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==Causes== | ==Causes== | ||
Goodpasture syndrome may be caused by either viral or bacterial infections, occupational, environmental or behavioral risk factors.<ref name="pmid25838905">{{cite journal |vauthors=Cranfield A, Mathavakkannan S |title=Goodpasture's disease following extracorporeal shock wave lithotripsy: a case report & literature review |journal=Clin Case Rep |volume=3 |issue=3 |pages=160–4 |date=March 2015 |pmid=25838905 |pmc=4377247 |doi=10.1002/ccr3.190 |url=}}</ref> | Goodpasture syndrome is an autoimmune condition and is seen in individuals with susceptible HLA sub types who when exposed certain environmental stimuli leads to auto-antibody production. Goodpasture syndrome may be caused by either viral or bacterial infections, occupational, environmental or behavioral risk factors.<ref name="pmid25838905">{{cite journal |vauthors=Cranfield A, Mathavakkannan S |title=Goodpasture's disease following extracorporeal shock wave lithotripsy: a case report & literature review |journal=Clin Case Rep |volume=3 |issue=3 |pages=160–4 |date=March 2015 |pmid=25838905 |pmc=4377247 |doi=10.1002/ccr3.190 |url=}}</ref> | ||
'''Viral and bacterial risk factors causing Goodpasture syndrome''' | '''Viral and bacterial risk factors causing Goodpasture syndrome''' | ||
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It is not clear how bacterial or viral infections play a role in Goodpasture syndrome. However, it is presumed that infections such as the influenza virus may play a role in the disease because of cross-reactivity in the basement membrane.<ref name="pmid4571918">{{cite journal| author=Wilson CB, Dixon FJ| title=Anti-glomerular basement membrane antibody-induced glomerulonephritis. | journal=Kidney Int | year= 1973 | volume= 3 | issue= 2 | pages= 74-89 | pmid=4571918 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4571918 }} </ref> | It is not clear how bacterial or viral infections play a role in Goodpasture syndrome. However, it is presumed that infections such as the influenza virus may play a role in the disease because of cross-reactivity in the basement membrane.<ref name="pmid4571918">{{cite journal| author=Wilson CB, Dixon FJ| title=Anti-glomerular basement membrane antibody-induced glomerulonephritis. | journal=Kidney Int | year= 1973 | volume= 3 | issue= 2 | pages= 74-89 | pmid=4571918 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4571918 }} </ref> | ||
'''Occupational, Environmental and Behavioral risk factors causing Goodpasture syndrome'''<ref name="pmid24456936">{{cite journal| author=Hellmark T, Segelmark M| title=Diagnosis and classification of Goodpasture's disease (anti-GBM). | journal=J Autoimmun | year= 2014 | volume= 48-49 | issue= | pages= 108-12 | pmid=24456936 | doi=10.1016/j.jaut.2014.01.024 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24456936 }} </ref> | '''Occupational, Environmental and Behavioral risk factors causing Goodpasture syndrome'''<ref name="pmid24456936">{{cite journal| author=Hellmark T, Segelmark M| title=Diagnosis and classification of Goodpasture's disease (anti-GBM). | journal=J Autoimmun | year= 2014 | volume= 48-49 | issue= | pages= 108-12 | pmid=24456936 | doi=10.1016/j.jaut.2014.01.024 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24456936 }} </ref><ref name="pmid25349763">{{cite journal| author=Bal A, Das A, Gupta D, Garg M| title=Goodpasture's Syndrome and p-ANCA Associated Vasculitis in a Patient of Silicosiderosis: An Unusual Association. | journal=Case Rep Pulmonol | year= 2014 | volume= 2014 | issue= | pages= 398238 | pmid=25349763 | doi=10.1155/2014/398238 | pmc=4202243 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25349763 }} </ref><ref name="pmid1536151">{{cite journal| author=Bombassei GJ, Kaplan AA| title=The association between hydrocarbon exposure and anti-glomerular basement membrane antibody-mediated disease (Goodpasture's syndrome). | journal=Am J Ind Med | year= 1992 | volume= 21 | issue= 2 | pages= 141-53 | pmid=1536151 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1536151 }} </ref> | ||
<ref name="pmid25349763">{{cite journal| author=Bal A, Das A, Gupta D, Garg M| title=Goodpasture's Syndrome and p-ANCA Associated Vasculitis in a Patient of Silicosiderosis: An Unusual Association. | journal=Case Rep Pulmonol | year= 2014 | volume= 2014 | issue= | pages= 398238 | pmid=25349763 | doi=10.1155/2014/398238 | pmc=4202243 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25349763 }} </ref> | |||
<ref name="pmid1536151">{{cite journal| author=Bombassei GJ, Kaplan AA| title=The association between hydrocarbon exposure and anti-glomerular basement membrane antibody-mediated disease (Goodpasture's syndrome). | journal=Am J Ind Med | year= 1992 | volume= 21 | issue= 2 | pages= 141-53 | pmid=1536151 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1536151 }} </ref> | |||
Occupational, environmental and behavioral risk factors that cause Goodpasture syndrome include: | Occupational, environmental and behavioral risk factors that cause Goodpasture syndrome include: | ||
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[[Category:Autoimmune diseases]] | [[Category:Autoimmune diseases]] | ||
Revision as of 01:11, 22 April 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]
Overview
There are no known direct causes for Goodpasture syndrome. Common risk factors for Goodpasture syndrome are viral or bacterial infections and certain environmental and behavioral risk factors such as smoking, hydrocarbons, formaldehyde and cocaine use.[1]
Causes
Goodpasture syndrome is an autoimmune condition and is seen in individuals with susceptible HLA sub types who when exposed certain environmental stimuli leads to auto-antibody production. Goodpasture syndrome may be caused by either viral or bacterial infections, occupational, environmental or behavioral risk factors.[2]
Viral and bacterial risk factors causing Goodpasture syndrome
It is not clear how bacterial or viral infections play a role in Goodpasture syndrome. However, it is presumed that infections such as the influenza virus may play a role in the disease because of cross-reactivity in the basement membrane.[3]
Occupational, Environmental and Behavioral risk factors causing Goodpasture syndrome[1][4][5]
Occupational, environmental and behavioral risk factors that cause Goodpasture syndrome include:
- Smoking tobacco
- Volatile hydrocarbons
- Exposure to organic solvents
- Upper respiratory tract infections (such as influenza)
- Immunosuppresive drugs such as alemtuzumab
- Cocaine
- Silicosis
- Mineral dust
- D-penicillamine
References
- ↑ 1.0 1.1 Hellmark T, Segelmark M (2014). "Diagnosis and classification of Goodpasture's disease (anti-GBM)". J Autoimmun. 48-49: 108–12. doi:10.1016/j.jaut.2014.01.024. PMID 24456936.
- ↑ Cranfield A, Mathavakkannan S (March 2015). "Goodpasture's disease following extracorporeal shock wave lithotripsy: a case report & literature review". Clin Case Rep. 3 (3): 160–4. doi:10.1002/ccr3.190. PMC 4377247. PMID 25838905.
- ↑ Wilson CB, Dixon FJ (1973). "Anti-glomerular basement membrane antibody-induced glomerulonephritis". Kidney Int. 3 (2): 74–89. PMID 4571918.
- ↑ Bal A, Das A, Gupta D, Garg M (2014). "Goodpasture's Syndrome and p-ANCA Associated Vasculitis in a Patient of Silicosiderosis: An Unusual Association". Case Rep Pulmonol. 2014: 398238. doi:10.1155/2014/398238. PMC 4202243. PMID 25349763.
- ↑ Bombassei GJ, Kaplan AA (1992). "The association between hydrocarbon exposure and anti-glomerular basement membrane antibody-mediated disease (Goodpasture's syndrome)". Am J Ind Med. 21 (2): 141–53. PMID 1536151.