VIPoma natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
If left untreated, patients with VIPoma may progress to develop watery [[diarrhea]], [[abdominal pain]], [[bloating]], [[nausea]], [[vomiting]], [[skin rash]], [[backache]], [[flushing]], and [[lethargy]].<ref name="NatanziAmini2009">{{cite journal|last1=Natanzi|first1=Naveed|last2=Amini|first2=Mazyar|last3=Yamini|first3=David|last4=Nielsen|first4=Shawn|last5=Ram|first5=Ramin|title=Vasoactive Intestinal Peptide Tumor|journal=Scholarly Research Exchange|volume=2009|year=2009|pages=1–7|issn=1687-8299|doi=10.3814/2009/938325}}</ref> Common complications of VIPoma include [[metastasis]], [[cardiac arrest]] from low blood [[potassium]] level, and [[dehydration]]. The presence of metastasis is associated with a particularly poor prognosis among patients with VIPoma, with a 5 year survival rate of 20% and 3 year survival rate of 40%.<ref name="SmithBranton1998">{{cite journal|last1=Smith|first1=Stephen L.|last2=Branton|first2=Susan A.|last3=Avino|first3=Anthony J.|last4=Martin|first4=J.Kirk|last5=Klingler|first5=Paul J.|last6=Thompson|first6=Geoffrey B.|last7=Grant|first7=Clive S.|last8=van Heerden|first8=Jon A.|title=Vasoactive intestinal polypeptide secreting islet cell tumors: A 15-year experience and review of the literature|journal=Surgery|volume=124|issue=6|year=1998|pages=1050–1055|issn=00396060|doi=10.1067/msy.1998.92005}}</ref> | If left untreated, patients with VIPoma may progress to develop watery [[diarrhea]], [[abdominal pain]], [[bloating]], [[nausea]], [[vomiting]], [[skin rash]], [[backache]], [[flushing]], and [[lethargy]].<ref name="NatanziAmini2009">{{cite journal|last1=Natanzi|first1=Naveed|last2=Amini|first2=Mazyar|last3=Yamini|first3=David|last4=Nielsen|first4=Shawn|last5=Ram|first5=Ramin|title=Vasoactive Intestinal Peptide Tumor|journal=Scholarly Research Exchange|volume=2009|year=2009|pages=1–7|issn=1687-8299|doi=10.3814/2009/938325}}</ref> Common complications of VIPoma include [[metastasis]], [[cardiac arrest]] from low blood [[potassium]] level, and [[dehydration]]. The presence of metastasis is associated with a particularly poor prognosis among patients with VIPoma, with a 5 year survival rate of 20% and 3 year survival rate of 40%.<ref name="SmithBranton1998">{{cite journal|last1=Smith|first1=Stephen L.|last2=Branton|first2=Susan A.|last3=Avino|first3=Anthony J.|last4=Martin|first4=J.Kirk|last5=Klingler|first5=Paul J.|last6=Thompson|first6=Geoffrey B.|last7=Grant|first7=Clive S.|last8=van Heerden|first8=Jon A.|title=Vasoactive intestinal polypeptide secreting islet cell tumors: A 15-year experience and review of the literature|journal=Surgery|volume=124|issue=6|year=1998|pages=1050–1055|issn=00396060|doi=10.1067/msy.1998.92005}}</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2]Parminder Dhingra, M.D. [3]
Overview
If left untreated, patients with VIPoma may progress to develop watery diarrhea, abdominal pain, bloating, nausea, vomiting, skin rash, backache, flushing, and lethargy.[1] Common complications of VIPoma include metastasis, cardiac arrest from low blood potassium level, and dehydration. The presence of metastasis is associated with a particularly poor prognosis among patients with VIPoma, with a 5 year survival rate of 20% and 3 year survival rate of 40%.[2]
Natural History
- If left untreated, patients with VIPoma may progress to develop watery diarrhea, abdominal pain, bloating, nausea, vomiting, skin rash, backache, flushing, and lethargy.[1]
- VIPoma have a very slow growth rate compared to most malignant tumors.
Complications
Common complications of VIPoma include:
- Metastasis
- Cardiac arrest from low blood potassium level
- Dehydration
Prognosis
- Surgery can usually cure VIPomas. However, in one-third to one-half of patients, the tumor has spread by the time of diagnosis and cannot be cured.
- VIPoma is associated with a 5 year survival rate of 20% and 3 year survival rate of 40%.[2]
References
- ↑ 1.0 1.1 Natanzi, Naveed; Amini, Mazyar; Yamini, David; Nielsen, Shawn; Ram, Ramin (2009). "Vasoactive Intestinal Peptide Tumor". Scholarly Research Exchange. 2009: 1–7. doi:10.3814/2009/938325. ISSN 1687-8299.
- ↑ 2.0 2.1 Smith, Stephen L.; Branton, Susan A.; Avino, Anthony J.; Martin, J.Kirk; Klingler, Paul J.; Thompson, Geoffrey B.; Grant, Clive S.; van Heerden, Jon A. (1998). "Vasoactive intestinal polypeptide secreting islet cell tumors: A 15-year experience and review of the literature". Surgery. 124 (6): 1050–1055. doi:10.1067/msy.1998.92005. ISSN 0039-6060.