MiR-208: Difference between revisions
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'''miR-208''' is a family of [[microRNA]] precursors found in [[animal]]s, including [[human]]s. The ~22 [[nucleotide]] mature miRNA sequence is excised from the precursor hairpin by the enzyme [[Dicer]].<ref>{{cite journal|last=Ambros|first=V|title=microRNAs: tiny regulators with great potential | '''miR-208''' is a family of [[microRNA]] precursors found in [[animal]]s, including [[human]]s. The ~22 [[nucleotide]] mature miRNA sequence is excised from the precursor hairpin by the enzyme [[Dicer]].<ref>{{cite journal |last=Ambros |first=V |title=microRNAs: tiny regulators with great potential |journal=Cell |date=2001-12-28 |volume=107 |issue=7 |pages=823–6 |pmid=11779458 |doi=10.1016/S0092-8674(01)00616-X}}</ref> This sequence then associates with [[RNA-induced silencing complex|RISC]] which effects [[RNA interference]].<ref>{{cite journal |last=Gregory |first=RI |author2=Chendrimada, TP |author3=Cooch, N |author4=Shiekhattar, R |title=Human RISC couples microRNA biogenesis and posttranscriptional gene silencing |journal=Cell |date=2005-11-18 |volume=123 |issue=4 |pages=631–40 |pmid=16271387 |doi=10.1016/j.cell.2005.10.022}}</ref> | ||
In humans, the [[gene]] for miR-208 is located in an [[intron]] of [[MYH7]].<ref name="Mal11">{{cite journal|last=Malizia|first=AP|author2=Wang, DZ|title=MicroRNAs in cardiomyocyte development | In humans, the [[gene]] for miR-208 is located in an [[intron]] of [[MYH7]].<ref name="Mal11">{{cite journal |last=Malizia |first=AP |author2=Wang, DZ |title=MicroRNAs in cardiomyocyte development |journal=Wiley Interdisciplinary Reviews: Systems Biology and Medicine |date=Mar–Apr 2011 |volume=3 |issue=2 |pages=183–90 |pmid=21305703 |doi=10.1002/wsbm.111 |pmc=3058499}}</ref> | ||
==Function== | ==Function== | ||
miR-208 has been deemed a "myomiR"<ref name="Mal11" /> as it is specifically expressed, or found at much higher levels, in [[heart|cardiac tissue]]. Other myomiRs include [[Mir-1 microRNA precursor family|miR-1]] and [[Mir-133 microRNA precursor family|miR-133]].<ref name="Mal11" /> miR-208 is thought to be dysregulated in various [[cardiovascular disease]]s.<ref>{{cite journal|last=Cai|first=B|author2=Pan, Z |author3=Lu, Y |title=The roles of microRNAs in heart diseases: a novel important regulator | miR-208 has been deemed a "myomiR"<ref name="Mal11" /> as it is specifically expressed, or found at much higher levels, in [[heart|cardiac tissue]]. Other myomiRs include [[Mir-1 microRNA precursor family|miR-1]] and [[Mir-133 microRNA precursor family|miR-133]].<ref name="Mal11" /> miR-208 is thought to be dysregulated in various [[cardiovascular disease]]s.<ref>{{cite journal |last=Cai |first=B |author2=Pan, Z |author3=Lu, Y |title=The roles of microRNAs in heart diseases: a novel important regulator |journal=Current Medicinal Chemistry |year=2010 |volume=17 |issue=5 |pages=407–11 |pmid=20015039 |doi=10.2174/092986710790226129}}{{subscription}}</ref><ref>{{cite journal |last=Han |first=M |author2=Toli, J |author3=Abdellatif, M |title=MicroRNAs in the cardiovascular system. |journal=Current Opinion in Cardiology |date=May 2011 |volume=26 |issue=3 |pages=181–9 |pmid=21464712 |doi=10.1097/HCO.0b013e328345983d}}</ref> | ||
miR-208 functions in [[cardiomyocyte]]s regulating the production of the [[myosin heavy chain]] during development.<ref name="Mal11" /> It also responds to stress and forms part of a [[hormone|hormonal]] signalling cascade in cardiac cells.<ref>{{cite journal|last=van Rooij|first=E |author2=Sutherland, LB |author3=Qi, X |author4=Richardson, JA |author5=Hill, J |author6=Olson, EN|title=Control of stress-dependent cardiac growth and gene expression by a microRNA | miR-208 functions in [[cardiomyocyte]]s regulating the production of the [[myosin heavy chain]] during development.<ref name="Mal11" /> It also responds to stress and forms part of a [[hormone|hormonal]] signalling cascade in cardiac cells.<ref>{{cite journal |last=van Rooij |first=E |author2=Sutherland, LB |author3=Qi, X |author4=Richardson, JA |author5=Hill, J |author6=Olson, EN |title=Control of stress-dependent cardiac growth and gene expression by a microRNA |journal=Science |date=2007-04-27 |volume=316 |issue=5824 |pages=575–9 |pmid=17379774 |doi=10.1126/science.1139089}}</ref> | ||
==Applications== | ==Applications== | ||
A preliminary study has shown a potential use in the [[prognosis]] of [[dilated cardiomyopathy]].<ref>{{cite journal|last=Satoh|first=M|author2=Minami, Y |author3=Takahashi, Y |author4=Tabuchi, T |author5=Nakamura, M |title=Expression of microRNA-208 is associated with adverse clinical outcomes in human dilated cardiomyopathy | A preliminary study has shown a potential use in the [[prognosis]] of [[dilated cardiomyopathy]].<ref>{{cite journal |last=Satoh |first=M |author2=Minami, Y |author3=Takahashi, Y |author4=Tabuchi, T |author5=Nakamura, M |title=Expression of microRNA-208 is associated with adverse clinical outcomes in human dilated cardiomyopathy |journal=Journal of Cardiac Failure |date=May 2010 |volume=16 |issue=5 |pages=404–10 |pmid=20447577 |doi=10.1016/j.cardfail.2010.01.002}}</ref> Another application has been suggested as using plasma concentration of miR-208 as a [[biomarker]] of damaged [[cardiac muscle]] cells.<ref>{{cite journal |last=Ji |first=X |author2=Takahashi, R |author3=Hiura, Y |author4=Hirokawa, G |author5=Fukushima, Y |author6=Iwai, N |title=Plasma miR-208 as a biomarker of myocardial injury |journal=Clinical Chemistry |date=Nov 2009 |volume=55 |issue=11 |pages=1944–9 |pmid=19696117 |doi=10.1373/clinchem.2009.125310}}</ref> | ||
==References== | ==References== | ||
| Line 41: | Line 41: | ||
==Further reading== | ==Further reading== | ||
{{refbegin}} | {{refbegin}} | ||
*{{cite journal|last=Kukreja|first=RC|author2=Yin, C |author3=Salloum, FN |title=MicroRNA – New Players in Cardiac Injury and Protection | *{{cite journal |last=Kukreja |first=RC |author2=Yin, C |author3=Salloum, FN |title=MicroRNA – New Players in Cardiac Injury and Protection |journal=Molecular Pharmacology |date=2011-07-07 |pmid=21737570 |doi=10.1124/mol.111.073528 |volume=80 |issue=4 |pmc=3187527 |pages=558–64}} | ||
{{refend}} | {{refend}} | ||
{{miRNA precursor families}} | {{miRNA precursor families}} | ||
[[Category:MicroRNA]] | [[Category:MicroRNA]] | ||
Revision as of 00:45, 13 November 2018
| miR-208 | |
|---|---|
| File:Mir-208 SS.png Conserved secondary structure of miR-208 microRNA precursor | |
| Identifiers | |
| Symbol | miR-208 |
| Alt. Symbols | MIR208 |
| Rfam | RF00749 |
| miRBase | MI0000251 |
| miRBase family | MIPF0000178 |
| Entrez | 406990 |
| HUGO | 31585 |
| OMIM | 611116 |
| RefSeq | NR_029595 |
| Other data | |
| RNA type | miRNA |
| Domain(s) | Metazoa |
| GO | 0035195 |
| SO | 0001244 |
| Locus | Chr. 14 q11.2 |
| PDB structures | PDBe |
miR-208 is a family of microRNA precursors found in animals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] This sequence then associates with RISC which effects RNA interference.[2]
In humans, the gene for miR-208 is located in an intron of MYH7.[3]
Function
miR-208 has been deemed a "myomiR"[3] as it is specifically expressed, or found at much higher levels, in cardiac tissue. Other myomiRs include miR-1 and miR-133.[3] miR-208 is thought to be dysregulated in various cardiovascular diseases.[4][5]
miR-208 functions in cardiomyocytes regulating the production of the myosin heavy chain during development.[3] It also responds to stress and forms part of a hormonal signalling cascade in cardiac cells.[6]
Applications
A preliminary study has shown a potential use in the prognosis of dilated cardiomyopathy.[7] Another application has been suggested as using plasma concentration of miR-208 as a biomarker of damaged cardiac muscle cells.[8]
References
- ↑ Ambros, V (2001-12-28). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823–6. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
- ↑ Gregory, RI; Chendrimada, TP; Cooch, N; Shiekhattar, R (2005-11-18). "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing". Cell. 123 (4): 631–40. doi:10.1016/j.cell.2005.10.022. PMID 16271387.
- ↑ 3.0 3.1 3.2 3.3 Malizia, AP; Wang, DZ (Mar–Apr 2011). "MicroRNAs in cardiomyocyte development". Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 3 (2): 183–90. doi:10.1002/wsbm.111. PMC 3058499. PMID 21305703.
- ↑ Cai, B; Pan, Z; Lu, Y (2010). "The roles of microRNAs in heart diseases: a novel important regulator". Current Medicinal Chemistry. 17 (5): 407–11. doi:10.2174/092986710790226129. PMID 20015039.(subscription required)
- ↑ Han, M; Toli, J; Abdellatif, M (May 2011). "MicroRNAs in the cardiovascular system". Current Opinion in Cardiology. 26 (3): 181–9. doi:10.1097/HCO.0b013e328345983d. PMID 21464712.
- ↑ van Rooij, E; Sutherland, LB; Qi, X; Richardson, JA; Hill, J; Olson, EN (2007-04-27). "Control of stress-dependent cardiac growth and gene expression by a microRNA". Science. 316 (5824): 575–9. doi:10.1126/science.1139089. PMID 17379774.
- ↑ Satoh, M; Minami, Y; Takahashi, Y; Tabuchi, T; Nakamura, M (May 2010). "Expression of microRNA-208 is associated with adverse clinical outcomes in human dilated cardiomyopathy". Journal of Cardiac Failure. 16 (5): 404–10. doi:10.1016/j.cardfail.2010.01.002. PMID 20447577.
- ↑ Ji, X; Takahashi, R; Hiura, Y; Hirokawa, G; Fukushima, Y; Iwai, N (Nov 2009). "Plasma miR-208 as a biomarker of myocardial injury". Clinical Chemistry. 55 (11): 1944–9. doi:10.1373/clinchem.2009.125310. PMID 19696117.
Further reading
- Kukreja, RC; Yin, C; Salloum, FN (2011-07-07). "MicroRNA – New Players in Cardiac Injury and Protection". Molecular Pharmacology. 80 (4): 558–64. doi:10.1124/mol.111.073528. PMC 3187527. PMID 21737570.