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==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
*Immunohistochemical staining may be helpful in the diagnosis of VIPoma. Findings suggestive of VIPoma include positive histochemical staining for:<ref name="urlVasoactive Intestinal Polypeptide Secreting Tumor - VIPoma | | *Immunohistochemical staining may be helpful in the diagnosis of VIPoma. Findings suggestive of VIPoma include positive histochemical staining for:<ref name="urlVasoactive Intestinal Polypeptide Secreting Tumor - VIPoma | ARUPConsult" /> | ||
**Chromogranin A | **Chromogranin A | ||
**Cytokeratin 19 positive stain is an independent marker of aggressive behavior in pancreatic neuroendocrine tumors.<ref name="pmid18684027">{{cite journal| author=Chetty R| title=An overview of practical issues in the diagnosis of gastroenteropancreatic neuroendocrine pathology. | journal=Arch Pathol Lab Med | year= 2008 | volume= 132 | issue= 8 | pages= 1285-9 | pmid=18684027 | doi=10.1043/1543-2165(2008)132[1285:AOOPII]2.0.CO;2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18684027 }}</ref> | **Cytokeratin 19 positive stain is an independent marker of aggressive behavior in pancreatic neuroendocrine tumors.<ref name="pmid18684027">{{cite journal| author=Chetty R| title=An overview of practical issues in the diagnosis of gastroenteropancreatic neuroendocrine pathology. | journal=Arch Pathol Lab Med | year= 2008 | volume= 132 | issue= 8 | pages= 1285-9 | pmid=18684027 | doi=10.1043/1543-2165(2008)132[1285:AOOPII]2.0.CO;2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18684027 }}</ref> | ||
Revision as of 03:45, 8 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2]
Overview
Other diagnostic studies for VIPoma include immunohistochemical staining test, which demonstrates staining for markers such as Chromogranin A, cytokeratin 19, synaptophysin, Ki-67, NSE, PGP 9.5.[1]
Other Diagnostic Studies
- Immunohistochemical staining may be helpful in the diagnosis of VIPoma. Findings suggestive of VIPoma include positive histochemical staining for:[1]
- Chromogranin A
- Cytokeratin 19 positive stain is an independent marker of aggressive behavior in pancreatic neuroendocrine tumors.[2]
- synaptophysin
- Ki-67 (indicates the percentage of neoplastic cells immunolabeled for the marker of proliferation Ki67)
- NSE (neuron-specific enolase)
- PGP 9.5 (protein gene product 9.5)
References
- ↑ 1.0 1.1 "Vasoactive Intestinal Polypeptide Secreting Tumor - VIPoma | ARUPConsult".
- ↑ Chetty R (2008). "An overview of practical issues in the diagnosis of gastroenteropancreatic neuroendocrine pathology". Arch Pathol Lab Med. 132 (8): 1285–9. doi:10.1043/1543-2165(2008)132[1285:AOOPII]2.0.CO;2. PMID 18684027.