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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Mediator of RNA polymerase II transcription subunit 1''' also known as '''DRIP205''' or '''Trap220''' is a subunit of the [[Mediator complex]] and is a [[protein]] that in humans is encoded by the ''MED1'' [[gene]].<ref name="pmid9325263">{{cite journal | vauthors = Zhu Y, Qi C, Jain S, Rao MS, Reddy JK | title = Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor | journal = J Biol Chem | volume = 272 | issue = 41 | pages = 25500–6 | date = November 1997 | pmid = 9325263 | pmc =  | doi = 10.1074/jbc.272.41.25500 }}</ref><ref name="pmid10485914">{{cite journal | vauthors = Zhu Y, Qi C, Jain S, Le Beau MM, Espinosa R, Atkins GB, Lazar MA, Yeldandi AV, Rao MS, Reddy JK | title = Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer | journal = Proc Natl Acad Sci U S A | volume = 96 | issue = 19 | pages = 10848–53 | date = October 1999 | pmid = 10485914 | pmc = 17971 | doi = 10.1073/pnas.96.19.10848 }}</ref><ref name="entrez">{{Cite web| title = Entrez Gene: PPARBP PPAR binding protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5469| accessdate = }}</ref> MED1 functions as a [[nuclear receptor]] [[coactivator (genetics)|coactivator]].
| update_page = yes
{{Infobox protein family
| require_manual_inspection = no
| Symbol = Med1
| update_protein_box = yes
| Name = Med1
| update_summary = yes
| image =
| update_citations = yes
| width =
| caption =
| Pfam = PF10744
| Pfam_clan = 
| InterPro = IPR019680
| SMART =
| PROSITE =
| MEROPS =
| SCOP =
| TCDB =  
| OPM family =  
| OPM protein =  
| CAZy =  
| CDD =  
}}
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
 
| image =
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in [[DNA]]. These factors work with co-activators to direct transcriptional initiation by the [[RNA polymerase II]] apparatus. The mediator of RNA polymerase II transcription subunit 1 protein is a subunit of the CRSP (cofactor required for [[Sp1 transcription factor|SP1]] activation) complex, which, along with [[Transcription factor II D|TFIID]], is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes [e.g., [[thyroid hormone receptor]]-(TR-) associated proteins that interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors]. It also regulates [[p53]]-dependent [[apoptosis]] and it is essential for [[adipogenesis]]. This protein is known to have the ability to self-oligomerize.<ref name="entrez"/>
| image_source =
 
| PDB =  
== Interactions ==
| Name = Mediator complex subunit 1
 
| HGNCid = 9234
MED1 has been shown to [[Protein-protein interaction|interact]] with:
| Symbol = MED1
{{div col|colwidth=20em}}
| AltSymbols =; PPARBP; PBP; CRSP1; CRSP200; DRIP205; DRIP230; MGC71488; PPARGBP; RB18A; TRAP220; TRIP2
* [[Androgen receptor]],<ref name = pmid12218053>{{cite journal | vauthors = Wang Q, Sharma D, Ren Y, Fondell JD | title = A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression | journal = J. Biol. Chem. | volume = 277 | issue = 45 | pages = 42852–8 | date = November 2002 | pmid = 12218053 | doi = 10.1074/jbc.M206061200 }}</ref>
| OMIM = 604311
* [[BRCA1]],<ref name = pmid15208681>{{cite journal | vauthors = Wada O, Oishi H, Takada I, Yanagisawa J, Yano T, Kato S | title = BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220 | journal = Oncogene | volume = 23 | issue = 35 | pages = 6000–5 | date = August 2004 | pmid = 15208681 | doi = 10.1038/sj.onc.1207786 }}</ref>
| ECnumber =
* [[Calcitriol receptor]],<ref name = pmid10198638/><ref name = pmid12837248/>
| Homologene = 21002
* [[Cyclin-dependent kinase 8]],<ref name = pmid10198638>{{cite journal | vauthors = Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG | title = Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators | journal = Mol. Cell | volume = 3 | issue = 3 | pages = 361–70 | date = March 1999 | pmid = 10198638 | doi = 10.1016/s1097-2765(00)80463-3 }}</ref><ref name = pmid11867769>{{cite journal | vauthors = Kang YK, Guermah M, Yuan CX, Roeder RG | title = The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 5 | pages = 2642–7 | date = March 2002 | pmid = 11867769 | pmc = 122401 | doi = 10.1073/pnas.261715899 }}</ref>
| MGIid = 1100846
* [[Estrogen receptor alpha]],<ref name = pmid12837248>{{cite journal | vauthors = Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S | title = The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome | journal = Cell | volume = 113 | issue = 7 | pages = 905–17 | date = June 2003 | pmid = 12837248 | doi = 10.1016/s0092-8674(03)00436-7 }}</ref><ref name = pmid11867769/>
| GeneAtlas_image1 = PBB_GE_PPARBP_203497_at_tn.png
* [[Glucocorticoid receptor]],<ref name = pmid11266503>{{cite journal | vauthors = Zilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson JA | title = Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140 | journal = Mol. Endocrinol. | volume = 15 | issue = 4 | pages = 501–11 | date = April 2001 | pmid = 11266503 | doi = 10.1210/mend.15.4.0624 }}</ref><ref name = pmid10508170>{{cite journal | vauthors = Hittelman AB, Burakov D, Iñiguez-Lluhí JA, Freedman LP, Garabedian MJ | title = Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins | journal = EMBO J. | volume = 18 | issue = 19 | pages = 5380–8 | date = October 1999 | pmid = 10508170 | pmc = 1171607 | doi = 10.1093/emboj/18.19.5380 }}</ref>
| GeneAtlas_image2 = PBB_GE_PPARBP_203496_s_at_tn.png
* [[Hepatocyte nuclear factor 4 alpha]],<ref name = pmid12089346>{{cite journal | vauthors = Maeda Y, Rachez C, Hawel L, Byus CV, Freedman LP, Sladek FM | title = Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205 | journal = Mol. Endocrinol. | volume = 16 | issue = 7 | pages = 1502–10 | date = July 2002 | pmid = 12089346 | doi = 10.1210/mend.16.7.0883 }}</ref><ref name = pmid12101254>{{cite journal | vauthors = Malik S, Wallberg AE, Kang YK, Roeder RG | title = TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4 | journal = Mol. Cell. Biol. | volume = 22 | issue = 15 | pages = 5626–37 | date = August 2002 | pmid = 12101254 | pmc = 133960 | doi = 10.1128/mcb.22.15.5626-5637.2002 }}</ref>
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016455 |text = RNA polymerase II transcription mediator activity}} {{GNF_GO|id=GO:0030374 |text = ligand-dependent nuclear receptor transcription coactivator activity}} {{GNF_GO|id=GO:0031177 |text = phosphopantetheine binding}} {{GNF_GO|id=GO:0042809 |text = vitamin D receptor binding}} {{GNF_GO|id=GO:0046966 |text = thyroid hormone receptor binding}}  
* [[P53]],<ref name = pmid11118038>{{cite journal | vauthors = Frade R, Balbo M, Barel M | title = RB18A, whose gene is localized on chromosome 17q12-q21.1, regulates in vivo p53 transactivating activity | journal = Cancer Res. | volume = 60 | issue = 23 | pages = 6585–9 | date = December 2000 | pmid = 11118038 | doi = }}</ref><ref name = pmid9444950>{{cite journal | vauthors = Drané P, Barel M, Balbo M, Frade R | title = Identification of RB18A, a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53 | journal = Oncogene | volume = 15 | issue = 25 | pages = 3013–24 | date = December 1997 | pmid = 9444950 | doi = 10.1038/sj.onc.1201492 }}</ref>
| Component = {{GNF_GO|id=GO:0000119 |text = mediator complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}}  
* [[PPARGC1A]],<ref name = pmid14636573>{{cite journal | vauthors = Wallberg AE, Yamamura S, Malik S, Spiegelman BM, Roeder RG | title = Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha | journal = Mol. Cell | volume = 12 | issue = 5 | pages = 1137–49 | date = November 2003 | pmid = 14636573 | doi = 10.1016/s1097-2765(03)00391-5 }}</ref>
| Process = {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0001889 |text = liver development}} {{GNF_GO|id=GO:0001892 |text = embryonic placenta development}} {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006367 |text = transcription initiation from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006590 |text = thyroid hormone generation}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007420 |text = brain development}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0035050 |text = embryonic heart tube development}} {{GNF_GO|id=GO:0035116 |text = embryonic hindlimb morphogenesis}} {{GNF_GO|id=GO:0035162 |text = embryonic hemopoiesis}} {{GNF_GO|id=GO:0045444 |text = fat cell differentiation}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}  
* [[Peroxisome proliferator-activated receptor gamma|PPARG]],<ref name = pmid10944516>{{cite journal | vauthors = Kodera Y, Takeyama K, Murayama A, Suzawa M, Masuhiro Y, Kato S | title = Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators | journal = J. Biol. Chem. | volume = 275 | issue = 43 | pages = 33201–4 | date = October 2000 | pmid = 10944516 | doi = 10.1074/jbc.C000517200 }}</ref>
| Orthologs = {{GNF_Ortholog_box
* [[TGS1]],<ref name = pmid11912212>{{cite journal | vauthors = Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK | title = Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation | journal = J. Biol. Chem. | volume = 277 | issue = 22 | pages = 20011–9 | date = May 2002 | pmid = 11912212 | doi = 10.1074/jbc.M201739200 }}</ref>  and
    | Hs_EntrezGene = 5469
* [[Thyroid hormone receptor alpha]].<ref name = pmid9653119>{{cite journal | vauthors = Yuan CX, Ito M, Fondell JD, Fu ZY, Roeder RG | title = The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 14 | pages = 7939–44 | date = July 1998 | pmid = 9653119 | pmc = 20908 | doi = 10.1073/pnas.95.14.7939 }}</ref>
    | Hs_Ensembl = ENSG00000125686
{{Div col end}}
    | Hs_RefseqProtein = NP_004765
 
    | Hs_RefseqmRNA = NM_004774
== Protein family ==
    | Hs_GenLoc_db =
 
    | Hs_GenLoc_chr = 17
This entry represents subunit Med1 of the Mediator complex. The Med1 forms part of the Med9 submodule of the Srb/Med complex. It is one of three subunits essential for [[wikt:viability|viability]] of the whole [[organism]] via its role in environmentally-directed cell-fate decisions.<ref name="pmid12150923">{{cite journal | vauthors = Boube M, Joulia L, Cribbs DL, Bourbon HM | title = Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man | journal = Cell | volume = 110 | issue = 2 | pages = 143–51 | date = July 2002 | pmid = 12150923 | doi = 10.1016/s0092-8674(02)00830-9 }}</ref>
    | Hs_GenLoc_start = 34816380
 
    | Hs_GenLoc_end = 34861030
== References ==
    | Hs_Uniprot = Q15648
{{Reflist|35em}}
    | Mm_EntrezGene = 19014
 
    | Mm_Ensembl = ENSMUSG00000018160
== Further reading ==
    | Mm_RefseqmRNA = NM_001080118
{{Refbegin|35em}}
    | Mm_RefseqProtein = NP_001073587
* {{cite journal | vauthors = Lee JW, Choi HS, Gyuris J, Brent R, Moore DD | title = Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. | journal = Mol. Endocrinol. | volume = 9 | issue = 2 | pages = 243–54 | year = 1995 | pmid = 7776974 | doi = 10.1210/me.9.2.243 }}
    | Mm_GenLoc_db =
* {{cite journal | vauthors = Fondell JD, Ge H, Roeder RG | title = Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 16 | pages = 8329–33 | year = 1996 | pmid = 8710870 | pmc = 38670 | doi = 10.1073/pnas.93.16.8329 }}
    | Mm_GenLoc_chr = 11
* {{cite journal | vauthors = Drané P, Barel M, Balbo M, Frade R | title = Identification of RB18A, a 205 kDa new p53 regulatory protein that shares antigenic and functional properties with p53. | journal = Oncogene | volume = 15 | issue = 25 | pages = 3013–24 | year = 1998 | pmid = 9444950 | doi = 10.1038/sj.onc.1201492 }}
    | Mm_GenLoc_start = 97968244
* {{cite journal | vauthors = Yuan CX, Ito M, Fondell JD, Fu ZY, Roeder RG | title = The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 14 | pages = 7939–44 | year = 1998 | pmid = 9653119 | pmc = 20908 | doi = 10.1073/pnas.95.14.7939 }}
    | Mm_GenLoc_end = 98009350
* {{cite journal | vauthors = Ryu S, Zhou S, Ladurner AG, Tjian R | title = The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. | journal = Nature | volume = 397 | issue = 6718 | pages = 446–50 | year = 1999 | pmid = 9989412 | doi = 10.1038/17141 }}
    | Mm_Uniprot = Q925J9
* {{cite journal | vauthors = Gu W, Malik S, Ito M, Yuan CX, Fondell JD, Zhang X, Martinez E, Qin J, Roeder RG | title = A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. | journal = Mol. Cell | volume = 3 | issue = 1 | pages = 97–108 | year = 1999 | pmid = 10024883 | doi = 10.1016/S1097-2765(00)80178-1 }}
  }}
* {{cite journal | vauthors = Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG | title = Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. | journal = Mol. Cell | volume = 3 | issue = 3 | pages = 361–70 | year = 1999 | pmid = 10198638 | doi = 10.1016/S1097-2765(00)80463-3 }}
}}
* {{cite journal | vauthors = Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, Erdjument-Bromage H, Tempst P, Freedman LP | title = Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. | journal = Nature | volume = 398 | issue = 6730 | pages = 824–8 | year = 1999 | pmid = 10235266 | doi = 10.1038/19783 }}
'''Mediator complex subunit 1''', also known as '''MED1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPARBP PPAR binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5469| accessdate = }}</ref>
* {{cite journal | vauthors = Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R | title = Composite co-activator ARC mediates chromatin-directed transcriptional activation. | journal = Nature | volume = 398 | issue = 6730 | pages = 828–32 | year = 1999 | pmid = 10235267 | doi = 10.1038/19789 }}
* {{cite journal | vauthors = Atkins GB, Hu X, Guenther MG, Rachez C, Freedman LP, Lazar MA | title = Coactivators for the orphan nuclear receptor RORalpha. | journal = Mol. Endocrinol. | volume = 13 | issue = 9 | pages = 1550–7 | year = 1999 | pmid = 10478845 | doi = 10.1210/me.13.9.1550 }}
* {{cite journal | vauthors = Rachez C, Gamble M, Chang CP, Atkins GB, Lazar MA, Freedman LP | title = The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor-binding determinants but constitute functionally distinct complexes. | journal = Mol. Cell. Biol. | volume = 20 | issue = 8 | pages = 2718–26 | year = 2000 | pmid = 10733574 | pmc = 85487 | doi = 10.1128/MCB.20.8.2718-2726.2000 }}
* {{cite journal | vauthors = Frade R, Balbo M, Barel M | title = RB18A, whose gene is localized on chromosome 17q12-q21.1, regulates in vivo p53 transactivating activity. | journal = Cancer Res. | volume = 60 | issue = 23 | pages = 6585–9 | year = 2001 | pmid = 11118038 | doi = }}
* {{cite journal | vauthors = Zilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson JA | title = Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140. | journal = Mol. Endocrinol. | volume = 15 | issue = 4 | pages = 501–11 | year = 2001 | pmid = 11266503 | doi = 10.1210/mend.15.4.0624 }}
* {{cite journal | vauthors = Crawford SE, Qi C, Misra P, Stellmach V, Rao MS, Engel JD, Zhu Y, Reddy JK | title = Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. | journal = J. Biol. Chem. | volume = 277 | issue = 5 | pages = 3585–92 | year = 2002 | pmid = 11724781 | doi = 10.1074/jbc.M107995200 }}
* {{cite journal | vauthors = Frade R, Balbo M, Barel M | title = RB18A regulates p53-dependent apoptosis. | journal = Oncogene | volume = 21 | issue = 6 | pages = 861–6 | year = 2002 | pmid = 11840331 | doi = 10.1038/sj.onc.1205177 }}
* {{cite journal | vauthors = Kang YK, Guermah M, Yuan CX, Roeder RG | title = The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 5 | pages = 2642–7 | year = 2002 | pmid = 11867769 | pmc = 122401 | doi = 10.1073/pnas.261715899 }}
* {{cite journal | vauthors = Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK | title = Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation. | journal = J. Biol. Chem. | volume = 277 | issue = 22 | pages = 20011–9 | year = 2002 | pmid = 11912212 | doi = 10.1074/jbc.M201739200 }}
* {{cite journal | vauthors = Ge K, Guermah M, Yuan CX, Ito M, Wallberg AE, Spiegelman BM, Roeder RG | title = Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. | journal = Nature | volume = 417 | issue = 6888 | pages = 563–7 | year = 2002 | pmid = 12037571 | doi = 10.1038/417563a }}
{{Refend}}


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{InterPro content|IPR019680}}
{{PBB_Summary
| section_title =
| summary_text = The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize.<ref name="entrez">{{cite web | title = Entrez Gene: PPARBP PPAR binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5469| accessdate = }}</ref>
}}


==References==
{{Transcription coregulators}}
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Lee JW, Choi HS, Gyuris J, ''et al.'' |title=Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. |journal=Mol. Endocrinol. |volume=9 |issue= 2 |pages= 243-54 |year= 1995 |pmid= 7776974 |doi=  }}
*{{cite journal  | author=Fondell JD, Ge H, Roeder RG |title=Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 16 |pages= 8329-33 |year= 1996 |pmid= 8710870 |doi=  }}
*{{cite journal  | author=Zhu Y, Qi C, Jain S, ''et al.'' |title=Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. |journal=J. Biol. Chem. |volume=272 |issue= 41 |pages= 25500-6 |year= 1997 |pmid= 9325263 |doi=  }}
*{{cite journal  | author=Drané P, Barel M, Balbo M, Frade R |title=Identification of RB18A, a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53. |journal=Oncogene |volume=15 |issue= 25 |pages= 3013-24 |year= 1998 |pmid= 9444950 |doi= 10.1038/sj.onc.1201492 }}
*{{cite journal  | author=Yuan CX, Ito M, Fondell JD, ''et al.'' |title=The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 7939-44 |year= 1998 |pmid= 9653119 |doi=  }}
*{{cite journal  | author=Ryu S, Zhou S, Ladurner AG, Tjian R |title=The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. |journal=Nature |volume=397 |issue= 6718 |pages= 446-50 |year= 1999 |pmid= 9989412 |doi= 10.1038/17141 }}
*{{cite journal  | author=Gu W, Malik S, Ito M, ''et al.'' |title=A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. |journal=Mol. Cell |volume=3 |issue= 1 |pages= 97-108 |year= 1999 |pmid= 10024883 |doi=  }}
*{{cite journal  | author=Ito M, Yuan CX, Malik S, ''et al.'' |title=Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. |journal=Mol. Cell |volume=3 |issue= 3 |pages= 361-70 |year= 1999 |pmid= 10198638 |doi=  }}
*{{cite journal  | author=Rachez C, Lemon BD, Suldan Z, ''et al.'' |title=Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. |journal=Nature |volume=398 |issue= 6730 |pages= 824-8 |year= 1999 |pmid= 10235266 |doi= 10.1038/19783 }}
*{{cite journal  | author=Näär AM, Beaurang PA, Zhou S, ''et al.'' |title=Composite co-activator ARC mediates chromatin-directed transcriptional activation. |journal=Nature |volume=398 |issue= 6730 |pages= 828-32 |year= 1999 |pmid= 10235267 |doi= 10.1038/19789 }}
*{{cite journal  | author=Atkins GB, Hu X, Guenther MG, ''et al.'' |title=Coactivators for the orphan nuclear receptor RORalpha. |journal=Mol. Endocrinol. |volume=13 |issue= 9 |pages= 1550-7 |year= 1999 |pmid= 10478845 |doi=  }}
*{{cite journal  | author=Zhu Y, Qi C, Jain S, ''et al.'' |title=Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 19 |pages= 10848-53 |year= 1999 |pmid= 10485914 |doi=  }}
*{{cite journal  | author=Rachez C, Gamble M, Chang CP, ''et al.'' |title=The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes. |journal=Mol. Cell. Biol. |volume=20 |issue= 8 |pages= 2718-26 |year= 2000 |pmid= 10733574 |doi=  }}
*{{cite journal  | author=Frade R, Balbo M, Barel M |title=RB18A, whose gene is localized on chromosome 17q12-q21.1, regulates in vivo p53 transactivating activity. |journal=Cancer Res. |volume=60 |issue= 23 |pages= 6585-9 |year= 2001 |pmid= 11118038 |doi=  }}
*{{cite journal  | author=Zilliacus J, Holter E, Wakui H, ''et al.'' |title=Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140. |journal=Mol. Endocrinol. |volume=15 |issue= 4 |pages= 501-11 |year= 2001 |pmid= 11266503 |doi=  }}
*{{cite journal  | author=Crawford SE, Qi C, Misra P, ''et al.'' |title=Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3585-92 |year= 2002 |pmid= 11724781 |doi= 10.1074/jbc.M107995200 }}
*{{cite journal  | author=Frade R, Balbo M, Barel M |title=RB18A regulates p53-dependent apoptosis. |journal=Oncogene |volume=21 |issue= 6 |pages= 861-6 |year= 2002 |pmid= 11840331 |doi= 10.1038/sj.onc.1205177 }}
*{{cite journal  | author=Kang YK, Guermah M, Yuan CX, Roeder RG |title=The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 5 |pages= 2642-7 |year= 2002 |pmid= 11867769 |doi= 10.1073/pnas.261715899 }}
*{{cite journal  | author=Misra P, Qi C, Yu S, ''et al.'' |title=Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 20011-9 |year= 2002 |pmid= 11912212 |doi= 10.1074/jbc.M201739200 }}
*{{cite journal  | author=Ge K, Guermah M, Yuan CX, ''et al.'' |title=Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. |journal=Nature |volume=417 |issue= 6888 |pages= 563-7 |year= 2002 |pmid= 12037571 |doi= 10.1038/417563a }}
}}
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[[Category:Protein domains]]
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[[Category:Transcription coregulators]]

Revision as of 06:20, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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View/Edit Human

Mediator of RNA polymerase II transcription subunit 1 also known as DRIP205 or Trap220 is a subunit of the Mediator complex and is a protein that in humans is encoded by the MED1 gene.[1][2][3] MED1 functions as a nuclear receptor coactivator.

Med1
Identifiers
SymbolMed1
PfamPF10744
InterProIPR019680

Function

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The mediator of RNA polymerase II transcription subunit 1 protein is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes [e.g., thyroid hormone receptor-(TR-) associated proteins that interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors]. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize.[3]

Interactions

MED1 has been shown to interact with:

Protein family

This entry represents subunit Med1 of the Mediator complex. The Med1 forms part of the Med9 submodule of the Srb/Med complex. It is one of three subunits essential for viability of the whole organism via its role in environmentally-directed cell-fate decisions.[19]

References

  1. ↑ Zhu Y, Qi C, Jain S, Rao MS, Reddy JK (November 1997). "Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor". J Biol Chem. 272 (41): 25500–6. doi:10.1074/jbc.272.41.25500. PMID 9325263.
  2. ↑ Zhu Y, Qi C, Jain S, Le Beau MM, Espinosa R, Atkins GB, Lazar MA, Yeldandi AV, Rao MS, Reddy JK (October 1999). "Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer". Proc Natl Acad Sci U S A. 96 (19): 10848–53. doi:10.1073/pnas.96.19.10848. PMC 17971. PMID 10485914.
  3. ↑ 3.0 3.1 "Entrez Gene: PPARBP PPAR binding protein".
  4. ↑ Wang Q, Sharma D, Ren Y, Fondell JD (November 2002). "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression". J. Biol. Chem. 277 (45): 42852–8. doi:10.1074/jbc.M206061200. PMID 12218053.
  5. ↑ Wada O, Oishi H, Takada I, Yanagisawa J, Yano T, Kato S (August 2004). "BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220". Oncogene. 23 (35): 6000–5. doi:10.1038/sj.onc.1207786. PMID 15208681.
  6. ↑ 6.0 6.1 Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (March 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell. 3 (3): 361–70. doi:10.1016/s1097-2765(00)80463-3. PMID 10198638.
  7. ↑ 7.0 7.1 Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (June 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. doi:10.1016/s0092-8674(03)00436-7. PMID 12837248.
  8. ↑ 8.0 8.1 Kang YK, Guermah M, Yuan CX, Roeder RG (March 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2642–7. doi:10.1073/pnas.261715899. PMC 122401. PMID 11867769.
  9. ↑ Zilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson JA (April 2001). "Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140". Mol. Endocrinol. 15 (4): 501–11. doi:10.1210/mend.15.4.0624. PMID 11266503.
  10. ↑ Hittelman AB, Burakov D, Iñiguez-Lluhí JA, Freedman LP, Garabedian MJ (October 1999). "Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins". EMBO J. 18 (19): 5380–8. doi:10.1093/emboj/18.19.5380. PMC 1171607. PMID 10508170.
  11. ↑ Maeda Y, Rachez C, Hawel L, Byus CV, Freedman LP, Sladek FM (July 2002). "Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205". Mol. Endocrinol. 16 (7): 1502–10. doi:10.1210/mend.16.7.0883. PMID 12089346.
  12. ↑ Malik S, Wallberg AE, Kang YK, Roeder RG (August 2002). "TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4". Mol. Cell. Biol. 22 (15): 5626–37. doi:10.1128/mcb.22.15.5626-5637.2002. PMC 133960. PMID 12101254.
  13. ↑ Frade R, Balbo M, Barel M (December 2000). "RB18A, whose gene is localized on chromosome 17q12-q21.1, regulates in vivo p53 transactivating activity". Cancer Res. 60 (23): 6585–9. PMID 11118038.
  14. ↑ Drané P, Barel M, Balbo M, Frade R (December 1997). "Identification of RB18A, a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53". Oncogene. 15 (25): 3013–24. doi:10.1038/sj.onc.1201492. PMID 9444950.
  15. ↑ Wallberg AE, Yamamura S, Malik S, Spiegelman BM, Roeder RG (November 2003). "Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha". Mol. Cell. 12 (5): 1137–49. doi:10.1016/s1097-2765(03)00391-5. PMID 14636573.
  16. ↑ Kodera Y, Takeyama K, Murayama A, Suzawa M, Masuhiro Y, Kato S (October 2000). "Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators". J. Biol. Chem. 275 (43): 33201–4. doi:10.1074/jbc.C000517200. PMID 10944516.
  17. ↑ Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK (May 2002). "Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation". J. Biol. Chem. 277 (22): 20011–9. doi:10.1074/jbc.M201739200. PMID 11912212.
  18. ↑ Yuan CX, Ito M, Fondell JD, Fu ZY, Roeder RG (July 1998). "The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 7939–44. doi:10.1073/pnas.95.14.7939. PMC 20908. PMID 9653119.
  19. ↑ Boube M, Joulia L, Cribbs DL, Bourbon HM (July 2002). "Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man". Cell. 110 (2): 143–51. doi:10.1016/s0092-8674(02)00830-9. PMID 12150923.

Further reading

This article incorporates text from the public domain Pfam and InterPro: IPR019680
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