Monoclonal gammopathy of undetermined significance laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
* Patients may be diagnosed with MGUS if they fulfill the following three criteria:<ref>{{cite journal | author =International Myeloma Working Group | title = Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. | journal = Br J Haematol | volume = 121 | issue = 5 | pages = 749-57 | year = 2003 | id = PMID 12780789}}</ref> | |||
Patients may be diagnosed with MGUS if they fulfill the following three criteria:<ref>{{cite journal | author =International Myeloma Working Group | title = Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. | journal = Br J Haematol | volume = 121 | issue = 5 | pages = 749-57 | year = 2003 | id = PMID 12780789}}</ref> | |||
#A monoclonal [[paraprotein]] band less than 3 g/dl | #A monoclonal [[paraprotein]] band less than 3 g/dl | ||
#[[Plasma cell]]s less than 10% on [[bone marrow examination]] | #[[Plasma cell]]s less than 10% on [[bone marrow examination]] | ||
#No evidence of bone lesions, [[anemia]], [[hypercalcemia]], or [[renal insufficiency]] related to the [[paraprotein]] | #No evidence of bone lesions, [[anemia]], [[hypercalcemia]], or [[renal insufficiency]] related to the [[paraprotein]] | ||
* Check the blood for [[hypercalcemia]] and deterioration in [[renal function]] | |||
Check the blood for [[hypercalcemia]] and deterioration in [[renal function]] | * Urine for [[Bence-Jones]] protein | ||
* Serum [[protein electrophoresis]] and [[immunofixation]] | |||
* The serum free [[light chain]] (FLC) assay in urine [[protein electrophoresis]] and [[immunofixation]]. | |||
* [[Immunoglobulins]] quantitation | |||
==References== | ==References== | ||
Revision as of 14:09, 14 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2]
Overview
Patients may be diagnosed with MGUS if they fulfill the three component criteria which includes a monoclonal paraprotein band less than 3 g/dl, plasma cells less than 10% on bone marrow examination, and no evidence of bone lesions, anemia, hypercalcemia, or renal insufficiency related to the paraprotein. Check the blood for hypercalcemia and deterioration in renal function, check the urine for Bence-Jones protein.
Laboratory Findings
- Patients may be diagnosed with MGUS if they fulfill the following three criteria:[1]
- A monoclonal paraprotein band less than 3 g/dl
- Plasma cells less than 10% on bone marrow examination
- No evidence of bone lesions, anemia, hypercalcemia, or renal insufficiency related to the paraprotein
- Check the blood for hypercalcemia and deterioration in renal function
- Urine for Bence-Jones protein
- Serum protein electrophoresis and immunofixation
- The serum free light chain (FLC) assay in urine protein electrophoresis and immunofixation.
- Immunoglobulins quantitation
References
- ↑ International Myeloma Working Group (2003). "Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group". Br J Haematol. 121 (5): 749–57. PMID 12780789.