Monoclonal gammopathy of undetermined significance causes: Difference between revisions
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The most common causes of monoclonal gammopathy of undetermined significance classification are genetic mutations in genes like cyclin D1, FGFR-3, MMSET, C-MAF, and MAFB. | The most common causes of monoclonal gammopathy of undetermined significance classification are genetic mutations in genes like cyclin D1, FGFR-3, MMSET, C-MAF, and MAFB. | ||
== Causes | == Causes == | ||
The most common causes of monoclonal gammopathy of undetermined significance classification are genetic mutations. However, there is no established cause of progression of [[multiple myeloma]] to monoclonal gammopathy of undetermined significance classification. | The most common causes of monoclonal gammopathy of undetermined significance classification are genetic mutations. However, there is no established cause of progression of [[multiple myeloma]] to monoclonal gammopathy of undetermined significance classification. | ||
Revision as of 17:40, 13 August 2018
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Monoclonal gammopathy of undetermined significance Microchapters |
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Template:CMA; Associate Editor(s)-in-Chief: Omer Kamal, M.D.[1]
Overview
The most common causes of monoclonal gammopathy of undetermined significance classification are genetic mutations in genes like cyclin D1, FGFR-3, MMSET, C-MAF, and MAFB.
Causes
The most common causes of monoclonal gammopathy of undetermined significance classification are genetic mutations. However, there is no established cause of progression of multiple myeloma to monoclonal gammopathy of undetermined significance classification.
Genetic causes
| Abnormalities in cytogenes | Affected genes |
| IgH translocation: | |
| t(11;14), q(13;32) | cyclin D1 |
| t(4;14)(p16;q32) | FGFR-3, and MMSET |
| t(14;16)(q32;q23) | C-MAF |
| t(6;14)(q32;q11) | MAFB |
| IgH non-translocated : | |
| Hyper diploid | Numerous |