Monoclonal gammopathy of undetermined significance classification: Difference between revisions
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'''If the staging system involves specific and characteristic findings and features:''' | '''If the staging system involves specific and characteristic findings and features:''' | ||
There is no established system for the staging of [[Monoclonal gammopathy of undetermined significance]] (MGUS). | |||
There is no established system for the staging of [ | |||
==References== | ==References== | ||
Revision as of 16:10, 2 August 2018
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Monoclonal gammopathy of undetermined significance Microchapters |
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Overview[edit | edit source]
Monoclonal gammopathy of undetermined significance (MGUS) may be classified according to cytogenetic differences into the following subtypes/groups:[1]
Classification[edit | edit source]
Monoclonal gammopathy of undetermined significance (MGUS) may be classified according to cytogenetic differences into the following subtypes/groups:[1]
| Abnormalities in cytogenes | Affected genes |
| IgH translocation: | |
| t(11;14), q(13;32) | cyclin D1 |
| t(4;14)(p16;q32) | FGFR-3, and MMSET |
| t(14;16)(q32;q23) | C-MAF |
| t(6;14)(q32;q11) | MAFB |
| IgH non-translocated : | |
| Hyper diploid | Numerous |
If the staging system involves specific and characteristic findings and features:
There is no established system for the staging of Monoclonal gammopathy of undetermined significance (MGUS).
References
- ↑ 1.0 1.1 Rajkumar SV, Kyle RA, Buadi FK (October 2010). "Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: implications for recategorizing disease entities in the presence of evolving scientific evidence". Mayo Clin. Proc. 85 (10): 945–8. doi:10.4065/mcp.2010.0520. PMC 2947967. PMID 20884827.