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{{ | '''Peroxisome proliferator-activated receptor gamma coactivator 1-beta''' is a [[protein]] that in humans is encoded by the ''PPARGC1B'' [[gene]].<ref name="pmid11793024">{{cite journal | vauthors = Ek J, Andersen G, Urhammer SA, Gaede PH, Drivsholm T, Borch-Johnsen K, Hansen T, Pedersen O | title = Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus | journal = Diabetologia | volume = 44 | issue = 12 | pages = 2220–6 |date=Jan 2002 | pmid = 11793024 | pmc = | doi = 10.1007/s001250100032 }}</ref><ref name="pmid11854298">{{cite journal | vauthors = Kressler D, Schreiber SN, Knutti D, Kralli A | title = The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha | journal = J Biol Chem | volume = 277 | issue = 16 | pages = 13918–25 |date=Apr 2002 | pmid = 11854298 | pmc = | doi = 10.1074/jbc.M201134200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=133522| accessdate = }}</ref> | ||
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==See also== | ==See also== | ||
* [[PPARGC1A]] | |||
* [[Peroxisome proliferator-activated receptor]] | |||
* [[Peroxisome proliferator-activated receptor alpha]] | |||
* [[Peroxisome proliferator-activated receptor delta]] | |||
* [[Peroxisome proliferator-activated receptor gamma]] | |||
* [[Transcription coregulator]] | * [[Transcription coregulator]] | ||
==References== | ==References== | ||
{{reflist| | {{reflist}} | ||
==External links== | |||
* {{MeshName|PPARGC1B+protein,+human|3=PPARGC1B protein, human}} | |||
* {{NURSA|C21}} | |||
==Further reading== | ==Further reading== | ||
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*{{cite journal | | *{{cite journal | vauthors=Handschin C, Spiegelman BM |title=Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. |journal=Endocr. Rev. |volume=27 |issue= 7 |pages= 728–35 |year= 2007 |pmid= 17018837 |doi= 10.1210/er.2006-0037 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Esterbauer H, Oberkofler H, Krempler F, Patsch W |title=Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. |journal=Genomics |volume=62 |issue= 1 |pages= 98–102 |year= 2000 |pmid= 10585775 |doi= 10.1006/geno.1999.5977 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Knutti D, Kaul A, Kralli A |title=A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. |journal=Mol. Cell. Biol. |volume=20 |issue= 7 |pages= 2411–22 |year= 2000 |pmid= 10713165 |doi=10.1128/MCB.20.7.2411-2422.2000 | pmc=85422 }} | ||
*{{cite journal | *{{cite journal |vauthors=Lin J, Puigserver P, Donovan J, etal |title=Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. |journal=J. Biol. Chem. |volume=277 |issue= 3 |pages= 1645–8 |year= 2002 |pmid= 11733490 |doi= 10.1074/jbc.C100631200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Lacquemant C, Chikri M, Boutin P, etal |title=No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians. |journal=Diabetologia |volume=45 |issue= 4 |pages= 602–3; author reply 604 |year= 2002 |pmid= 12032643 |doi= 10.1007/s00125-002-0783-z }} | ||
*{{cite journal | *{{cite journal |vauthors=Hara K, Tobe K, Okada T, etal |title=A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes. |journal=Diabetologia |volume=45 |issue= 5 |pages= 740–3 |year= 2003 |pmid= 12107756 |doi= 10.1007/s00125-002-0803-z }} | ||
*{{cite journal | | *{{cite journal | vauthors=Huss JM, Kopp RP, Kelly DP |title=Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40265–74 |year= 2002 |pmid= 12181319 |doi= 10.1074/jbc.M206324200 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Hentschke M, Süsens U, Borgmeyer U |title=PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 5 |pages= 872–9 |year= 2003 |pmid= 12470660 |doi=10.1016/S0006-291X(02)02753-5 }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Shiraki T, Sakai N, Kanaya E, Jingami H |title=Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11344–50 |year= 2003 |pmid= 12551939 |doi= 10.1074/jbc.M212859200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Hammarstedt A, Jansson PA, Wesslau C, etal |title=Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 2 |pages= 578–82 |year= 2003 |pmid= 12565902 |doi=10.1016/S0006-291X(03)00014-7 }} | ||
*{{cite journal | *{{cite journal |vauthors=Meirhaeghe A, Crowley V, Lenaghan C, etal |title=Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo. |journal=Biochem. J. |volume=373 |issue= Pt 1 |pages= 155–65 |year= 2003 |pmid= 12678921 |doi= 10.1042/BJ20030200 | pmc=1223480 }} | ||
*{{cite journal | *{{cite journal |vauthors=Patti ME, Butte AJ, Crunkhorn S, etal |title=Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 14 |pages= 8466–71 |year= 2003 |pmid= 12832613 |doi= 10.1073/pnas.1032913100 | pmc=166252 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ling C, Poulsen P, Carlsson E, etal |title=Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins. |journal=J. Clin. Invest. |volume=114 |issue= 10 |pages= 1518–26 |year= 2004 |pmid= 15546003 |doi= 10.1172/JCI21889 | pmc=525741 }} | ||
*{{cite journal | *{{cite journal |vauthors=Andersen G, Wegner L, Yanagisawa K, etal |title=Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity. |journal=J. Med. Genet. |volume=42 |issue= 5 |pages= 402–7 |year= 2006 |pmid= 15863669 |doi= 10.1136/jmg.2004.026278 | pmc=1736055 }} | ||
*{{cite journal |vauthors=Staiger H, Staiger K, Haas C, etal |title=Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro. |journal=Diabetologia |volume=48 |issue= 10 |pages= 2115–8 |year= 2005 |pmid= 16132959 |doi= 10.1007/s00125-005-1895-z }} | |||
*{{cite journal |vauthors=Wirtenberger M, Tchatchou S, Hemminki K, etal |title=Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer. |journal=Carcinogenesis |volume=27 |issue= 11 |pages= 2201–8 |year= 2006 |pmid= 16704985 |doi= 10.1093/carcin/bgl067 }} | |||
*{{cite journal | |||
*{{cite journal | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{NLM content}} | {{NLM content}} | ||
{{Transcription coregulators}} | {{Transcription coregulators}} | ||
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[[Category:Gene expression]] | [[Category:Gene expression]] | ||
[[Category:Transcription coregulators]] | [[Category:Transcription coregulators]] | ||
{{ | |||
{{gene-5-stub}} | |||
Latest revision as of 18:30, 7 September 2017
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
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| Location (UCSC) | n/a | n/a | |||||
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Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene.[1][2][3]
See also
- PPARGC1A
- Peroxisome proliferator-activated receptor
- Peroxisome proliferator-activated receptor alpha
- Peroxisome proliferator-activated receptor delta
- Peroxisome proliferator-activated receptor gamma
- Transcription coregulator
References
- ↑ Ek J, Andersen G, Urhammer SA, Gaede PH, Drivsholm T, Borch-Johnsen K, Hansen T, Pedersen O (Jan 2002). "Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus". Diabetologia. 44 (12): 2220–6. doi:10.1007/s001250100032. PMID 11793024.
- ↑ Kressler D, Schreiber SN, Knutti D, Kralli A (Apr 2002). "The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha". J Biol Chem. 277 (16): 13918–25. doi:10.1074/jbc.M201134200. PMID 11854298.
- ↑ "Entrez Gene: PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta".
External links
- PPARGC1B protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- NURSA C21
Further reading
- Handschin C, Spiegelman BM (2007). "Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism". Endocr. Rev. 27 (7): 728–35. doi:10.1210/er.2006-0037. PMID 17018837.
- Esterbauer H, Oberkofler H, Krempler F, Patsch W (2000). "Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression". Genomics. 62 (1): 98–102. doi:10.1006/geno.1999.5977. PMID 10585775.
- Knutti D, Kaul A, Kralli A (2000). "A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen". Mol. Cell. Biol. 20 (7): 2411–22. doi:10.1128/MCB.20.7.2411-2422.2000. PMC 85422. PMID 10713165.
- Lin J, Puigserver P, Donovan J, et al. (2002). "Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor". J. Biol. Chem. 277 (3): 1645–8. doi:10.1074/jbc.C100631200. PMID 11733490.
- Lacquemant C, Chikri M, Boutin P, et al. (2002). "No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians". Diabetologia. 45 (4): 602–3, author reply 604. doi:10.1007/s00125-002-0783-z. PMID 12032643.
- Hara K, Tobe K, Okada T, et al. (2003). "A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes". Diabetologia. 45 (5): 740–3. doi:10.1007/s00125-002-0803-z. PMID 12107756.
- Huss JM, Kopp RP, Kelly DP (2002). "Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha". J. Biol. Chem. 277 (43): 40265–74. doi:10.1074/jbc.M206324200. PMID 12181319.
- Hentschke M, Süsens U, Borgmeyer U (2003). "PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma". Biochem. Biophys. Res. Commun. 299 (5): 872–9. doi:10.1016/S0006-291X(02)02753-5. PMID 12470660.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Shiraki T, Sakai N, Kanaya E, Jingami H (2003). "Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state". J. Biol. Chem. 278 (13): 11344–50. doi:10.1074/jbc.M212859200. PMID 12551939.
- Hammarstedt A, Jansson PA, Wesslau C, et al. (2003). "Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance". Biochem. Biophys. Res. Commun. 301 (2): 578–82. doi:10.1016/S0006-291X(03)00014-7. PMID 12565902.
- Meirhaeghe A, Crowley V, Lenaghan C, et al. (2003). "Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo". Biochem. J. 373 (Pt 1): 155–65. doi:10.1042/BJ20030200. PMC 1223480. PMID 12678921.
- Patti ME, Butte AJ, Crunkhorn S, et al. (2003). "Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8466–71. doi:10.1073/pnas.1032913100. PMC 166252. PMID 12832613.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Ling C, Poulsen P, Carlsson E, et al. (2004). "Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins". J. Clin. Invest. 114 (10): 1518–26. doi:10.1172/JCI21889. PMC 525741. PMID 15546003.
- Andersen G, Wegner L, Yanagisawa K, et al. (2006). "Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity". J. Med. Genet. 42 (5): 402–7. doi:10.1136/jmg.2004.026278. PMC 1736055. PMID 15863669.
- Staiger H, Staiger K, Haas C, et al. (2005). "Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro". Diabetologia. 48 (10): 2115–8. doi:10.1007/s00125-005-1895-z. PMID 16132959.
- Wirtenberger M, Tchatchou S, Hemminki K, et al. (2006). "Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer". Carcinogenesis. 27 (11): 2201–8. doi:10.1093/carcin/bgl067. PMID 16704985.
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