Cryptogenic organizing pneumonia laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
*There are no specific laboratory findings associated with [[cryptogenic organizing pneumonia]]. | *There are no specific laboratory findings associated with [[cryptogenic organizing pneumonia]]. | ||
*If there is the history of [[cryptogenic organizing pneumonia]] and patients present with a cough, fever, and dyspnea then following laboratory test | *If there is the history of [[cryptogenic organizing pneumonia]] and patients present with a [[cough]], [[fever]], and [[dyspnea]] then following laboratory test has to be done:<ref name="pmid6647749">{{cite journal |vauthors=Davison AG, Heard BE, McAllister WA, Turner-Warwick ME |title=Cryptogenic organizing pneumonitis |journal=Q. J. Med. |volume=52 |issue=207 |pages=382–94 |date=1983 |pmid=6647749 |doi= |url=}}</ref> | ||
**Complete blood count with differentials- leukocytosis is found in most of the patients.<ref name="pmid8313672">{{cite journal |vauthors=Cordier JF |title=Cryptogenic organizing pneumonitis. Bronchiolitis obliterans organizing pneumonia |journal=Clin. Chest Med. |volume=14 |issue=4 |pages=677–92 |date=December 1993 |pmid=8313672 |doi= |url=}}</ref> | **[[Complete blood count]] with differentials- [[leukocytosis]] is found in most of the patients.<ref name="pmid8313672">{{cite journal |vauthors=Cordier JF |title=Cryptogenic organizing pneumonitis. Bronchiolitis obliterans organizing pneumonia |journal=Clin. Chest Med. |volume=14 |issue=4 |pages=677–92 |date=December 1993 |pmid=8313672 |doi= |url=}}</ref> | ||
**Blood urea nitrogen | **[[Blood urea nitrogen]] | ||
**Creatinine | **[[Creatinine]] | ||
**Urinalysis | **[[Urinalysis]] | ||
**ESR | **[[ESR]] | ||
**C-reactive protein | **[[C-reactive protein]] | ||
*To find the etiology of cryptogenic organizing pneumonia following tests are done: | *To find the etiology of [[cryptogenic organizing pneumonia]] following tests are done: | ||
**Test for antibodies to rule out connective tissue disorder. | **Test for [[antibodies]] to rule out [[connective tissue]] disorder. | ||
***Antinuclear antibody | ***[[Antinuclear antibody]] | ||
***Rheumatoid factor | ***[[Rheumatoid factor]] | ||
***Anti-topoisomerase [anti-Scl70] | ***[[Anti-topoisomerase antibodies|Anti-topoisomerase]] [anti-Scl70] antibodies | ||
***Anti-centromere | ***[[Anti-centromere antibodies]] | ||
***Anti-double-stranded DNA | ***Anti-double-stranded DNA antibodies | ||
***Anti- | ***Anti-J01 antibodies | ||
**To rule out pneumonia, following tests are done:<ref name="pmid26407727">{{cite journal |vauthors=Disayabutr S, Calfee CS, Collard HR, Wolters PJ |title=Interstitial lung diseases in the hospitalized patient |journal=BMC Med |volume=13 |issue= |pages=245 |date=September 2015 |pmid=26407727 |pmc=4584017 |doi=10.1186/s12916-015-0487-0 |url=}}</ref> | **To rule out [[pneumonia]], following tests are done:<ref name="pmid26407727">{{cite journal |vauthors=Disayabutr S, Calfee CS, Collard HR, Wolters PJ |title=Interstitial lung diseases in the hospitalized patient |journal=BMC Med |volume=13 |issue= |pages=245 |date=September 2015 |pmid=26407727 |pmc=4584017 |doi=10.1186/s12916-015-0487-0 |url=}}</ref> | ||
***Blood cultures | ***[[Blood culture|Blood cultures]] | ||
***Sputum gram stain | ***Sputum [[gram stain]] | ||
***Sputum enzyme immunoassay (EIA) | ***Sputum [[Enzyme linked immunosorbent assay (ELISA)|enzyme immunoassay]] (EIA) | ||
***Immunofluorescence | ***[[Immunofluorescence]] | ||
***Polymerase chain reaction (PCR) for respiratory viruses | ***[[Polymerase chain reaction]] (PCR) for respiratory viruses | ||
***Urinary studies for pneumococcal and Legionella antigen | ***Urinary studies for [[pneumococcal]] and [[Legionella]] antigen | ||
***HIV testing | ***[[HIV testing]] | ||
==References== | ==References== | ||
Revision as of 22:27, 6 March 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
Laboratory Findings
- There are no specific laboratory findings associated with cryptogenic organizing pneumonia.
- If there is the history of cryptogenic organizing pneumonia and patients present with a cough, fever, and dyspnea then following laboratory test has to be done:[1]
- Complete blood count with differentials- leukocytosis is found in most of the patients.[2]
- Blood urea nitrogen
- Creatinine
- Urinalysis
- ESR
- C-reactive protein
- To find the etiology of cryptogenic organizing pneumonia following tests are done:
- Test for antibodies to rule out connective tissue disorder.
- Antinuclear antibody
- Rheumatoid factor
- Anti-topoisomerase [anti-Scl70] antibodies
- Anti-centromere antibodies
- Anti-double-stranded DNA antibodies
- Anti-J01 antibodies
- To rule out pneumonia, following tests are done:[3]
- Blood cultures
- Sputum gram stain
- Sputum enzyme immunoassay (EIA)
- Immunofluorescence
- Polymerase chain reaction (PCR) for respiratory viruses
- Urinary studies for pneumococcal and Legionella antigen
- HIV testing
- Test for antibodies to rule out connective tissue disorder.
References
- ↑ Davison AG, Heard BE, McAllister WA, Turner-Warwick ME (1983). "Cryptogenic organizing pneumonitis". Q. J. Med. 52 (207): 382–94. PMID 6647749.
- ↑ Cordier JF (December 1993). "Cryptogenic organizing pneumonitis. Bronchiolitis obliterans organizing pneumonia". Clin. Chest Med. 14 (4): 677–92. PMID 8313672.
- ↑ Disayabutr S, Calfee CS, Collard HR, Wolters PJ (September 2015). "Interstitial lung diseases in the hospitalized patient". BMC Med. 13: 245. doi:10.1186/s12916-015-0487-0. PMC 4584017. PMID 26407727.