G12/G13 alpha subunits: Difference between revisions

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{{protein
{{DISPLAYTITLE:G<sub>12</sub>/G<sub>13</sub> alpha subunits}}
|Name= [[GNA12|guanine nucleotide binding protein (G protein) alpha 12]]
{{infobox protein
|Name= [[GNA12|guanine nucleotide-binding protein (G protein) alpha 12]]
|caption=
|caption=
|image=
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|LocusSupplementaryData=
|LocusSupplementaryData=
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}}
{{protein
{{infobox protein
|Name=guanine nucleotide binding protein (G protein), alpha 13
|Name=guanine nucleotide-binding protein (G protein), alpha 13
|caption=
|caption=
|image=
|image=
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|LocusSupplementaryData=
|LocusSupplementaryData=
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'''G<sub>12</sub>/G<sub>13</sub>''' subunits are alpha units of [[heterotrimeric G protein]]s that regulate cell processes through the use of [[guanine nucleotide exchange factor]]s.<ref name="pmid8842523">{{cite journal |vauthors=Dhanasekaran N, Dermott JM | title = Signaling by the G12 class of G proteins | journal = Cell. Signal. | volume = 8 | issue = 4 | pages = 235–45 | year = 1996 | pmid = 8842523 | doi = 10.1016/0898-6568(96)00048-4 }}</ref>  These two subunits represent a fourth class of G protein alpha subunits.<ref name="pmid1905812">{{cite journal |vauthors=Strathmann MP, Simon MI | title = G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 88 | issue = 13 | pages = 5582–6 | year = 1991 | pmid = 1905812 | doi = 10.1073/pnas.88.13.5582 | pmc = 51921 }}</ref> They are not sensitive to [[pertussis toxin]].<ref name="pmid8870664">{{cite journal |vauthors=Harhammer R, Nürnberg B, Harteneck C, Leopoldt D, Exner T, Schultz G | title = Distinct biochemical properties of the native members of the G<sub>12</sub> G-protein subfamily. Characterization of G alpha 12 purified from rat brain | journal = Biochem. J. | volume = ( Pt 1) | issue = | pages = 165–71 | series = 319 | year = 1996 | pmid = 8870664 | doi = | issn = | url = http://www.biochemj.org/bj/319/bj3190165.htm | pmc = 1217750 }}</ref>


 
G proteins G<sub>12</sub> and G<sub>13</sub> regulate [[actin]] [[cytoskeleton|cytoskeletal]] remodeling in cells.<ref name="pmid16943201">{{cite journal |vauthors=Wang D, Tan YC, Kreitzer GE, Nakai Y, Shan D, Zheng Y, Huang XY | title = G proteins G12 and G13 control the dynamic turnover of growth factor-induced dorsal ruffles | journal = J. Biol. Chem. | volume = 281 | issue = 43 | pages = 32660–7 | year = 2006 | pmid = 16943201 | doi = 10.1074/jbc.M604588200 }}</ref> G<sub>13</sub> is also essential for [[receptor tyrosine kinase]]-induced [[cell migration|migration]] of [[fibroblast]] and [[endothelial]] cells.<ref name="pmid16740474">{{cite journal |vauthors=Shan D, Chen L, Wang D, Tan YC, Gu JL, Huang XY | title = The G protein G alpha(13) is required for growth factor-induced cell migration | journal = Dev. Cell | volume = 10 | issue = 6 | pages = 707–18 | year = 2006 | pmid = 16740474 | doi = 10.1016/j.devcel.2006.03.014 }}</ref>
==Overview==
'''G12/G13''' subunits are alpha units of [[heterotrimeric G protein]]s which regulate cell process through the use of [[guanine nucleotide exchange factor]]s.<ref name="pmid8842523">{{cite journal | author = Dhanasekaran N, Dermott JM | title = Signaling by the G12 class of G proteins | journal = Cell. Signal. | volume = 8 | issue = 4 | pages = 235–45 | year = 1996 | pmid = 8842523 | doi = 10.1016/0898-6568(96)00048-4 | issn = }}</ref>  These two subunits represent a fourth class of G protein alpha subunits.<ref name="pmid1905812">{{cite journal | author = Strathmann MP, Simon MI | title = G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 88 | issue = 13 | pages = 5582–6 | year = 1991 | pmid = 1905812 | doi = 10.1073/pnas.88.13.5582 | issn = }}</ref> They are not sensitive to [[pertussis toxin]].<ref name="pmid8870664">{{cite journal | author = Harhammer R, Nürnberg B, Harteneck C, Leopoldt D, Exner T, Schultz G | title = Distinct biochemical properties of the native members of the G12 G-protein subfamily. Characterization of G alpha 12 purified from rat brain | journal = Biochem. J. | volume = 319 ( Pt 1) | issue = | pages = 165–71 | year = 1996 | pmid = 8870664 | doi = | issn = | url = http://www.biochemj.org/bj/319/bj3190165.htm }}</ref>
 
G proteins G12 and G13 regulate [[actin]] [[cytoskeleton|cytoskeletal]] remodeling in cells.<ref name="pmid16943201">{{cite journal | author = Wang D, Tan YC, Kreitzer GE, Nakai Y, Shan D, Zheng Y, Huang XY | title = G proteins G12 and G13 control the dynamic turnover of growth factor-induced dorsal ruffles | journal = J. Biol. Chem. | volume = 281 | issue = 43 | pages = 32660–7 | year = 2006 | pmid = 16943201 | doi = 10.1074/jbc.M604588200 | issn = }}</ref> G13 is also essential for [[receptor tyrosine kinase]]-induced [[cell migration|migration]] of [[fibroblast]] and [[endothelial]] cells.<ref name="pmid16740474">{{cite journal | author = Shan D, Chen L, Wang D, Tan YC, Gu JL, Huang XY | title = The G protein G alpha(13) is required for growth factor-induced cell migration | journal = Dev. Cell | volume = 10 | issue = 6 | pages = 707–18 | year = 2006 | pmid = 16740474 | doi = 10.1016/j.devcel.2006.03.014 | issn = }}</ref>


==Genes==
==Genes==
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* {{MeshName|GTP-Binding+Protein+alpha+Subunits,+G12-G13}}
* {{MeshName|GTP-Binding+Protein+alpha+Subunits,+G12-G13}}


{{GTPases}}
{{Acid anhydride hydrolases}}
{{Enzymes}}
{{Portal bar|Molecular and Cellular Biology|border=no}}
 
{{DEFAULTSORT:G12 G13 alpha subunits}}
[[Category:G proteins|*]]
[[Category:G proteins|*]]
[[Category:Membrane biology]]
[[Category:Membrane biology]]
[[Category:Peripheral membrane proteins]]
[[Category:Peripheral membrane proteins]]
{{WH}}
{{WS}}

Latest revision as of 09:14, 25 May 2016

guanine nucleotide-binding protein (G protein) alpha 12
Identifiers
SymbolGNA12
Entrez2768
HUGO4380
OMIM604394
RefSeqNM_007353
UniProtQ03113
Other data
LocusChr. 7 p22.3
guanine nucleotide-binding protein (G protein), alpha 13
Identifiers
SymbolGNA13
Entrez10672
HUGO4381
OMIM604406
RefSeqNM_006572
UniProtQ14344
Other data
LocusChr. 17 q24

G12/G13 subunits are alpha units of heterotrimeric G proteins that regulate cell processes through the use of guanine nucleotide exchange factors.[1] These two subunits represent a fourth class of G protein alpha subunits.[2] They are not sensitive to pertussis toxin.[3]

G proteins G12 and G13 regulate actin cytoskeletal remodeling in cells.[4] G13 is also essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells.[5]

Genes

References

  1. ↑ Dhanasekaran N, Dermott JM (1996). "Signaling by the G12 class of G proteins". Cell. Signal. 8 (4): 235–45. doi:10.1016/0898-6568(96)00048-4. PMID 8842523.
  2. ↑ Strathmann MP, Simon MI (1991). "G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits". Proc. Natl. Acad. Sci. U.S.A. 88 (13): 5582–6. doi:10.1073/pnas.88.13.5582. PMC 51921. PMID 1905812.
  3. ↑ Harhammer R, Nürnberg B, Harteneck C, Leopoldt D, Exner T, Schultz G (1996). "Distinct biochemical properties of the native members of the G12 G-protein subfamily. Characterization of G alpha 12 purified from rat brain". Biochem. J. 319. ( Pt 1): 165–71. PMC 1217750. PMID 8870664.
  4. ↑ Wang D, Tan YC, Kreitzer GE, Nakai Y, Shan D, Zheng Y, Huang XY (2006). "G proteins G12 and G13 control the dynamic turnover of growth factor-induced dorsal ruffles". J. Biol. Chem. 281 (43): 32660–7. doi:10.1074/jbc.M604588200. PMID 16943201.
  5. ↑ Shan D, Chen L, Wang D, Tan YC, Gu JL, Huang XY (2006). "The G protein G alpha(13) is required for growth factor-induced cell migration". Dev. Cell. 10 (6): 707–18. doi:10.1016/j.devcel.2006.03.014. PMID 16740474.

External links

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