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{{Infobox_gene}}
{{PBB_Controls
{{Distinguish | mTORC1}}
| update_page = yes
'''CREB-regulated transcription coactivator 1 (CRTC1)''', previously referred to as '''TORC1''' (''T''ransducer ''O''f ''R''egulated ''C''REB activity ''1''),  is a [[protein]] that in humans is encoded by the ''CRTC1'' [[gene]].<ref name="pmid12539049">{{cite journal | vauthors = Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ | title = t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway | journal = Nature Genetics | volume = 33 | issue = 2 | pages = 208–13 | date = Feb 2003 | pmid = 12539049 | pmc =  | doi = 10.1038/ng1083 }}</ref><ref name="pmid14536081">{{cite journal | vauthors = Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M | title = TORCs: transducers of regulated CREB activity | journal = Molecular Cell | volume = 12 | issue = 2 | pages = 413–23 | date = Aug 2003 | pmid = 14536081 | pmc =  | doi = 10.1016/j.molcel.2003.08.013 }}</ref><ref name="pmid14506290">{{cite journal | vauthors = Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA | title = Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 21 | pages = 12147–52 | date = Oct 2003 | pmid = 14506290 | pmc = 218727 | doi = 10.1073/pnas.1932773100 }}</ref><ref name="entrez">{{cite web|title=Entrez Gene: CRTC1 CREB regulated transcription coactivator 1 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23373 }}</ref> It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands<ref name="url_CRTC1_Atlas">{{cite web | url = http://atlasgeneticsoncology.org/Genes/CRTC1ID471ch19p13.html | title = CRTC1 (CREB regulated transcription coactivator 1) | author = Huret J-L | work = Atlas of Genetics and Cytogenetics in Oncology and Haematology | publisher = INSERM U 935, Genetics, Dept Medical Information, University Hospital of Poitiers }}</ref> and various regions of the adult central nervous system.<ref name="pmid17360587">{{cite journal | vauthors = Kovács KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O, Cardinaux JR | title = TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 11 | pages = 4700–5 | date = Mar 2007 | pmid = 17360587 | pmc = 1838663 | doi = 10.1073/pnas.0607524104 }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Clinical significance ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = CREB regulated transcription coactivator 1
| HGNCid = 16062
| Symbol = CRTC1
| AltSymbols =; FLJ14027; KIAA0616; MECT1; TORC1; WAMTP1
| OMIM = 607536
| ECnumber = 
| Homologene = 41607
| MGIid = 2142523
| GeneAtlas_image1 = PBB_GE_CRTC1_207159_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008140 |text = cAMP response element binding protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23373
    | Hs_Ensembl = ENSG00000105662
    | Hs_RefseqProtein = NP_056136
    | Hs_RefseqmRNA = NM_015321
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 18655488
    | Hs_GenLoc_end = 18749762
    | Hs_Uniprot = Q6UUV9
    | Mm_EntrezGene = 382056
    | Mm_Ensembl = ENSMUSG00000003575
    | Mm_RefseqmRNA = NM_001004062
    | Mm_RefseqProtein = NP_001004062
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 73311344
    | Mm_GenLoc_end = 73368568
    | Mm_Uniprot = Q68ED7
  }}
}}
'''CREB regulated transcription coactivator 1''', also known as '''CRTC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CRTC1 CREB regulated transcription coactivator 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23373| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
Production of CRTC1 is blocked in [[Alzheimer's disease]].<ref name="pmid24760838">{{cite journal | vauthors = Parra-Damas A, Valero J, Chen M, España J, Martín E, Ferrer I, Rodríguez-Alvarez J, Saura CA | title = Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages | journal = The Journal of Neuroscience | volume = 34 | issue = 17 | pages = 5776–87 | date = Apr 2014 | pmid = 24760838 | doi = 10.1523/JNEUROSCI.5288-13.2014 }}</ref>
{{PBB_Summary
TORC1 might be the target protein in ketamin induced anti-depressent effect via NMDA-antagonisation.
| section_title =  
| summary_text =  
}}


==See also==
== See also ==
* [[Transcription coregulator]]
*[[Transcription coregulator]]


==References==
== References ==
{{reflist|2}}
{{Reflist}}
{{-}}
== Further reading ==
{{Refbegin|2}}
* {{cite journal | vauthors = Kovács KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O, Cardinaux JR | title = TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 11 | pages = 4700–5 | date = Mar 2007 | pmid = 17360587 | pmc = 1838663 | doi = 10.1073/pnas.0607524104 }}
* {{cite journal | vauthors = Takemori H, Kajimura J, Okamoto M | title = TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain | journal = The FEBS Journal | volume = 274 | issue = 13 | pages = 3202–9 | date = Jul 2007 | pmid = 17565599 | doi = 10.1111/j.1742-4658.2007.05889.x }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
* {{cite journal | vauthors = Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 3 | pages = 169–76 | date = Jun 1998 | pmid = 9734811 | doi = 10.1093/dnares/5.3.169 }}
* {{cite journal | vauthors = Enlund F, Behboudi A, Andrén Y, Oberg C, Lendahl U, Mark J, Stenman G | title = Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors | journal = Experimental Cell Research | volume = 292 | issue = 1 | pages = 21–8 | date = Jan 2004 | pmid = 14720503 | doi = 10.1016/j.yexcr.2003.09.007 }}
* {{cite journal | vauthors = Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T | title = Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization | journal = Current Biology | volume = 14 | issue = 16 | pages = 1436–50 | date = Aug 2004 | pmid = 15324660 | doi = 10.1016/j.cub.2004.07.051 }}
* {{cite journal | vauthors = Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M | title = The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector | journal = Cell | volume = 119 | issue = 1 | pages = 61–74 | date = Oct 2004 | pmid = 15454081 | doi = 10.1016/j.cell.2004.09.015 }}
* {{cite journal | vauthors = Bittinger MA, McWhinnie E, Meltzer J, Iourgenko V, Latario B, Liu X, Chen CH, Song C, Garza D, Labow M | title = Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins | journal = Current Biology | volume = 14 | issue = 23 | pages = 2156–61 | date = Dec 2004 | pmid = 15589160 | doi = 10.1016/j.cub.2004.11.002 }}
* {{cite journal | vauthors = Behboudi A, Winnes M, Gorunova L, van den Oord JJ, Mertens F, Enlund F, Stenman G | title = Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion | journal = Genes, Chromosomes & Cancer | volume = 43 | issue = 2 | pages = 202–5 | date = Jun 2005 | pmid = 15729701 | doi = 10.1002/gcc.20168 }}
* {{cite journal | vauthors = Komiya T, Park Y, Modi S, Coxon AB, Oh H, Kaye FJ | title = Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation | journal = Oncogene | volume = 25 | issue = 45 | pages = 6128–32 | date = Oct 2006 | pmid = 16652146 | doi = 10.1038/sj.onc.1209627 }}
* {{cite journal | vauthors = Siu YT, Chin KT, Siu KL, Yee Wai Choy E, Jeang KT, Jin DY | title = TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats | journal = Journal of Virology | volume = 80 | issue = 14 | pages = 7052–9 | date = Jul 2006 | pmid = 16809310 | pmc = 1489057 | doi = 10.1128/JVI.00103-06 }}
* {{cite journal | vauthors = Katoh Y, Takemori H, Lin XZ, Tamura M, Muraoka M, Satoh T, Tsuchiya Y, Min L, Doi J, Miyauchi A, Witters LA, Nakamura H, Okamoto M | title = Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade | journal = The FEBS Journal | volume = 273 | issue = 12 | pages = 2730–48 | date = Jun 2006 | pmid = 16817901 | doi = 10.1111/j.1742-4658.2006.05291.x }}
* {{cite journal | vauthors = Okabe M, Miyabe S, Nagatsuka H, Terada A, Hanai N, Yokoi M, Shimozato K, Eimoto T, Nakamura S, Nagai N, Hasegawa Y, Inagaki H | title = MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma | journal = Clinical Cancer Research | volume = 12 | issue = 13 | pages = 3902–7 | date = Jul 2006 | pmid = 16818685 | doi = 10.1158/1078-0432.CCR-05-2376 }}
{{Refend}}


==Further reading==
== External links ==
{{refbegin | 2}}
*{{MeshName|CRTC1+protein,+human}}
{{PBB_Further_reading
* {{UCSC gene info|CRTC1}}
| citations =
*{{cite journal  | author=Takemori H, Kajimura J, Okamoto M |title=TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain. |journal=FEBS J. |volume=274 |issue= 13 |pages= 3202-9 |year= 2007 |pmid= 17565599 |doi= 10.1111/j.1742-4658.2007.05889.x }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | author=Ishikawa K, Nagase T, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169-76 |year= 1998 |pmid= 9734811 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Tonon G, Modi S, Wu L, ''et al.'' |title=t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. |journal=Nat. Genet. |volume=33 |issue= 2 |pages= 208-13 |year= 2003 |pmid= 12539049 |doi= 10.1038/ng1083 }}
*{{cite journal  | author=Iourgenko V, Zhang W, Mickanin C, ''et al.'' |title=Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 21 |pages= 12147-52 |year= 2003 |pmid= 14506290 |doi= 10.1073/pnas.1932773100 }}
*{{cite journal  | author=Conkright MD, Canettieri G, Screaton R, ''et al.'' |title=TORCs: transducers of regulated CREB activity. |journal=Mol. Cell |volume=12 |issue= 2 |pages= 413-23 |year= 2003 |pmid= 14536081 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Enlund F, Behboudi A, Andrén Y, ''et al.'' |title=Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. |journal=Exp. Cell Res. |volume=292 |issue= 1 |pages= 21-8 |year= 2004 |pmid= 14720503 |doi=  }}
*{{cite journal  | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal  | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal  | author=Screaton RA, Conkright MD, Katoh Y, ''et al.'' |title=The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. |journal=Cell |volume=119 |issue= 1 |pages= 61-74 |year= 2004 |pmid= 15454081 |doi= 10.1016/j.cell.2004.09.015 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Bittinger MA, McWhinnie E, Meltzer J, ''et al.'' |title=Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. |journal=Curr. Biol. |volume=14 |issue= 23 |pages= 2156-61 |year= 2005 |pmid= 15589160 |doi= 10.1016/j.cub.2004.11.002 }}
*{{cite journal  | author=Behboudi A, Winnes M, Gorunova L, ''et al.'' |title=Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion. |journal=Genes Chromosomes Cancer |volume=43 |issue= 2 |pages= 202-5 |year= 2005 |pmid= 15729701 |doi= 10.1002/gcc.20168 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Komiya T, Park Y, Modi S, ''et al.'' |title=Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation. |journal=Oncogene |volume=25 |issue= 45 |pages= 6128-32 |year= 2006 |pmid= 16652146 |doi= 10.1038/sj.onc.1209627 }}
*{{cite journal  | author=Siu YT, Chin KT, Siu KL, ''et al.'' |title=TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats. |journal=J. Virol. |volume=80 |issue= 14 |pages= 7052-9 |year= 2006 |pmid= 16809310 |doi= 10.1128/JVI.00103-06 }}
*{{cite journal  | author=Katoh Y, Takemori H, Lin XZ, ''et al.'' |title=Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade. |journal=FEBS J. |volume=273 |issue= 12 |pages= 2730-48 |year= 2006 |pmid= 16817901 |doi= 10.1111/j.1742-4658.2006.05291.x }}
*{{cite journal  | author=Okabe M, Miyabe S, Nagatsuka H, ''et al.'' |title=MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma. |journal=Clin. Cancer Res. |volume=12 |issue= 13 |pages= 3902-7 |year= 2007 |pmid= 16818685 |doi= 10.1158/1078-0432.CCR-05-2376 }}
}}
{{refend}}


==External links==
* {{MeshName|CRTC1+protein,+human}}
{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription coregulators}}
{{Transcription coregulators}}
[[Category:Gene expression]]
[[Category:Gene expression]]
[[Category:Transcription coregulators]]
[[Category:Transcription coregulators]]
{{WikiDoc Sources}}
 
{{gene-19-stub}}

Revision as of 02:04, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human
Not to be confused with mTORC1.

CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (Transducer Of Regulated CREB activity 1), is a protein that in humans is encoded by the CRTC1 gene.[1][2][3][4] It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands[5] and various regions of the adult central nervous system.[6]

Clinical significance

Production of CRTC1 is blocked in Alzheimer's disease.[7] TORC1 might be the target protein in ketamin induced anti-depressent effect via NMDA-antagonisation.

See also

References

  1. ↑ Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ (Feb 2003). "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway". Nature Genetics. 33 (2): 208–13. doi:10.1038/ng1083. PMID 12539049.
  2. ↑ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (Aug 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
  3. ↑ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
  4. ↑ "Entrez Gene: CRTC1 CREB regulated transcription coactivator 1".
  5. ↑ Huret J-L. "CRTC1 (CREB regulated transcription coactivator 1)". Atlas of Genetics and Cytogenetics in Oncology and Haematology. INSERM U 935, Genetics, Dept Medical Information, University Hospital of Poitiers.
  6. ↑ Kovács KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O, Cardinaux JR (Mar 2007). "TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity". Proceedings of the National Academy of Sciences of the United States of America. 104 (11): 4700–5. doi:10.1073/pnas.0607524104. PMC 1838663. PMID 17360587.
  7. ↑ Parra-Damas A, Valero J, Chen M, España J, Martín E, Ferrer I, Rodríguez-Alvarez J, Saura CA (Apr 2014). "Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages". The Journal of Neuroscience. 34 (17): 5776–87. doi:10.1523/JNEUROSCI.5288-13.2014. PMID 24760838.

Further reading

  • Kovács KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O, Cardinaux JR (Mar 2007). "TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity". Proceedings of the National Academy of Sciences of the United States of America. 104 (11): 4700–5. doi:10.1073/pnas.0607524104. PMC 1838663. PMID 17360587.
  • Takemori H, Kajimura J, Okamoto M (Jul 2007). "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain". The FEBS Journal. 274 (13): 3202–9. doi:10.1111/j.1742-4658.2007.05889.x. PMID 17565599.
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  • Enlund F, Behboudi A, Andrén Y, Oberg C, Lendahl U, Mark J, Stenman G (Jan 2004). "Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors". Experimental Cell Research. 292 (1): 21–8. doi:10.1016/j.yexcr.2003.09.007. PMID 14720503.
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
  • Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081.
  • Bittinger MA, McWhinnie E, Meltzer J, Iourgenko V, Latario B, Liu X, Chen CH, Song C, Garza D, Labow M (Dec 2004). "Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins". Current Biology. 14 (23): 2156–61. doi:10.1016/j.cub.2004.11.002. PMID 15589160.
  • Behboudi A, Winnes M, Gorunova L, van den Oord JJ, Mertens F, Enlund F, Stenman G (Jun 2005). "Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion". Genes, Chromosomes & Cancer. 43 (2): 202–5. doi:10.1002/gcc.20168. PMID 15729701.
  • Komiya T, Park Y, Modi S, Coxon AB, Oh H, Kaye FJ (Oct 2006). "Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation". Oncogene. 25 (45): 6128–32. doi:10.1038/sj.onc.1209627. PMID 16652146.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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