PTK6: Difference between revisions

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{{Infobox_gene}}
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'''Tyrosine-protein kinase 6''' is an [[enzyme]] that in humans is encoded by the ''PTK6'' [[gene]].<ref name="pmid8247543">{{cite journal |vauthors=Lee ST, Strunk KM, Spritz RA | title = A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes | journal = Oncogene | volume = 8 | issue = 12 | pages = 3403–10 |date=December 1993 | pmid = 8247543 | pmc =  | doi =  }}</ref><ref name="pmid9284935">{{cite journal |vauthors=Park SH, Lee KH, Kim H, Lee ST | title = Assignment of the human PTK6 gene encoding a non-receptor protein tyrosine kinase to 20q13.3 by fluorescence in situ hybridization | journal = Cytogenet Cell Genet | volume = 77 | issue = 3–4 | pages = 271–2 |date=September 1997 | pmid = 9284935 | pmc =  | doi =10.1159/000134595  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PTK6 PTK6 protein tyrosine kinase 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5753| accessdate = }}</ref>
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== Function ==
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Tyrosine-protein kinase 6 (also known as Breast Tumor Kinase, Brk) is a cytoplasmic non-receptor [[protein kinase]] which may function as an intracellular signal transducer in epithelial tissues. The encoded protein has been shown to undergo autophosphorylation.<ref name="entrez" />
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== Clinical significance ==


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype.  Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue.<ref name="entrez"/>
{{GNF_Protein_box
| image = PBB_Protein_PTK6_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1rja.
| PDB = {{PDB2|1rja}}
| Name = PTK6 protein tyrosine kinase 6
| HGNCid = 9617
| Symbol = PTK6
| AltSymbols =; BRK; FLJ42088
| OMIM = 602004
| ECnumber = 
| Homologene = 68494
| MGIid = 99683
| GeneAtlas_image1 = PBB_GE_PTK6_206482_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004715 |text = non-membrane spanning protein tyrosine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5753
    | Hs_Ensembl = ENSG00000101213
    | Hs_RefseqProtein = NP_005966
    | Hs_RefseqmRNA = NM_005975
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 61630222
    | Hs_GenLoc_end = 61639151
    | Hs_Uniprot = Q13882
    | Mm_EntrezGene = 20459
    | Mm_Ensembl = ENSMUSG00000038751
    | Mm_RefseqmRNA = NM_009184
    | Mm_RefseqProtein = NP_033210
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 181124531
    | Mm_GenLoc_end = 181132196
    | Mm_Uniprot = Q05AA8
  }}
}}
'''PTK6 protein tyrosine kinase 6''', also known as '''PTK6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PTK6 PTK6 protein tyrosine kinase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5753| accessdate = }}</ref>


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==Interactions==
{{PBB_Summary
PTK6 has been shown to [[Protein-protein interaction|interact]] with [[STAP2]]<ref name=pmid10980601>{{cite journal |last=Mitchell |first=P J |authorlink= |author2=Sara E A |author3=Crompton M R  |date=August 2000  |title=A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK |journal=Oncogene |volume=19 |issue=37 |pages=4273–82 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 10980601 |doi = 10.1038/sj.onc.1203775 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[KHDRBS1]].<ref name=pmid10913193>{{cite journal |last=Derry |first=J J |authorlink= |author2=Richard S |author3=Valderrama Carvajal H |author4=Ye X |author5=Vasioukhin V |author6=Cochrane A W |author7=Chen T |author8=Tyner A L  |date=August 2000  |title=Sik (BRK) Phosphorylates Sam68 in the Nucleus and Negatively Regulates Its RNA Binding Ability |journal=Mol. Cell. Biol. |volume=20 |issue=16 |pages=6114–26 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10913193 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/MCB.20.16.6114-6126.2000 |pmc=86087 }}</ref>
| section_title =  
| summary_text = The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation.<ref name="entrez">{{cite web | title = Entrez Gene: PTK6 PTK6 protein tyrosine kinase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5753| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Serfas MS, Tyner AL |title=Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases. |journal=Oncol. Res. |volume=13 |issue= 6-10 |pages= 409-19 |year= 2003 |pmid= 12725532 |doi=  }}
*{{cite journal  |vauthors=Serfas MS, Tyner AL |title=Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases |journal=Oncol. Res. |volume=13 |issue= 6–10 |pages= 409–19 |year= 2003 |pmid= 12725532 |doi=  }}
*{{cite journal | author=Mitchell PJ, Barker KT, Martindale JE, ''et al.'' |title=Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours. |journal=Oncogene |volume=9 |issue= 8 |pages= 2383-90 |year= 1994 |pmid= 8036022 |doi=  }}
*{{cite journal   |vauthors=Mitchell PJ, Barker KT, Martindale JE, etal |title=Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours |journal=Oncogene |volume=9 |issue= 8 |pages= 2383–90 |year= 1994 |pmid= 8036022 |doi=  }}
*{{cite journal | author=Lee ST, Strunk KM, Spritz RA |title=A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. |journal=Oncogene |volume=8 |issue= 12 |pages= 3403-10 |year= 1993 |pmid= 8247543 |doi=  }}
*{{cite journal   |vauthors=Kamalati T, Jolin HE, Mitchell PJ, etal |title=Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor |journal=J. Biol. Chem. |volume=271 |issue= 48 |pages= 30956–63 |year= 1997 |pmid= 8940083 |doi=10.1074/jbc.271.48.30956 }}
*{{cite journal  | author=Kamalati T, Jolin HE, Mitchell PJ, ''et al.'' |title=Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor. |journal=J. Biol. Chem. |volume=271 |issue= 48 |pages= 30956-63 |year= 1997 |pmid= 8940083 |doi= }}
*{{cite journal   |vauthors=Lee H, Kim M, Lee KH, etal |title=Exon-intron structure of the human PTK6 gene demonstrates that PTK6 constitutes a distinct family of non-receptor tyrosine kinase |journal=Mol. Cells |volume=8 |issue= 4 |pages= 401–7 |year= 1998 |pmid= 9749526 |doi=  }}
*{{cite journal  | author=Park SH, Lee KH, Kim H, Lee ST |title=Assignment of the human PTK6 gene encoding a non-receptor protein tyrosine kinase to 20q13.3 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=77 |issue= 3-4 |pages= 271-2 |year= 1997 |pmid= 9284935 |doi= }}
*{{cite journal   |vauthors=Llor X, Serfas MS, Bie W, etal |title=BRK/Sik expression in the gastrointestinal tract and in colon tumors |journal=Clin. Cancer Res. |volume=5 |issue= 7 |pages= 1767–77 |year= 1999 |pmid= 10430081 |doi=  }}
*{{cite journal | author=Lee H, Kim M, Lee KH, ''et al.'' |title=Exon-intron structure of the human PTK6 gene demonstrates that PTK6 constitutes a distinct family of non-receptor tyrosine kinase. |journal=Mol. Cells |volume=8 |issue= 4 |pages= 401-7 |year= 1998 |pmid= 9749526 |doi=  }}
*{{cite journal   |vauthors=Derry JJ, Richard S, Valderrama Carvajal H, etal |title=Sik (BRK) Phosphorylates Sam68 in the Nucleus and Negatively Regulates Its RNA Binding Ability |journal=Mol. Cell. Biol. |volume=20 |issue= 16 |pages= 6114–26 |year= 2000 |pmid= 10913193 |doi=10.1128/MCB.20.16.6114-6126.2000  | pmc=86087 }}
*{{cite journal | author=Llor X, Serfas MS, Bie W, ''et al.'' |title=BRK/Sik expression in the gastrointestinal tract and in colon tumors. |journal=Clin. Cancer Res. |volume=5 |issue= 7 |pages= 1767-77 |year= 1999 |pmid= 10430081 |doi=  }}
*{{cite journal  |vauthors=Mitchell PJ, Sara EA, Crompton MR |title=A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK |journal=Oncogene |volume=19 |issue= 37 |pages= 4273–82 |year= 2000 |pmid= 10980601 |doi= 10.1038/sj.onc.1203775 }}
*{{cite journal | author=Derry JJ, Richard S, Valderrama Carvajal H, ''et al.'' |title=Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability. |journal=Mol. Cell. Biol. |volume=20 |issue= 16 |pages= 6114-26 |year= 2000 |pmid= 10913193 |doi=  }}
*{{cite journal  |vauthors=Kamalati T, Jolin HE, Fry MJ, Crompton MR |title=Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation |journal=Oncogene |volume=19 |issue= 48 |pages= 5471–6 |year= 2000 |pmid= 11114724 |doi= 10.1038/sj.onc.1203931 }}
*{{cite journal  | author=Mitchell PJ, Sara EA, Crompton MR |title=A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK. |journal=Oncogene |volume=19 |issue= 37 |pages= 4273-82 |year= 2000 |pmid= 10980601 |doi= 10.1038/sj.onc.1203775 }}
*{{cite journal   |vauthors=Hong E, Shin J, Bang E, etal |title=Complete sequence-specific 1H, 13C and 15N resonance assignments of the human PTK6 SH2 domain |journal=J. Biomol. NMR |volume=19 |issue= 3 |pages= 291–2 |year= 2001 |pmid= 11330822 |doi=10.1023/A:1011221125013 }}
*{{cite journal  | author=Kamalati T, Jolin HE, Fry MJ, Crompton MR |title=Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation. |journal=Oncogene |volume=19 |issue= 48 |pages= 5471-6 |year= 2000 |pmid= 11114724 |doi= 10.1038/sj.onc.1203931 }}
*{{cite journal   |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal | author=Hong E, Shin J, Bang E, ''et al.'' |title=Complete sequence-specific 1H, 13C and 15N resonance assignments of the human PTK6 SH2 domain. |journal=J. Biomol. NMR |volume=19 |issue= 3 |pages= 291-2 |year= 2001 |pmid= 11330822 |doi=  }}
*{{cite journal  |vauthors=Kang KN, Kim M, Pae KM, Lee ST |title=Characterization of the 5'-flanking region of the human PTK6 gene |journal=Biochim. Biophys. Acta |volume=1574 |issue= 3 |pages= 365–9 |year= 2002 |pmid= 11997104 |doi=  10.1016/s0167-4781(02)00234-8}}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  |vauthors=Qiu H, Miller WT |title=Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34634–41 |year= 2002 |pmid= 12121988 |doi= 10.1074/jbc.M203877200 }}
*{{cite journal  | author=Kang KN, Kim M, Pae KM, Lee ST |title=Characterization of the 5'-flanking region of the human PTK6 gene. |journal=Biochim. Biophys. Acta |volume=1574 |issue= 3 |pages= 365-9 |year= 2002 |pmid= 11997104 |doi=  }}
*{{cite journal  |vauthors=Koo BK, Kim MH, Lee ST, Lee W |title=Purification and spectroscopic characterization of the human protein tyrosine kinase-6 SH3 domain |journal=J. Biochem. Mol. Biol. |volume=35 |issue= 3 |pages= 343–7 |year= 2002 |pmid= 12297019 |doi=10.5483/BMBRep.2002.35.3.343 }}
*{{cite journal  | author=Qiu H, Miller WT |title=Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition. |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34634-41 |year= 2002 |pmid= 12121988 |doi= 10.1074/jbc.M203877200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Koo BK, Kim MH, Lee ST, Lee W |title=Purification and spectroscopic characterization of the human protein tyrosine kinase-6 SH3 domain. |journal=J. Biochem. Mol. Biol. |volume=35 |issue= 3 |pages= 343-7 |year= 2002 |pmid= 12297019 |doi=  }}
*{{cite journal   |vauthors=Coyle JH, Guzik BW, Bor YC, etal |title=Sam68 Enhances the Cytoplasmic Utilization of Intron-Containing RNA and Is Functionally Regulated by the Nuclear Kinase Sik/BRK |journal=Mol. Cell. Biol. |volume=23 |issue= 1 |pages= 92–103 |year= 2003 |pmid= 12482964 |doi=10.1128/MCB.23.1.92-103.2003  | pmc=140664 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Derry JJ, Prins GS, Ray V, Tyner AL |title=Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells |journal=Oncogene |volume=22 |issue= 27 |pages= 4212–20 |year= 2003 |pmid= 12833144 |doi= 10.1038/sj.onc.1206465 }}
*{{cite journal | author=Coyle JH, Guzik BW, Bor YC, ''et al.'' |title=Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK. |journal=Mol. Cell. Biol. |volume=23 |issue= 1 |pages= 92-103 |year= 2003 |pmid= 12482964 |doi=  }}
*{{cite journal  |vauthors=Qiu H, Miller WT |title=Role of the Brk SH3 domain in substrate recognition |journal=Oncogene |volume=23 |issue= 12 |pages= 2216–23 |year= 2004 |pmid= 14676834 |doi= 10.1038/sj.onc.1207339 }}
*{{cite journal  | author=Derry JJ, Prins GS, Ray V, Tyner AL |title=Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells. |journal=Oncogene |volume=22 |issue= 27 |pages= 4212-20 |year= 2003 |pmid= 12833144 |doi= 10.1038/sj.onc.1206465 }}
*{{cite journal  | author=Qiu H, Miller WT |title=Role of the Brk SH3 domain in substrate recognition. |journal=Oncogene |volume=23 |issue= 12 |pages= 2216-23 |year= 2004 |pmid= 14676834 |doi= 10.1038/sj.onc.1207339 }}
}}
}}
{{refend}}
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[[Category:Tyrosine kinases]]
 
 
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Revision as of 18:56, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tyrosine-protein kinase 6 is an enzyme that in humans is encoded by the PTK6 gene.[1][2][3]

Function

Tyrosine-protein kinase 6 (also known as Breast Tumor Kinase, Brk) is a cytoplasmic non-receptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. The encoded protein has been shown to undergo autophosphorylation.[3]

Clinical significance

Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue.[3]

Interactions

PTK6 has been shown to interact with STAP2[4] and KHDRBS1.[5]

References

  1. ↑ Lee ST, Strunk KM, Spritz RA (December 1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". Oncogene. 8 (12): 3403–10. PMID 8247543.
  2. ↑ Park SH, Lee KH, Kim H, Lee ST (September 1997). "Assignment of the human PTK6 gene encoding a non-receptor protein tyrosine kinase to 20q13.3 by fluorescence in situ hybridization". Cytogenet Cell Genet. 77 (3–4): 271–2. doi:10.1159/000134595. PMID 9284935.
  3. ↑ 3.0 3.1 3.2 "Entrez Gene: PTK6 PTK6 protein tyrosine kinase 6".
  4. ↑ Mitchell, P J; Sara E A; Crompton M R (August 2000). "A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK". Oncogene. ENGLAND. 19 (37): 4273–82. doi:10.1038/sj.onc.1203775. ISSN 0950-9232. PMID 10980601.
  5. ↑ Derry, J J; Richard S; Valderrama Carvajal H; Ye X; Vasioukhin V; Cochrane A W; Chen T; Tyner A L (August 2000). "Sik (BRK) Phosphorylates Sam68 in the Nucleus and Negatively Regulates Its RNA Binding Ability". Mol. Cell. Biol. UNITED STATES. 20 (16): 6114–26. doi:10.1128/MCB.20.16.6114-6126.2000. ISSN 0270-7306. PMC 86087. PMID 10913193.

Further reading


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