Monoclonal gammopathy of undetermined significance risk factors: Difference between revisions
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===Common Risk Factors=== | ===Common Risk Factors=== | ||
Common risk factors in the development of [[monoclonal gammopathy of undetermined significance]] include:<ref name="pmid11856795">{{cite journal |vauthors=Kyle RA, Therneau TM, Rajkumar SV, Offord JR, Larson DR, Plevak MF, Melton LJ |title=A long-term study of prognosis in monoclonal gammopathy of undetermined significance |journal=N. Engl. J. Med. |volume=346 |issue=8 |pages=564–9 |date=February 2002 |pmid=11856795 |doi=10.1056/NEJMoa01133202 |url=}}</ref> | Common risk factors in the development of [[monoclonal gammopathy of undetermined significance]] include:<ref name="pmid11856795">{{cite journal |vauthors=Kyle RA, Therneau TM, Rajkumar SV, Offord JR, Larson DR, Plevak MF, Melton LJ |title=A long-term study of prognosis in monoclonal gammopathy of undetermined significance |journal=N. Engl. J. Med. |volume=346 |issue=8 |pages=564–9 |date=February 2002 |pmid=11856795 |doi=10.1056/NEJMoa01133202 |url=}}</ref> | ||
* | * Levels of serum monoclonal protein ≥1.5 g/dL <ref name="pmid11896113">{{cite journal |vauthors=Cesana C, Klersy C, Barbarano L, Nosari AM, Crugnola M, Pungolino E, Gargantini L, Granata S, Valentini M, Morra E |title=Prognostic factors for malignant transformation in monoclonal gammopathy of undetermined significance and smoldering multiple myeloma |journal=J. Clin. Oncol. |volume=20 |issue=6 |pages=1625–34 |date=March 2002 |pmid=11896113 |doi=10.1200/JCO.2002.20.6.1625 |url=}}</ref> | ||
* Non-IgG MGUS (ie, IgA, IgM, IgD MGUS) | * Non-IgG MGUS (ie, IgA, IgM, IgD MGUS) | ||
* Abnormal serum free light chain ratio (ie, ratio of kappa to lambda free light chains <0.26 or >1.65) <ref name="pmid15855274">{{cite journal |vauthors=Rajkumar SV, Kyle RA, Therneau TM, Melton LJ, Bradwell AR, Clark RJ, Larson DR, Plevak MF, Dispenzieri A, Katzmann JA |title=Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance |journal=Blood |volume=106 |issue=3 |pages=812–7 |date=August 2005 |pmid=15855274 |pmc=1895159 |doi=10.1182/blood-2005-03-1038 |url=}}</ref> | * Abnormal serum free light chain ratio (ie, ratio of kappa to lambda free light chains <0.26 or >1.65) <ref name="pmid15855274">{{cite journal |vauthors=Rajkumar SV, Kyle RA, Therneau TM, Melton LJ, Bradwell AR, Clark RJ, Larson DR, Plevak MF, Dispenzieri A, Katzmann JA |title=Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance |journal=Blood |volume=106 |issue=3 |pages=812–7 |date=August 2005 |pmid=15855274 |pmc=1895159 |doi=10.1182/blood-2005-03-1038 |url=}}</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Common risk factors in the development of monoclonal gammopathy of undetermined significance include: serum monoclonal protein level ≥1.5 g/dL ,Non-IgG MGUS (ie, IgA, IgM, IgD MGUS),abnormal serum free light chain ratio (ie, ratio of kappa to lambda free light chains <0.26 or >1.65.
Risk Factors
Common risk factors in the development of monoclonal gammopathy of undetermined significance include: serum monoclonal protein level ≥1.5 g/dL ,Non-IgG MGUS (ie, IgA, IgM, IgD MGUS),abnormal serum free light chain ratio (ie, ratio of kappa to lambda free light chains <0.26 or >1.65.
Common Risk Factors
Common risk factors in the development of monoclonal gammopathy of undetermined significance include:[1]
- Levels of serum monoclonal protein ≥1.5 g/dL [2]
- Non-IgG MGUS (ie, IgA, IgM, IgD MGUS)
- Abnormal serum free light chain ratio (ie, ratio of kappa to lambda free light chains <0.26 or >1.65) [3]
References
- ↑ Kyle RA, Therneau TM, Rajkumar SV, Offord JR, Larson DR, Plevak MF, Melton LJ (February 2002). "A long-term study of prognosis in monoclonal gammopathy of undetermined significance". N. Engl. J. Med. 346 (8): 564–9. doi:10.1056/NEJMoa01133202. PMID 11856795.
- ↑ Cesana C, Klersy C, Barbarano L, Nosari AM, Crugnola M, Pungolino E, Gargantini L, Granata S, Valentini M, Morra E (March 2002). "Prognostic factors for malignant transformation in monoclonal gammopathy of undetermined significance and smoldering multiple myeloma". J. Clin. Oncol. 20 (6): 1625–34. doi:10.1200/JCO.2002.20.6.1625. PMID 11896113.
- ↑ Rajkumar SV, Kyle RA, Therneau TM, Melton LJ, Bradwell AR, Clark RJ, Larson DR, Plevak MF, Dispenzieri A, Katzmann JA (August 2005). "Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance". Blood. 106 (3): 812–7. doi:10.1182/blood-2005-03-1038. PMC 1895159. PMID 15855274.