category:Nicotinic acetylcholine receptors]]
 
 
{{membrane-protein-stub}}

Latest revision as of 16:02, 8 October 2017

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Wikidata
View/Edit Human

Neuronal acetylcholine receptor subunit beta-4 is a protein that in humans is encoded by the CHRNB4 gene.[1][2]


Interactive pathway map

Click on genes, proteins and metabolites below to link to respective Wikipedia articles. [§ 1]

[[File:
<imagemap> Image:NicotineChromaffinCells_WP1603.png
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<imagemap> Image:NicotineChromaffinCells_WP1603.png
|{{{bSize}}}px|alt=Nicotine Activity on Chromaffin Cells edit]]
Nicotine Activity on Chromaffin Cells edit
  1. ↑ The interactive pathway map can be edited at WikiPathways: "NicotineActivityonChromaffinCells_WP1603".

See also

References

  1. ↑ Eng CM, Kozak CA, Beaudet AL, Zoghbi HY (Apr 1991). "Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse". Genomics. 9 (2): 278–282. doi:10.1016/0888-7543(91)90253-B. PMID 2004777.
  2. ↑ "Entrez Gene: CHRNB4 cholinergic receptor, nicotinic, beta 4".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Retrieved from "https://www.wikidoc.org/index.php?title=CHRNB4&oldid=1416838"