Aplastic anemia classification: Difference between revisions
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{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.D.]] [mailto:psingh13579@gmail.com] {{N.F}} | {{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.D.]] [mailto:psingh13579@gmail.com] {{N.F}} | ||
==Overview== | ==Overview== | ||
Aplastic anemia may be classified according to blood cell counts into 3 subgroups, moderately severe aplastic anemia or non severe AA (nSAA), severe aplastic anemia (SAA), and very severe aplastic anemia(vSAA). | |||
==Classification== | ==Classification== | ||
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!vSAA | !vSAA | ||
|- | |- | ||
|Reticulocytes | |[[Reticulocytes]] | ||
|<20G/L | |<20G/L | ||
|<20G/L | |<20G/L | ||
|<20G/L | |<20G/L | ||
|- | |- | ||
|Platelets | |[[Platelet|Platelets]] | ||
|<50 G / L | |<50 G / L | ||
|<20G/L | |<20G/L | ||
|<20G/L | |<20G/L | ||
|- | |- | ||
|Neutrophilic granulocytes | |[[Granulocytes|Neutrophilic granulocytes]] | ||
|<1.0 G / L | |<1.0 G / L | ||
|<0.5G/L | |<0.5G/L | ||
| Line 41: | Line 42: | ||
! | ! | ||
|- | |- | ||
|Idiopathic | |[[Idiopathic]] | ||
| | | | ||
|- | |- | ||
|Secondry | |Secondry | ||
|Irradiation | |[[Irradiation]] | ||
Drugs and chemicals: cytotoxic agents, benzene, chloromphenicol, gold | Drugs and chemicals: cytotoxic agents, [[benzene]], chloromphenicol, [[gold]] | ||
salts, NSAIDS | salts, [[Non-steroidal anti-inflammatory drug|NSAIDS]] | ||
Idiosyncratic reactions | [[Idiosyncratic drug reaction|Idiosyncratic]] reactions | ||
Viruses: Epstein Barr virus, parvovirus B19, HIV | Viruses: [[Epstein Barr virus]], [[parvovirus B19]], [[Human Immunodeficiency Virus (HIV)|HIV]] | ||
Immune diseases | Immune diseases | ||
Pregnancy | [[Pregnancy]] | ||
PNH | [[PNH]] [[Paroxysmal nocturnal hemoglobinuria]] | ||
|- | |- | ||
|'''''Inherited aplastic anemia''''' | |'''''Inherited aplastic anemia''''' | ||
| | |[[Fanconi anemia]] | ||
Dyskeratosis congenital | [[Dyskeratosis congenita|Dyskeratosis congenital]] | ||
Amegakaryocytic thrombocytopenia | [[Amegakaryocytic thrombocytopenia]] | ||
Shwachman-Diamond syndrome | [[Shwachman-Diamond syndrome]] | ||
|} | |} | ||
Revision as of 20:01, 14 August 2018
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Risk calculators and risk factors for Aplastic anemia classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2] Nazia Fuad M.D.
Overview
Aplastic anemia may be classified according to blood cell counts into 3 subgroups, moderately severe aplastic anemia or non severe AA (nSAA), severe aplastic anemia (SAA), and very severe aplastic anemia(vSAA).
Classification
Aplastic anemia may be classified according to blood cell counts into 3 subgroups:[1]
- Moderately severe aplastic anemia or non severe AA (nSAA)
- Severe aplastic anemia (SAA)
- Very severe aplastic anemia(vSAA)
| nSAA | SAA | vSAA | |
|---|---|---|---|
| Reticulocytes | <20G/L | <20G/L | <20G/L |
| Platelets | <50 G / L | <20G/L | <20G/L |
| Neutrophilic granulocytes | <1.0 G / L | <0.5G/L | 0.2G/L |
This classification is of prognostic relevance and has an influence on therapeutic procedures.
| Acquired aplastic anemia | |
|---|---|
| Idiopathic | |
| Secondry | Irradiation
Drugs and chemicals: cytotoxic agents, benzene, chloromphenicol, gold salts, NSAIDS Idiosyncratic reactions Viruses: Epstein Barr virus, parvovirus B19, HIV Immune diseases |
| Inherited aplastic anemia | Fanconi anemia |
References
- ↑ Dolberg OJ, Levy Y (2014). "Idiopathic aplastic anemia: diagnosis and classification". Autoimmun Rev. 13 (4–5): 569–73. doi:10.1016/j.autrev.2014.01.014. PMID 24424170.