Familial adenomatous polyposis natural history, complications and prognosis: Difference between revisions
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==Natural history== | ==Natural history== | ||
* Familial adenomatous polyposis is a rare disease that | * Familial adenomatous polyposis is a rare disease that usually starts during teenage years.<ref name="KennedyPotter2014">{{cite journal|last1=Kennedy|first1=Raelene D.|last2=Potter|first2=D. Dean|last3=Moir|first3=Christopher R.|last4=El-Youssef|first4=Mounif|title=The natural history of familial adenomatous polyposis syndrome: A 24year review of a single center experience in screening, diagnosis, and outcomes|journal=Journal of Pediatric Surgery|volume=49|issue=1|year=2014|pages=82–86|issn=00223468|doi=10.1016/j.jpedsurg.2013.09.033}}</ref> | ||
* Patients with familial adenomatous polyposis develop hundreds to thousands colon polyps since childhood. | * Patients with familial adenomatous polyposis develop hundreds to thousands colon polyps since childhood. | ||
* They might have upper gastrointestinal polyps. However, progression to malignancy is less than colon polyps. | * They might have upper gastrointestinal polyps. However, progression to malignancy is less than colon polyps. | ||
==Complications== | ==Complications== | ||
Complications that can develop as a result of familial adenomatous polyposis are:<ref name="IaquintoFornasarig2008">{{cite journal|last1=Iaquinto|first1=Gaetano|last2=Fornasarig|first2=Mara|last3=Quaia|first3=Michele|last4=Giardullo|first4=Nicola|last5=D'Onofrio|first5=Vittorio|last6=Iaquinto|first6=Salvatore|last7=Di Bella|first7=Simone|last8=Cannizzaro|first8=Renato|title=Capsule endoscopy is useful and safe for small-bowel surveillance in familial adenomatous polyposis|journal=Gastrointestinal Endoscopy|volume=67|issue=1|year=2008|pages=61–67|issn=00165107|doi=10.1016/j.gie.2007.07.048}}</ref> | Complications that can develop as a result of familial adenomatous polyposis are:<ref name="IaquintoFornasarig2008">{{cite journal|last1=Iaquinto|first1=Gaetano|last2=Fornasarig|first2=Mara|last3=Quaia|first3=Michele|last4=Giardullo|first4=Nicola|last5=D'Onofrio|first5=Vittorio|last6=Iaquinto|first6=Salvatore|last7=Di Bella|first7=Simone|last8=Cannizzaro|first8=Renato|title=Capsule endoscopy is useful and safe for small-bowel surveillance in familial adenomatous polyposis|journal=Gastrointestinal Endoscopy|volume=67|issue=1|year=2008|pages=61–67|issn=00165107|doi=10.1016/j.gie.2007.07.048}}</ref> |
Revision as of 20:30, 29 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2], Mohamad Alkateb, MBBCh [3]
Overview
Natural history
- Familial adenomatous polyposis is a rare disease that usually starts during teenage years.[1]
- Patients with familial adenomatous polyposis develop hundreds to thousands colon polyps since childhood.
- They might have upper gastrointestinal polyps. However, progression to malignancy is less than colon polyps.
Complications
Complications that can develop as a result of familial adenomatous polyposis are:[2]
- Colon cancer
- Duodenal and ampullary cancer
- They are major causes of death after polypectomy
- End-viewing duodenoscopy and side-viewing duodenoscopy are conducted for surveillance.
- Melena
- Cachexia
- Anemia
Prognosis
The prognosis of familial adenomatous polyposis is excellent with treatment. Without treatment, familial adenomatous polyposis will result in colon cancer.
References
- ↑ Kennedy, Raelene D.; Potter, D. Dean; Moir, Christopher R.; El-Youssef, Mounif (2014). "The natural history of familial adenomatous polyposis syndrome: A 24year review of a single center experience in screening, diagnosis, and outcomes". Journal of Pediatric Surgery. 49 (1): 82–86. doi:10.1016/j.jpedsurg.2013.09.033. ISSN 0022-3468.
- ↑ Iaquinto, Gaetano; Fornasarig, Mara; Quaia, Michele; Giardullo, Nicola; D'Onofrio, Vittorio; Iaquinto, Salvatore; Di Bella, Simone; Cannizzaro, Renato (2008). "Capsule endoscopy is useful and safe for small-bowel surveillance in familial adenomatous polyposis". Gastrointestinal Endoscopy. 67 (1): 61–67. doi:10.1016/j.gie.2007.07.048. ISSN 0016-5107.