Renal amyloidosis classification: Difference between revisions
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*Vascular amyloid deposition | *Vascular amyloid deposition | ||
*Tubular amyloid deposition | *Tubular amyloid deposition | ||
Renal amyloidosis may be classified according to type of amyloidogenic protein into 3 subtypes: | Renal amyloidosis may be classified according to type of amyloidogenic protein into 3 subtypes:<ref name="pmid23704299">{{cite journal |vauthors=Said SM, Sethi S, Valeri AM, Leung N, Cornell LD, Fidler ME, Herrera Hernandez L, Vrana JA, Theis JD, Quint PS, Dogan A, Nasr SH |title=Renal amyloidosis: origin and clinicopathologic correlations of 474 recent cases |journal=Clin J Am Soc Nephrol |volume=8 |issue=9 |pages=1515–23 |date=September 2013 |pmid=23704299 |pmc=3805078 |doi=10.2215/CJN.10491012 |url=}}</ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
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Revision as of 23:27, 18 June 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]
Overview
Classification
Renal amyloidosis may be classified according to site of amyloid deposition into 3 subtypes:[1]
- Glomerular amyloid deposition (more common and have a poorer prognosis)
- Vascular amyloid deposition
- Tubular amyloid deposition
Renal amyloidosis may be classified according to type of amyloidogenic protein into 3 subtypes:[2]
Amyloidosis type | Amyloidogenic protein | |
---|---|---|
Common types | AL/AHL/AH
(Primary amyloidosis) |
Ig light chains (AL) |
Fragments of Ig heavy chains and light chains (AHL) | ||
Fragments of heavy chains only (AH) | ||
AA
(Secondary amyloidosis) |
Serum amyloid A | |
Rare types | AFib | Fibrinogen A α chain |
AApo AI/AII/AIV | Apo AI, Apo AII, or Apo AIV | |
ATTR | Transthyretin | |
ALys | Lysozyme | |
AGel | Gelsolin | |
ALECT2 | Leukocyte chemotactic factor 2 |
References
- ↑ Bilginer Y, Akpolat T, Ozen S (August 2011). "Renal amyloidosis in children". Pediatr. Nephrol. 26 (8): 1215–27. doi:10.1007/s00467-011-1797-x. PMC 3119800. PMID 21360109.
- ↑ Said SM, Sethi S, Valeri AM, Leung N, Cornell LD, Fidler ME, Herrera Hernandez L, Vrana JA, Theis JD, Quint PS, Dogan A, Nasr SH (September 2013). "Renal amyloidosis: origin and clinicopathologic correlations of 474 recent cases". Clin J Am Soc Nephrol. 8 (9): 1515–23. doi:10.2215/CJN.10491012. PMC 3805078. PMID 23704299.