Wilson's disease history and symptoms: Difference between revisions
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{{CMG}}; {{AE}} {{AEL}} | {{CMG}}; {{AE}} {{AEL}} | ||
==Overview== | ==Overview== | ||
Patients with Wilson's disease may remain asymptomatic until the copper deposits in the liver and brain mainly. Common hepatic symptoms include abdominal distension, abdominal pain, fatigue, bleeding tendency, and esophageal varices. Common neuropsychiatric symptoms include tremors, ataxia, dysarthria, and impulsiveness. Less common symptoms of wilson's disease include urolithiasis and hematuria. | Patients with Wilson's disease may remain [[asymptomatic]] until the [[copper]] deposits in the [[liver]] and [[brain]] mainly. Common [[hepatic]] symptoms include [[abdominal distension]], [[abdominal pain]], [[fatigue]], [[bleeding tendency]], and [[esophageal varices]]. Common [[neuropsychiatric]] symptoms include [[tremors]], [[ataxia]], [[dysarthria]], and impulsiveness. Less common symptoms of wilson's disease include [[urolithiasis]] and [[hematuria]]. | ||
==History == | ==History == | ||
* Family history of Wilson's disease in any other family member is important in the diagnosis as Wilson's disease is usually inhereted. | * [[Family history]] of Wilson's disease in any other family member is important in the [[diagnosis]] as Wilson's disease is usually inhereted. | ||
== Common symptoms == | == Common symptoms == | ||
* Patients with Wilson's disease may remain asymptomatic until the copper deposits in the liver and brain mainly. <ref name="Ala">{{cite journal |author=Ala A, Walker AP, Ashkan K, Dooley JS, Schilsky ML |title=Wilson's disease |journal=Lancet |volume=369 |issue=9559 |pages=397–408 |year=2007 |pmid=17276780|doi=10.1016/S0140-6736(07)60196-2}}</ref> | * Patients with Wilson's disease may remain [[asymptomatic]] until the [[copper]] deposits in the [[liver]] and [[brain]] mainly. <ref name="Ala">{{cite journal |author=Ala A, Walker AP, Ashkan K, Dooley JS, Schilsky ML |title=Wilson's disease |journal=Lancet |volume=369 |issue=9559 |pages=397–408 |year=2007 |pmid=17276780|doi=10.1016/S0140-6736(07)60196-2}}</ref> | ||
* Advanced cases of Wilson's disease can be presented as hepatic failure or chronic liver disease which may be associated with cirrhosis. | * Advanced cases of Wilson's disease can be presented as [[hepatic failure]] or [[chronic liver disease]] which may be associated with [[cirrhosis]]. [[Neurological]] and [[psychiatric]] manifestations are also present in most cases. | ||
* Common symptoms of Wilson's disease include the following: <ref name="Merle2007">{{cite journal |author=Merle U, Schaefer M, Ferenci P, Stremmel W |title=Clinical presentation, diagnosis and long-term outcome of Wilson's disease: a cohort study|journal=Gut |volume=56 |issue=1 |pages=115–20 |year=2007 |pmid=16709660 |doi=10.1136/gut.2005.087262 |url=http://gut.bmj.com/cgi/content/full/56/1/115}}</ref><ref name="pmid22340672">{{cite journal| author=European Association for Study of Liver| title=EASL Clinical Practice Guidelines: Wilson's disease. | journal=J Hepatol | year= 2012 | volume= 56 | issue= 3 | pages= 671-85 | pmid=22340672 | doi=10.1016/j.jhep.2011.11.007 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22340672 }}</ref> | * Common symptoms of Wilson's disease include the following: <ref name="Merle2007">{{cite journal |author=Merle U, Schaefer M, Ferenci P, Stremmel W |title=Clinical presentation, diagnosis and long-term outcome of Wilson's disease: a cohort study|journal=Gut |volume=56 |issue=1 |pages=115–20 |year=2007 |pmid=16709660 |doi=10.1136/gut.2005.087262 |url=http://gut.bmj.com/cgi/content/full/56/1/115}}</ref><ref name="pmid22340672">{{cite journal| author=European Association for Study of Liver| title=EASL Clinical Practice Guidelines: Wilson's disease. | journal=J Hepatol | year= 2012 | volume= 56 | issue= 3 | pages= 671-85 | pmid=22340672 | doi=10.1016/j.jhep.2011.11.007 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22340672 }}</ref> | ||
** '''Hepatic symptoms''': | ** '''[[Hepatic|Hepatic symptoms]]''': | ||
*** Abdominal distension | *** [[Abdominal distension]] | ||
*** Abdominal pain | *** [[Abdominal pain]] | ||
*** Fatigue | *** [[Fatigue]] | ||
*** Bleeding tendency | *** [[Bleeding tendency]] | ||
*** Confusion | *** [[Confusion]] | ||
*** Esophageal varices | *** [[Esophageal varices]] | ||
*** Spider naevi (When associated with cirrhosis) | *** [[Spider naevi]] (When associated with [[cirrhosis]]) | ||
** '''Neuropsychiatric symptoms:''' | ** '''[[Neuropsychiatric|Neuropsychiatric symptoms]]:''' | ||
*** Tremors | *** [[Tremors]] | ||
*** Ataxia | *** [[Ataxia]] | ||
*** Dysarthria | *** [[Dysarthria]] | ||
*** Dystonia | *** [[Dystonia]] | ||
*** Excessive salivation | *** [[Excessive salivation]] | ||
*** Impulsiveness | *** Impulsiveness | ||
*** Schizophrenic disorders | *** [[Schizophrenic disorder|Schizophrenic disorders]] | ||
*** Anxiety | *** [[Anxiety]] | ||
*** Depression | *** [[Depression]] | ||
== Less common symptoms == | == Less common symptoms == | ||
* Less common symptoms of Wilson's disease include the following: | * Less common symptoms of Wilson's disease include the following: | ||
** '''Renal symptoms:''' | ** '''Renal symptoms:''' | ||
*** Urolithiasis | *** [[Urolithiasis]] | ||
*** Hematuria | *** [[Hematuria]] | ||
==References== | ==References== | ||
Revision as of 16:26, 3 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
Patients with Wilson's disease may remain asymptomatic until the copper deposits in the liver and brain mainly. Common hepatic symptoms include abdominal distension, abdominal pain, fatigue, bleeding tendency, and esophageal varices. Common neuropsychiatric symptoms include tremors, ataxia, dysarthria, and impulsiveness. Less common symptoms of wilson's disease include urolithiasis and hematuria.
History
- Family history of Wilson's disease in any other family member is important in the diagnosis as Wilson's disease is usually inhereted.
Common symptoms
- Patients with Wilson's disease may remain asymptomatic until the copper deposits in the liver and brain mainly. [1]
- Advanced cases of Wilson's disease can be presented as hepatic failure or chronic liver disease which may be associated with cirrhosis. Neurological and psychiatric manifestations are also present in most cases.
- Common symptoms of Wilson's disease include the following: [2][3]
Less common symptoms
- Less common symptoms of Wilson's disease include the following:
- Renal symptoms:
References
- ↑ Ala A, Walker AP, Ashkan K, Dooley JS, Schilsky ML (2007). "Wilson's disease". Lancet. 369 (9559): 397–408. doi:10.1016/S0140-6736(07)60196-2. PMID 17276780.
- ↑ Merle U, Schaefer M, Ferenci P, Stremmel W (2007). "Clinical presentation, diagnosis and long-term outcome of Wilson's disease: a cohort study". Gut. 56 (1): 115–20. doi:10.1136/gut.2005.087262. PMID 16709660.
- ↑ European Association for Study of Liver (2012). "EASL Clinical Practice Guidelines: Wilson's disease". J Hepatol. 56 (3): 671–85. doi:10.1016/j.jhep.2011.11.007. PMID 22340672.