Renal amyloidosis history and symptoms: Difference between revisions
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*Symptoms of other organ involvement | *Symptoms of other organ involvement | ||
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In renal amyloidosis, most common causes include:<ref name="pmid23704299">{{cite journal |vauthors=Said SM, Sethi S, Valeri AM, Leung N, Cornell LD, Fidler ME, Herrera Hernandez L, Vrana JA, Theis JD, Quint PS, Dogan A, Nasr SH |title=Renal amyloidosis: origin and clinicopathologic correlations of 474 recent cases |journal=Clin J Am Soc Nephrol |volume=8 |issue=9 |pages=1515–23 |date=September 2013 |pmid=23704299 |pmc=3805078 |doi=10.2215/CJN.10491012 |url=}}</ref> | |||
* Idiopathic ( Primary (AL) amyloidosis ) | |||
* Amyloidosis secondary to: | |||
** [[Tuberculosis|TB]] | |||
** [[Familial mediterranean fever|Familial mediterranean fever (FMF)]] | |||
** [[Rheumatoid arthritis|Rheumatoid arthritis (RA)]] | |||
** [[Multiple myeloma]] | |||
===Less Common Causes=== | |||
In renal amyloidosis, less common causes include:<ref name="pmid24497558">{{cite journal |vauthors=Mahmood S, Palladini G, Sanchorawala V, Wechalekar A |title=Update on treatment of light chain amyloidosis |journal=Haematologica |volume=99 |issue=2 |pages=209–21 |date=February 2014 |pmid=24497558 |pmc=3912950 |doi=10.3324/haematol.2013.087619 |url=}}</ref> | |||
*.Hereditary amyloidosis due to amyloidogenic [[Mutation|mutations]]: | |||
** [[Transthyretin|Transthyretin (TTR)]] (most common [[inherited]] [[mutation]]) | |||
** [[Fibrinogen]] | |||
** [[Apolipoprotein A1]] | |||
** [[Apolipoprotein A2]] | |||
** [[Lysozyme]] | |||
** [[Gelsolin]] [[Gene|genes]] | |||
== Symptoms == | == Symptoms == | ||
Revision as of 15:29, 9 August 2018
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Renal amyloidosis Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omer Kamal, M.D. [2]
Overview
The hallmark symptoms of renal amyloidosis is proteinuria and hematuria. Other symptoms include edema, numbness or tingling in hands or feet.
History
Patients with renal amyloidosis may have a positive history of:
- Symptoms of other organ involvement
In renal amyloidosis, most common causes include:[1]
- Idiopathic ( Primary (AL) amyloidosis )
- Amyloidosis secondary to:
Less Common Causes
In renal amyloidosis, less common causes include:[2]
- .Hereditary amyloidosis due to amyloidogenic mutations:
Symptoms
Common Symptoms
Common symptoms of renal amyloidosis include:[3][4]
- Swelling of ankles and legs[3]
- Severe fatigue
- Weakness
- Shortness of breath
- Diarrhea with blood
- Constipation
- Unintentional, significant weight loss
Less Common Symptoms
Less common symptoms of [disease name] include
- Numbness or tingling in hands or feet (carpal tunnel syndrome)
References
- ↑ Said SM, Sethi S, Valeri AM, Leung N, Cornell LD, Fidler ME, Herrera Hernandez L, Vrana JA, Theis JD, Quint PS, Dogan A, Nasr SH (September 2013). "Renal amyloidosis: origin and clinicopathologic correlations of 474 recent cases". Clin J Am Soc Nephrol. 8 (9): 1515–23. doi:10.2215/CJN.10491012. PMC 3805078. PMID 23704299.
- ↑ Mahmood S, Palladini G, Sanchorawala V, Wechalekar A (February 2014). "Update on treatment of light chain amyloidosis". Haematologica. 99 (2): 209–21. doi:10.3324/haematol.2013.087619. PMC 3912950. PMID 24497558.
- ↑ 3.0 3.1 Helin HJ, Korpela MM, Mustonen JT, Pasternack AI (February 1995). "Renal biopsy findings and clinicopathologic correlations in rheumatoid arthritis". Arthritis Rheum. 38 (2): 242–7. PMID 7848315.
- ↑ Triger DR, Joekes AM (January 1973). "Renal amyloidosis--a fourteen-year follow-up". Q. J. Med. 42 (165): 15–40. PMID 4688790.