Renal amyloidosis other diagnostic studies: Difference between revisions
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==Overview== | ==Overview== | ||
==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
=== Kidney biopsy === | |||
*Kidney biopsy can represent amyloid deposition as vascular, tubulo-interstitial and/or glomerular deposits.<ref name="pmid19561448">{{cite journal |vauthors=von Hutten H, Mihatsch M, Lobeck H, Rudolph B, Eriksson M, Röcken C |title=Prevalence and origin of amyloid in kidney biopsies |journal=Am. J. Surg. Pathol. |volume=33 |issue=8 |pages=1198–205 |date=August 2009 |pmid=19561448 |doi=10.1097/PAS.0b013e3181abdfa7 |url=}}</ref> | |||
*In evaluation of kidney biopsy specimens, types of amyloidogenic proteins can be discovered.<ref name="pmid25852856">{{cite journal |vauthors=Khalighi MA, Dean Wallace W, Palma-Diaz MF |title=Amyloid nephropathy |journal=Clin Kidney J |volume=7 |issue=2 |pages=97–106 |date=April 2014 |pmid=25852856 |pmc=4377792 |doi=10.1093/ckj/sfu021 |url=}}</ref> | |||
=== Congo red staining === | |||
* | * All types of amyloidogenic proteins show affinity for Congo red dye, which demonstrates as:<ref name="pmid258528562">{{cite journal |vauthors=Khalighi MA, Dean Wallace W, Palma-Diaz MF |title=Amyloid nephropathy |journal=Clin Kidney J |volume=7 |issue=2 |pages=97–106 |date=April 2014 |pmid=25852856 |pmc=4377792 |doi=10.1093/ckj/sfu021 |url=}}</ref> | ||
** Orange-red appearance by normal light microscopy | |||
** Apple-green birefringence upon polarized light | |||
** | |||
** | |||
==References== | ==References== | ||
Revision as of 19:35, 22 June 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Other Diagnostic Studies
Kidney biopsy
- Kidney biopsy can represent amyloid deposition as vascular, tubulo-interstitial and/or glomerular deposits.[1]
- In evaluation of kidney biopsy specimens, types of amyloidogenic proteins can be discovered.[2]
Congo red staining
- All types of amyloidogenic proteins show affinity for Congo red dye, which demonstrates as:[3]
- Orange-red appearance by normal light microscopy
- Apple-green birefringence upon polarized light
References
- ↑ von Hutten H, Mihatsch M, Lobeck H, Rudolph B, Eriksson M, Röcken C (August 2009). "Prevalence and origin of amyloid in kidney biopsies". Am. J. Surg. Pathol. 33 (8): 1198–205. doi:10.1097/PAS.0b013e3181abdfa7. PMID 19561448.
- ↑ Khalighi MA, Dean Wallace W, Palma-Diaz MF (April 2014). "Amyloid nephropathy". Clin Kidney J. 7 (2): 97–106. doi:10.1093/ckj/sfu021. PMC 4377792. PMID 25852856.
- ↑ Khalighi MA, Dean Wallace W, Palma-Diaz MF (April 2014). "Amyloid nephropathy". Clin Kidney J. 7 (2): 97–106. doi:10.1093/ckj/sfu021. PMC 4377792. PMID 25852856.