Fat embolism syndrome medical therapy

Fat embolism syndrome Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Fat embolism syndrome from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Fat embolism syndrome medical therapy On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Fat embolism syndrome medical therapy All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Fat embolism syndrome medical therapy
CDC on Fat embolism syndrome medical therapy
Fat embolism syndrome medical therapy in the news
Blogs on Fat embolism syndrome medical therapy
Directions to Hospitals Treating Fat embolism syndrome
Risk calculators and risk factors for Fat embolism syndrome medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Feham Tariq, MD [2]

Medical Therapy

The mainstay of treatment of fat embolism syndrome is supportive care and early thrombolysation. Following are the main steps used for the management:

Conservative management

• In ICU supportive care
• Fluid resuscitation
• Supplemental oxygen
• Mechanical ventilation
• Intracranial monitoring and frequent neurological examination if central nervous system dysfunction is present.

Supplemental oxygen

• High flow supplemental oxygen should be insued to maintain arterial oxygenation.

Anticoagulation

The goals of anticoagulant therapy are as follows:

• It is administered only if the underlying cause is venous thromboembolism.
• Heparin stimulates the activity of lipase which accelerates the clearance of fat from the circulation.

Complications:

• Increased risk of hemorrhage
• Increased production of free fatty acids from fat break down

Fluid resuscitation

The aims of fluid resuscitation are as follows:

• Maintaining intravascular volume
• Binding of fatty acids released into the circulation
• Decrease the lung injury

Albumin along with balanced electrolyte solution is recommended.