Monoclonal gammopathy of undetermined significance: Difference between revisions
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==[[Monoclonal gammopathy of undetermined significance differential diagnosis|Differentiating Monoclonal gammopathy of undetermined significance from other Diseases]]== | ==[[Monoclonal gammopathy of undetermined significance differential diagnosis|Differentiating Monoclonal gammopathy of undetermined significance from other Diseases]]== | ||
Several other illnesses can present with a monoclonal gammopathy, and the monoclonal protein may be the first discovery before a formal diagnosis is made like [[multiple myeloma]], [[HIV AIDS|AIDS]], [[chronic lymphocytic leukemia]], [[Non-Hodgkin lymphoma|non-Hodgkin Lymphoma]], particularly [[splenic marginal zone lymphoma]] and lymphoplasmocytic lymphoma. | |||
==[[Monoclonal gammopathy of undetermined significance epidemiology and demographics|Epidemiology and Demographics]]== | ==[[Monoclonal gammopathy of undetermined significance epidemiology and demographics|Epidemiology and Demographics]]== | ||
Revision as of 14:30, 8 August 2018
| Monoclonal gammopathy of undetermined significance | |
| ICD-10 | D47.2 |
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| ICD-9 | 273.1 |
| DiseasesDB | 1341 |
| MeSH | D008998 |
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Monoclonal gammopathy of undetermined significance Microchapters |
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Differentiating Monoclonal gammopathy of undetermined significance from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Monoclonal gammopathy of undetermined significance On the Web |
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American Roentgen Ray Society Images of Monoclonal gammopathy of undetermined significance |
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Monoclonal gammopathy of undetermined significance in the news |
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Directions to Hospitals Treating Monoclonal gammopathy of undetermined significance |
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Risk calculators and risk factors for Monoclonal gammopathy of undetermined significance |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Omer Kamal, M.D. [2]
Synonyms and keywords: Benign monoclonal gammopathy; MGUS; monoclonal gammopathy, benign
Overview
Historical Perspective
Classification
Monoclonal gammopathy of undetermined significance (MGUS) may be classified according to cytogenetic differences into subtypes/groups based on translocations. There is no established system for the staging of Monoclonal gammopathy of undetermined significance (MGUS).
Pathophysiology
Causes
The most common causes of Monoclonal gammopathy of undetermined significance classification are genetic mutations in genes like cyclin D1, FGFR-3, MMSET, C-MAF, and MAFB.
Differentiating Monoclonal gammopathy of undetermined significance from other Diseases
Several other illnesses can present with a monoclonal gammopathy, and the monoclonal protein may be the first discovery before a formal diagnosis is made like multiple myeloma, AIDS, chronic lymphocytic leukemia, non-Hodgkin Lymphoma, particularly splenic marginal zone lymphoma and lymphoplasmocytic lymphoma.
Epidemiology and Demographics
The incidence of Monoclonal gammopathy of undetermined significance is approximately 120 per 100,000 in men at age 50, and goes to 530 per 1000 by the age 90. Women, however, have 60 cases per 1000 at age 50 which goes upto 370 per 1000 at age 90. The prevalence of Monoclonal gammopathy of undetermined significance is different in different populations.
Risk Factors
Common risk factors in the development of monoclonal gammopathy of undetermined significance include African american race, age, male sex, family history, history of immunosuppression and exposure to pesticides.
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies
Treatment
Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies