miR-134
| miR-134 | |
|---|---|
| File:Mir-134 SS.png Conserved secondary structure of miR-134 | |
| Identifiers | |
| Symbol | mir-134 |
| Alt. Symbols | MIR134 |
| Rfam | RF00699 |
| miRBase | MI0000474 |
| miRBase family | MIPF0000112 |
| Entrez | 406924 |
| HUGO | 31519 |
| Other data | |
| Domain(s) | Mammalia |
| GO | 0035195 |
| SO | 0001244 |
| Locus | Chr. 14 [1] |
| PDB structures | PDBe |
miR-134 is a family of microRNA precursors found in mammals, including humans.[1] MicroRNAs are typically transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product.[2] The excised region or, mature product, of the miR-134 precursor is the microRNA mir-134.
miR-134 was one of a number of microRNAs found to be increasingly expressed in schizophrenia.[3]
Functions
miR-134 is a brain-specific microRNA; in rats it is localised specifically in hippocampal neurons and may indirectly regulate synaptic development through antisense pairing with LIMK1 mRNA.[4][5] In the human brain, SIRT1 is thought to mediate CREB protein through miR-134, giving the microRNA a role in higher brain functions such a memory formation.[6]
miR-134 has also been reported to function in mouse embryonic stem cells as part of a complex network regulating their differentiation.[7]
Applications
miR-134 levels in circulating blood could potentially be used as a peripheral biomarker for bipolar disorder.[8]
References
- ↑ Landgraf, P; Rusu, M; Sheridan, R; Sewer, A; Iovino, N; Aravin, A; Pfeffer, S; Rice, A; et al. (Jun 29, 2007). "A mammalian microRNA expression atlas based on small RNA library sequencing". Cell. 129 (7): 1401–14. doi:10.1016/j.cell.2007.04.040. PMC 2681231. PMID 17604727.
- ↑ Ambros, V (2001). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823&ndash, 826. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
- ↑ Santarelli, DM; Beveridge, NJ; Tooney, PA; Cairns, MJ (Jan 15, 2011). "Upregulation of dicer and microRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia". Biological Psychiatry. 69 (2): 180–7. doi:10.1016/j.biopsych.2010.09.030. PMID 21111402.
- ↑ Schratt, GM; Tuebing, F; Nigh, EA; Kane, CG; Sabatini, ME; Kiebler, M; Greenberg, ME (Jan 19, 2006). "A brain-specific microRNA regulates dendritic spine development". Nature. 439 (7074): 283–9. doi:10.1038/nature04367. PMID 16421561.
- ↑ Tai, HC; Schuman, EM (Feb 21, 2006). "MicroRNA: microRNAs reach out into dendrites". Current Biology. 16 (4): R121–3. doi:10.1016/j.cub.2006.02.006. PMID 16488859.
- ↑ Gao, J; Wang, WY; Mao, YW; Gräff, J; Guan, JS; Pan, L; Mak, G; Kim, D; Su, SC; Tsai, LH (Aug 26, 2010). "A novel pathway regulates memory and plasticity via SIRT1 and miR-134". Nature. 466 (7310): 1105–9. doi:10.1038/nature09271. PMC 2928875. PMID 20622856.
- ↑ Tay, YM; Tam, WL; Ang, YS; Gaughwin, PM; Yang, H; Wang, W; Liu, R; George, J; Ng, HH; Perera, RJ; Lufkin, T; Rigoutsos, I; Thomson, AM; Lim, B (Jan 2008). "MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1". Stem Cells. 26 (1): 17–29. doi:10.1634/stemcells.2007-0295. PMID 17916804.
- ↑ Rong, H; Liu, TB; Yang, KJ; Yang, HC; Wu, DH; Liao, CP; Hong, F; Yang, HZ; Wan, F; Ye, XY; Xu, D; Zhang, X; Chao, CA; Shen, QJ (Jan 2011). "MicroRNA-134 plasma levels before and after treatment for bipolar mania". Journal of Psychiatric Research. 45 (1): 92–5. doi:10.1016/j.jpsychires.2010.04.028. PMID 20546789.
External links