Polymyalgia rheumatica laboratory findings: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{CMG}}; {{AE}} {{Rim}} | {{CMG}}; {{AE}} {{Rim}} | ||
{{Polymyalgia rheumatica}} | {{Polymyalgia rheumatica}} | ||
==Overview== | ==Overview== | ||
Polymyalgia rheumatica (PMR) is a clinical diagnosis that is supported by laboratory tests. Elevation in [[C-reactive protein]] (CRP) and/or [[erythrocyte sedimentation rate]] (ESR) is essential for the diagnosis of PMR. | Polymyalgia rheumatica (PMR) is a clinical diagnosis that is supported by laboratory tests. Elevation in [[C-reactive protein]] (CRP) and/or [[erythrocyte sedimentation rate]] (ESR) is essential for the diagnosis of PMR. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
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** Absence of [[anti-citrullinated protein antibody]] (ACPA) | ** Absence of [[anti-citrullinated protein antibody]] (ACPA) | ||
* Other supporting laboratory findings are: | * Other supporting laboratory findings are:<ref name="pmid1807822">{{cite journal |author=Kyle V |title=Laboratory investigations including liver in polymyalgia rheumatica/giant cell arteritis |journal=Baillieres Clin Rheumatol |volume=5 |issue=3 |pages=475–84 |year=1991 |month=December |pmid=1807822 |doi= |url=}}</ref> | ||
** Mild normochromic, normocytic [[anemia]] (during active phase) | ** Mild normochromic, normocytic [[anemia]] (during active phase) | ||
** Normal [[white blood cell]] ([[WBC]]) | ** Normal [[white blood cell]] ([[WBC]]) | ||
** Elevated [[platelet count]] | ** Elevated [[platelet count]] | ||
** Negative [[antinuclear antibody]] (ANA) | ** Negative [[antinuclear antibody]] (ANA) | ||
** Elevated [[alkaline phosphatase]] (detected in one third to half of patients with [[PMR]] associated with [[GCA]]) | ** Elevated [[alkaline phosphatase]] (detected in one third to half of patients with [[PMR]] associated with [[GCA]]) | ||
** Normal [[creatine kinase]] (CK) | ** Normal [[creatine kinase]] (CK) | ||
** Normal [[aldolase]] | ** Normal [[aldolase]] | ||
Revision as of 19:08, 18 April 2018
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]
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Overview
Polymyalgia rheumatica (PMR) is a clinical diagnosis that is supported by laboratory tests. Elevation in C-reactive protein (CRP) and/or erythrocyte sedimentation rate (ESR) is essential for the diagnosis of PMR.
Laboratory Findings
- The following laboratory findings are characteristic of PMR:[1]
- Elevated C-reactive protein (CRP)
- Elevated erythrocyte sedimentation rate (ESR)
- Absence of rheumatoid factor (RF)
- Absence of anti-citrullinated protein antibody (ACPA)
- Other supporting laboratory findings are:[2]
- Mild normochromic, normocytic anemia (during active phase)
- Normal white blood cell (WBC)
- Elevated platelet count
- Negative antinuclear antibody (ANA)
- Elevated alkaline phosphatase (detected in one third to half of patients with PMR associated with GCA)
- Normal creatine kinase (CK)
- Normal aldolase
References
- ↑ Dasgupta B, Cimmino MA, Maradit-Kremers H, Schmidt WA, Schirmer M, Salvarani C; et al. (2012). "2012 provisional classification criteria for polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative". Ann Rheum Dis. 71 (4): 484–92. doi:10.1136/annrheumdis-2011-200329. PMC 3298664. PMID 22388996.
- ↑ Kyle V (1991). "Laboratory investigations including liver in polymyalgia rheumatica/giant cell arteritis". Baillieres Clin Rheumatol. 5 (3): 475–84. PMID 1807822. Unknown parameter
|month=ignored (help)