Wilson's disease differential diagnosis: Difference between revisions

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==Overview==
==Overview==
Wilson's disease must be differentiated from other diseases that cause jaundice like hemochromatosis, viral hepatitis, alcoholic hepatitis, drug induced hepatitis, and autoimmune hepatitis.
Wilson's disease must be differentiated from other [[diseases]] that cause [[jaundice]] like [[hemochromatosis]], [[viral hepatitis]], [[alcoholic hepatitis]], [[drug]] induced [[hepatitis]], and [[autoimmune hepatitis]].


==Differentiating Wilson's disease from other diseases==
==Differentiating Wilson's disease from other diseases==
Wilson's disease must be differentiated from other diseases that cause jaundice like hemochromatosis, viral hepatitis, alcoholic hepatitis, drug induced hepatitis, and autoimmune hepatitis.<ref name="pmid17370334">{{cite journal| author=Escorsell A, Mas A, de la Mata M, Spanish Group for the Study of Acute Liver Failure| title=Acute liver failure in Spain: analysis of 267 cases. | journal=Liver Transpl | year= 2007 | volume= 13 | issue= 10 | pages= 1389-95 | pmid=17370334 | doi=10.1002/lt.21119 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17370334  }}</ref><ref name="pmid17608778">{{cite journal| author=Bower WA, Johns M, Margolis HS, Williams IT, Bell BP| title=Population-based surveillance for acute liver failure. | journal=Am J Gastroenterol | year= 2007 | volume= 102 | issue= 11 | pages= 2459-63 | pmid=17608778 | doi=10.1111/j.1572-0241.2007.01388.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17608778  }}</ref><ref name="pmid20196116">{{cite journal| author=Kumar R, Shalimar. Bhatia V, Khanal S, Sreenivas V, Gupta SD et al.| title=Antituberculosis therapy-induced acute liver failure: magnitude, profile, prognosis, and predictors of outcome. | journal=Hepatology | year= 2010 | volume= 51 | issue= 5 | pages= 1665-74 | pmid=20196116 | doi=10.1002/hep.23534 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20196116  }}</ref><ref name="pmid22213561">{{cite journal| author=Lee WM, Stravitz RT, Larson AM| title=Introduction to the revised American Association for the Study of Liver Diseases Position Paper on acute liver failure 2011. | journal=Hepatology | year= 2012 | volume= 55 | issue= 3 | pages= 965-7 | pmid=22213561 | doi=10.1002/hep.25551 | pmc=3378702 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22213561  }}</ref>
Wilson's disease must be differentiated from other [[diseases]] that cause [[jaundice]] like [[hemochromatosis]], [[viral hepatitis]], [[alcoholic hepatitis]], [[Drug induced liver injury|drug induced hepatitis]], and [[autoimmune hepatitis]].<ref name="pmid17370334">{{cite journal| author=Escorsell A, Mas A, de la Mata M, Spanish Group for the Study of Acute Liver Failure| title=Acute liver failure in Spain: analysis of 267 cases. | journal=Liver Transpl | year= 2007 | volume= 13 | issue= 10 | pages= 1389-95 | pmid=17370334 | doi=10.1002/lt.21119 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17370334  }}</ref><ref name="pmid17608778">{{cite journal| author=Bower WA, Johns M, Margolis HS, Williams IT, Bell BP| title=Population-based surveillance for acute liver failure. | journal=Am J Gastroenterol | year= 2007 | volume= 102 | issue= 11 | pages= 2459-63 | pmid=17608778 | doi=10.1111/j.1572-0241.2007.01388.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17608778  }}</ref><ref name="pmid20196116">{{cite journal| author=Kumar R, Shalimar. Bhatia V, Khanal S, Sreenivas V, Gupta SD et al.| title=Antituberculosis therapy-induced acute liver failure: magnitude, profile, prognosis, and predictors of outcome. | journal=Hepatology | year= 2010 | volume= 51 | issue= 5 | pages= 1665-74 | pmid=20196116 | doi=10.1002/hep.23534 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20196116  }}</ref><ref name="pmid22213561">{{cite journal| author=Lee WM, Stravitz RT, Larson AM| title=Introduction to the revised American Association for the Study of Liver Diseases Position Paper on acute liver failure 2011. | journal=Hepatology | year= 2012 | volume= 55 | issue= 3 | pages= 965-7 | pmid=22213561 | doi=10.1002/hep.25551 | pmc=3378702 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22213561  }}</ref>
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Revision as of 15:52, 3 January 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

Wilson's disease must be differentiated from other diseases that cause jaundice like hemochromatosis, viral hepatitis, alcoholic hepatitis, drug induced hepatitis, and autoimmune hepatitis.

Differentiating Wilson's disease from other diseases

Wilson's disease must be differentiated from other diseases that cause jaundice like hemochromatosis, viral hepatitis, alcoholic hepatitis, drug induced hepatitis, and autoimmune hepatitis.[1][2][3][4]

Classification of jaundice based on etiology Disease History and clinical manifestations Diagnosis
Lab Findings Other blood tests Other diagnostic
Family history Fever RUQ Pain Pruritis AST ALT ALK BLR Indirect BLR Direct Vcerulloplasmin
Jaundice Hepatocellular Jaundice Hecerulloplasmin ↑Liver biopsyViral hepatitis--/+--↑↑↑N↑/NN+Specific viral antibody for each type-Alcoholic hepatitis----↑↑↑N↑/NN---Drug induced- N ↑/N N - Serum cerulloplasmin ↑ Liver biopsy
Viral hepatitis - -/+ - - ↑↑ N ↑/N N + Specific viral antibody for each type -
Alcoholic hepatitis - - - - ↑↑ N ↑/N N - - -
Drug induced hepatitis - -/+ - - N ↑/N N - - -
Autoimmune hepatitis -/+ - - -/+ N ↑/N N - Anti-LKM antibody Liver biopsy

References

  1. Escorsell A, Mas A, de la Mata M, Spanish Group for the Study of Acute Liver Failure (2007). "Acute liver failure in Spain: analysis of 267 cases". Liver Transpl. 13 (10): 1389–95. doi:10.1002/lt.21119. PMID 17370334.
  2. Bower WA, Johns M, Margolis HS, Williams IT, Bell BP (2007). "Population-based surveillance for acute liver failure". Am J Gastroenterol. 102 (11): 2459–63. doi:10.1111/j.1572-0241.2007.01388.x. PMID 17608778.
  3. Kumar R, Shalimar. Bhatia V, Khanal S, Sreenivas V, Gupta SD; et al. (2010). "Antituberculosis therapy-induced acute liver failure: magnitude, profile, prognosis, and predictors of outcome". Hepatology. 51 (5): 1665–74. doi:10.1002/hep.23534. PMID 20196116.
  4. Lee WM, Stravitz RT, Larson AM (2012). "Introduction to the revised American Association for the Study of Liver Diseases Position Paper on acute liver failure 2011". Hepatology. 55 (3): 965–7. doi:10.1002/hep.25551. PMC 3378702. PMID 22213561.