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==Overview==
==Overview==
The hallmark of VIPoma is watery [[diarrhea]]. A positive history of [[abdominal pain]], [[weight loss]], [[numbness]], and [[weakness]] is suggestive of VIPoma.<ref name="sss">VIPoma. U.S. National Library of Medicine. Accessed on October 23, 2015. https://www.nlm.nih.gov/medlineplus/ency/article/000228.htm </ref><ref name="pmid16357627">{{cite journal| author=Remme CA, de Groot GH, Schrijver G| title=Diagnosis and treatment of VIPoma in a female patient. | journal=Eur J Gastroenterol Hepatol | year= 2006 | volume= 18 | issue= 1 | pages= 93-9 | pmid=16357627 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16357627  }} </ref><ref name="pmid17510774">{{cite journal| author=Ghaferi AA, Chojnacki KA, Long WD, Cameron JL, Yeo CJ| title=Pancreatic VIPomas: subject review and one institutional experience. | journal=J Gastrointest Surg | year= 2008 | volume= 12 | issue= 2 | pages= 382-93 | pmid=17510774 | doi=10.1007/s11605-007-0177-0 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17510774  }} </ref><ref name="pmid235829162">{{cite journal| author=Ito T, Igarashi H, Jensen RT| title=Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances. | journal=Best Pract Res Clin Gastroenterol | year= 2012 | volume= 26 | issue= 6 | pages= 737-53 | pmid=23582916 | doi=10.1016/j.bpg.2012.12.003 | pmc=3627221 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23582916  }}</ref>
The hallmark of VIPoma is watery [[diarrhea]]. A positive history of [[abdominal pain]], [[weight loss]], [[numbness]], and [[weakness]] is suggestive of VIPoma


==History and Symptoms==
==History and Symptoms==


The hallmark of VIPoma is watery diarrhea. A positive history of abdominal pain, weight loss, numbness, and weakness is suggestive of VIPoma.[1][2][3][4]
The hallmark of VIPoma is watery [[diarrhea]]. A positive history of [[abdominal pain]], [[weight loss]], [[numbness]], and [[weakness]] is suggestive of VIPoma.<ref name="sss">VIPoma. U.S. National Library of Medicine. Accessed on October 23, 2015. https://www.nlm.nih.gov/medlineplus/ency/article/000228.htm </ref><ref name="pmid16357627">{{cite journal| author=Remme CA, de Groot GH, Schrijver G| title=Diagnosis and treatment of VIPoma in a female patient. | journal=Eur J Gastroenterol Hepatol | year= 2006 | volume= 18 | issue= 1 | pages= 93-9 | pmid=16357627 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16357627  }} </ref><ref name="pmid17510774">{{cite journal| author=Ghaferi AA, Chojnacki KA, Long WD, Cameron JL, Yeo CJ| title=Pancreatic VIPomas: subject review and one institutional experience. | journal=J Gastrointest Surg | year= 2008 | volume= 12 | issue= 2 | pages= 382-93 | pmid=17510774 | doi=10.1007/s11605-007-0177-0 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17510774  }} </ref><ref name="pmid235829162">{{cite journal| author=Ito T, Igarashi H, Jensen RT| title=Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances. | journal=Best Pract Res Clin Gastroenterol | year= 2012 | volume= 26 | issue= 6 | pages= 737-53 | pmid=23582916 | doi=10.1016/j.bpg.2012.12.003 | pmc=3627221 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23582916  }}</ref>


===History===
===History===


Patients with VIPoma may have a positive history of:
Patients with VIPoma may have a positive history of:
*Watery diarrhea
*[[Diarrhea|Watery diarrhea]]
*Abdominal pain
*[[Abdominal pain]]
*Weakness
*[[Muscle weakness|Weakness]]


===Common Symptoms===
===Common Symptoms===
Symptoms of VIPoma usually arise when tumor reaches certain size. Most tumors are > 2cm and metastatic by the time symptoms arise. Common symptoms may include any of the following:<ref name="sss">VIPoma. U.S. National Library of Medicine. Accessed on October 23, 2015. https://www.nlm.nih.gov/medlineplus/ency/article/000228.htm </ref><ref name="pmid16357627" /><ref name="pmid17510774">{{cite journal| author=Ghaferi AA, Chojnacki KA, Long WD, Cameron JL, Yeo CJ| title=Pancreatic VIPomas: subject review and one institutional experience. | journal=J Gastrointest Surg | year= 2008 | volume= 12 | issue= 2 | pages= 382-93 | pmid=17510774 | doi=10.1007/s11605-007-0177-0 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17510774  }} </ref><ref name="pmid235829162" />
Symptoms of VIPoma usually arise when tumor reaches certain size. Most tumors are > 2cm and metastatic by the time symptoms arise. Common symptoms may include any of the following:<ref name="sss">VIPoma. U.S. National Library of Medicine. Accessed on October 23, 2015. https://www.nlm.nih.gov/medlineplus/ency/article/000228.htm </ref><ref name="pmid16357627" /><ref name="pmid17510774">{{cite journal| author=Ghaferi AA, Chojnacki KA, Long WD, Cameron JL, Yeo CJ| title=Pancreatic VIPomas: subject review and one institutional experience. | journal=J Gastrointest Surg | year= 2008 | volume= 12 | issue= 2 | pages= 382-93 | pmid=17510774 | doi=10.1007/s11605-007-0177-0 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17510774  }} </ref><ref name="pmid235829162" />
*Watery [[diarrhea]] like cholera and volume ranges from 750ml to more than 3 liters. Secretory diarrhea persists even on fasting for 48 hours and is odorless. The stool appears like dilute tea in color, is blood and mucus free.<ref>Vasoactive Intestinal Peptide Tumor (VIPoma)
*Watery [[diarrhea]] like [[cholera]]
**Volume ranges from 750ml to more than 3 liters.
**Secretory diarrhea persists even on fasting for 48 hours and is odorless.
**The stool appears like dilute tea in color, is blood and mucus free.<ref>Vasoactive Intestinal Peptide Tumor (VIPoma)
Aaron Vinik, MD, PhD, FCP, MACP, FACE
Aaron Vinik, MD, PhD, FCP, MACP, FACE
Murray Waitzer Endowed Chair for Diabetes Research, Professor of Medicine/Pathology/Neurobiology, Director of Research and Neuroendocrine Unit, Division of Endocrine and Metabolic Disorders, Eastern Virginia Medical School, Norfolk, VA</ref>
Murray Waitzer Endowed Chair for Diabetes Research, Professor of Medicine/Pathology/Neurobiology, Director of Research and Neuroendocrine Unit, Division of Endocrine and Metabolic Disorders, Eastern Virginia Medical School, Norfolk, VA</ref>

Revision as of 19:27, 19 January 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2]Parminder Dhingra, M.D. [3]

Overview

The hallmark of VIPoma is watery diarrhea. A positive history of abdominal pain, weight loss, numbness, and weakness is suggestive of VIPoma

History and Symptoms

The hallmark of VIPoma is watery diarrhea. A positive history of abdominal pain, weight loss, numbness, and weakness is suggestive of VIPoma.[1][2][3][4]

History

Patients with VIPoma may have a positive history of:

Common Symptoms

Symptoms of VIPoma usually arise when tumor reaches certain size. Most tumors are > 2cm and metastatic by the time symptoms arise. Common symptoms may include any of the following:[1][2][3][4]

Less Common Symptoms

References

  1. ↑ 1.0 1.1 VIPoma. U.S. National Library of Medicine. Accessed on October 23, 2015. https://www.nlm.nih.gov/medlineplus/ency/article/000228.htm
  2. ↑ 2.0 2.1 Remme CA, de Groot GH, Schrijver G (2006). "Diagnosis and treatment of VIPoma in a female patient". Eur J Gastroenterol Hepatol. 18 (1): 93–9. PMID 16357627.
  3. ↑ 3.0 3.1 Ghaferi AA, Chojnacki KA, Long WD, Cameron JL, Yeo CJ (2008). "Pancreatic VIPomas: subject review and one institutional experience". J Gastrointest Surg. 12 (2): 382–93. doi:10.1007/s11605-007-0177-0. PMID 17510774.
  4. ↑ 4.0 4.1 Ito T, Igarashi H, Jensen RT (2012). "Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances". Best Pract Res Clin Gastroenterol. 26 (6): 737–53. doi:10.1016/j.bpg.2012.12.003. PMC 3627221. PMID 23582916.
  5. ↑ Vasoactive Intestinal Peptide Tumor (VIPoma) Aaron Vinik, MD, PhD, FCP, MACP, FACE Murray Waitzer Endowed Chair for Diabetes Research, Professor of Medicine/Pathology/Neurobiology, Director of Research and Neuroendocrine Unit, Division of Endocrine and Metabolic Disorders, Eastern Virginia Medical School, Norfolk, VA


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