Cryptogenic organizing pneumonia pathophysiology: Difference between revisions
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*Following an insult, a recovery phase characterized by the organisation of inflammatory exudates with resulting intra-alveolar fibrosis ensues. | *Following an insult, a recovery phase characterized by the organisation of inflammatory exudates with resulting intra-alveolar fibrosis ensues. | ||
*Although the intra-alveolar fibrosis resembles that present in usual interstitial pneumonia (UIP), it is however not associated with irreversible fibrosis. In contrast, cryptogenic organizing pneumonia is characterized by it's favorable response to corticosteroid therapy.<ref name="pmid16880372">{{cite journal| author=Cordier JF| title=Cryptogenic organising pneumonia. | journal=Eur Respir J | year= 2006 | volume= 28 | issue= 2 | pages= 422-46 | pmid=16880372 | doi=10.1183/09031936.06.00013505 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16880372 }} </ref> | *Although the intra-alveolar fibrosis resembles that present in usual interstitial pneumonia (UIP), it is however not associated with irreversible fibrosis. In contrast, cryptogenic organizing pneumonia is characterized by it's favorable response to corticosteroid therapy.<ref name="pmid16880372">{{cite journal| author=Cordier JF| title=Cryptogenic organising pneumonia. | journal=Eur Respir J | year= 2006 | volume= 28 | issue= 2 | pages= 422-46 | pmid=16880372 | doi=10.1183/09031936.06.00013505 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16880372 }} </ref> | ||
==Pathophysiology== | |||
===Pathogenesis=== | |||
*The exact pathogenesis of [disease name] is not fully understood. | |||
OR | |||
*It is understood that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3]. | |||
*[Pathogen name] is usually transmitted via the [transmission route] route to the human host. | |||
*Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell. | |||
*[Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells]. | |||
*The progression to [disease name] usually involves the [molecular pathway]. | |||
*The pathophysiology of [disease/malignancy] depends on the histological subtype. | |||
==Genetics== | |||
*[Disease name] is transmitted in [mode of genetic transmission] pattern. | |||
*Genes involved in the pathogenesis of [disease name] include [gene1], [gene2], and [gene3]. | |||
*The development of [disease name] is the result of multiple genetic mutations. | |||
==Associated Conditions== | |||
==Gross Pathology== | |||
*On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name]. | |||
==Microscopic Pathology== | |||
*On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name]. | |||
==References== | ==References== | ||
Revision as of 02:54, 13 February 2018
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Cryptogenic Organizing Pneumonia Microchapters |
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Differentiating Cryptogenic organizing pneumonia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Serge Korjian M.D.
Overview
Pathophysiology
- The organizing pneumonia pathogenesis model is very similar to the that of cutaneous wound healing.
- Following an insult, a recovery phase characterized by the organisation of inflammatory exudates with resulting intra-alveolar fibrosis ensues.
- Although the intra-alveolar fibrosis resembles that present in usual interstitial pneumonia (UIP), it is however not associated with irreversible fibrosis. In contrast, cryptogenic organizing pneumonia is characterized by it's favorable response to corticosteroid therapy.[1]
Pathophysiology
Pathogenesis
- The exact pathogenesis of [disease name] is not fully understood.
OR
- It is understood that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
- [Pathogen name] is usually transmitted via the [transmission route] route to the human host.
- Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
- [Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
- The progression to [disease name] usually involves the [molecular pathway].
- The pathophysiology of [disease/malignancy] depends on the histological subtype.
Genetics
- [Disease name] is transmitted in [mode of genetic transmission] pattern.
- Genes involved in the pathogenesis of [disease name] include [gene1], [gene2], and [gene3].
- The development of [disease name] is the result of multiple genetic mutations.
Associated Conditions
Gross Pathology
- On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
- On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
References
- ↑ Cordier JF (2006). "Cryptogenic organising pneumonia". Eur Respir J. 28 (2): 422–46. doi:10.1183/09031936.06.00013505. PMID 16880372.