Renal amyloidosis risk factors: Difference between revisions
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{{CMG}}; {{AE}} [[User:Okamal|Omer Kamal, M.D.]] [Mailto:okamal@bidmc.harvard.edu| <nowiki>[2]</nowiki>] | {{CMG}}; {{AE}} [[User:Okamal|Omer Kamal, M.D.]] [Mailto:okamal@bidmc.harvard.edu| <nowiki>[2]</nowiki>] | ||
==Overview== | ==Overview== | ||
Common risk factors in the development of | Common risk factors in the development of renal amyloidosis may be environmental and genetic such as heterozygous mutations in the genes for lysozyme, apolipoprotein AI, apolipoprotein AII, or fibrinogen A alpha-chain. | ||
==Risk Factors== | ==Risk Factors== | ||
The most potent risk factor in the development of | The most potent risk factor in the development of renal amyloidosis are genetic . Other risk factors include age.<ref name="pmid19790131" /> | ||
===Common Risk Factors=== | ===Common Risk Factors=== | ||
*Common risk factors in the development of | *Common risk factors in the development of renal amyloidosis may be environmental and genetic. | ||
*Common risk factors in the development of | *Common risk factors in the development of renal amyloidosis include:<ref name="pmid19790131">{{cite journal |vauthors=Obici L, Raimondi S, Lavatelli F, Bellotti V, Merlini G |title=Susceptibility to AA amyloidosis in rheumatic diseases: a critical overview |journal=Arthritis Rheum. |volume=61 |issue=10 |pages=1435–40 |date=October 2009 |pmid=19790131 |doi=10.1002/art.24735 |url=}}</ref><ref name="pmid10036584">{{cite journal |vauthors=Booth DR, Booth SE, Gillmore JD, Hawkins PN, Pepys MB |title=SAA1 alleles as risk factors in reactive systemic AA amyloidosis |journal=Amyloid |volume=5 |issue=4 |pages=262–5 |date=December 1998 |pmid=10036584 |doi= |url=}}</ref> | ||
**Age | **Age | ||
**SAA1 | **SAA1 |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omer Kamal, M.D. [2]
Overview
Common risk factors in the development of renal amyloidosis may be environmental and genetic such as heterozygous mutations in the genes for lysozyme, apolipoprotein AI, apolipoprotein AII, or fibrinogen A alpha-chain.
Risk Factors
The most potent risk factor in the development of renal amyloidosis are genetic . Other risk factors include age.[1]
Common Risk Factors
- Common risk factors in the development of renal amyloidosis may be environmental and genetic.
- Common risk factors in the development of renal amyloidosis include:[1][2]
- Age
- SAA1
- Point mutations in the apoAI gene
- Point mutations in the apoAII gene
- Heterozygous mutations in the genes for lysozyme, apolipoprotein AI, apolipoprotein AII, or fibrinogen A alpha-chain
References
- ↑ 1.0 1.1 Obici L, Raimondi S, Lavatelli F, Bellotti V, Merlini G (October 2009). "Susceptibility to AA amyloidosis in rheumatic diseases: a critical overview". Arthritis Rheum. 61 (10): 1435–40. doi:10.1002/art.24735. PMID 19790131.
- ↑ Booth DR, Booth SE, Gillmore JD, Hawkins PN, Pepys MB (December 1998). "SAA1 alleles as risk factors in reactive systemic AA amyloidosis". Amyloid. 5 (4): 262–5. PMID 10036584.