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*{{cite journal | author=Murphy C |title=Dual function of rhoD in vesicular movement and cell motility |journal=Eur. J. Cell Biol. |volume=80 |issue= 6 |pages= 391–8 |year= 2001 |pmid= 11484930 |doi=10.1078/0171-9335-00173 |name-list-format=vanc| author2=Saffrich R | author3=Olivo-Marin JC | display-authors=3 | last4=Giner | first4=A | last5=Ansorge | first5=W | last6=Fotsis | first6=T | last7=Zerial | first7=M }} | *{{cite journal | author=Murphy C |title=Dual function of rhoD in vesicular movement and cell motility |journal=Eur. J. Cell Biol. |volume=80 |issue= 6 |pages= 391–8 |year= 2001 |pmid= 11484930 |doi=10.1078/0171-9335-00173 |name-list-format=vanc| author2=Saffrich R | author3=Olivo-Marin JC | display-authors=3 | last4=Giner | first4=A | last5=Ansorge | first5=W | last6=Fotsis | first6=T | last7=Zerial | first7=M }} | ||
*{{cite journal |vauthors=Zanata SM, Hovatta I, Rohm B, Püschel AW |title=Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse |journal=J. Neurosci. |volume=22 |issue= 2 |pages= 471–7 |year= 2002 |pmid= 11784792 |doi= }} | *{{cite journal |vauthors=Zanata SM, Hovatta I, Rohm B, Püschel AW |title=Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse |journal=J. Neurosci. |volume=22 |issue= 2 |pages= 471–7 |year= 2002 |pmid= 11784792 |doi= }} | ||
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M}} | ||
*{{cite journal |vauthors=Gasman S, Kalaidzidis Y, Zerial M |title=RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase |journal=Nat. Cell Biol. |volume=5 |issue= 3 |pages= 195–204 |year= 2003 |pmid= 12577064 |doi= 10.1038/ncb935 }} | *{{cite journal |vauthors=Gasman S, Kalaidzidis Y, Zerial M |title=RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase |journal=Nat. Cell Biol. |volume=5 |issue= 3 |pages= 195–204 |year= 2003 |pmid= 12577064 |doi= 10.1038/ncb935 }} | ||
*{{cite journal |vauthors=Jaffe AB, Aspenström P, Hall A |title=Human CNK1 Acts as a Scaffold Protein, Linking Rho and Ras Signal Transduction Pathways |journal=Mol. Cell. Biol. |volume=24 |issue= 4 |pages= 1736–46 |year= 2004 |pmid= 14749388 |doi=10.1128/MCB.24.4.1736-1746.2004 | pmc=344169 }} | *{{cite journal |vauthors=Jaffe AB, Aspenström P, Hall A |title=Human CNK1 Acts as a Scaffold Protein, Linking Rho and Ras Signal Transduction Pathways |journal=Mol. Cell. Biol. |volume=24 |issue= 4 |pages= 1736–46 |year= 2004 |pmid= 14749388 |doi=10.1128/MCB.24.4.1736-1746.2004 | pmc=344169 }} | ||
*{{cite journal | author=Flaxenburg JA |title=The CD40-induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and phosphatidylinositol 3-kinase |journal=J. Immunol. |volume=172 |issue= 12 |pages= 7503–9 |year= 2004 |pmid= 15187129 |doi= 10.4049/jimmunol.172.12.7503|name-list-format=vanc| author2=Melter M | author3=Lapchak PH | display-authors=3 | last4=Briscoe | first4=DM | last5=Pal | first5=S }} | *{{cite journal | author=Flaxenburg JA |title=The CD40-induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and phosphatidylinositol 3-kinase |journal=J. Immunol. |volume=172 |issue= 12 |pages= 7503–9 |year= 2004 |pmid= 15187129 |doi= 10.4049/jimmunol.172.12.7503|name-list-format=vanc| author2=Melter M | author3=Lapchak PH | display-authors=3 | last4=Briscoe | first4=DM | last5=Pal | first5=S }} | ||
*{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }} | *{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }} | ||
*{{cite journal | author=Barrios-Rodiles M |title=High-throughput mapping of a dynamic signaling network in mammalian cells |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 |name-list-format=vanc| author2=Brown KR | author3=Ozdamar B | display-authors=3 | last4=Bose | first4=R | last5=Liu | first5=Z | last6=Donovan | first6=RS | last7=Shinjo | first7=F | last8=Liu | first8=Y | last9=Dembowy | first9=J }} | *{{cite journal | author=Barrios-Rodiles M |title=High-throughput mapping of a dynamic signaling network in mammalian cells |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 |name-list-format=vanc| author2=Brown KR | author3=Ozdamar B | display-authors=3 | last4=Bose | first4=R | last5=Liu | first5=Z | last6=Donovan | first6=RS | last7=Shinjo | first7=F | last8=Liu | first8=Y | last9=Dembowy | first9=J |bibcode=2005Sci...307.1621B}} | ||
*{{cite journal | author=Birukova AA |title=Differential Regulation of Pulmonary Endothelial Monolayer Integrity by Varying Degrees of Cyclic Stretch |journal=Am. J. Pathol. |volume=168 |issue= 5 |pages= 1749–61 |year= 2006 |pmid= 16651639 |doi=10.2353/ajpath.2006.050431 | pmc=1606576 |name-list-format=vanc| author2=Chatchavalvanich S | author3=Rios A | display-authors=3 | last4=Kawkitinarong | first4=Kamon | last5=Garcia | first5=Joe G.N. | last6=Birukov | first6=Konstantin G. }} | *{{cite journal | author=Birukova AA |title=Differential Regulation of Pulmonary Endothelial Monolayer Integrity by Varying Degrees of Cyclic Stretch |journal=Am. J. Pathol. |volume=168 |issue= 5 |pages= 1749–61 |year= 2006 |pmid= 16651639 |doi=10.2353/ajpath.2006.050431 | pmc=1606576 |name-list-format=vanc| author2=Chatchavalvanich S | author3=Rios A | display-authors=3 | last4=Kawkitinarong | first4=Kamon | last5=Garcia | first5=Joe G.N. | last6=Birukov | first6=Konstantin G. }} | ||
*{{cite journal |vauthors=Ito Y, Kanamaru A, Tada A |title=A novel agent, methylophiopogonanone B, promotes Rho activation and tubulin depolymerization |journal=Mol. Cell. Biochem. |volume=297 |issue= 1–2 |pages= 121–9 |year= 2007 |pmid= 17029007 |doi= 10.1007/s11010-006-9336-y }} | *{{cite journal |vauthors=Ito Y, Kanamaru A, Tada A |title=A novel agent, methylophiopogonanone B, promotes Rho activation and tubulin depolymerization |journal=Mol. Cell. Biochem. |volume=297 |issue= 1–2 |pages= 121–9 |year= 2007 |pmid= 17029007 |doi= 10.1007/s11010-006-9336-y }} |
Latest revision as of 03:16, 26 June 2018
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
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UniProt |
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Location (UCSC) | n/a | n/a | |||||
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Wikidata | |||||||
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RhoD (Ras homolog gene family, member D) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.[1] It is encoded by the gene RHOD.[2]
It binds GTP and is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton.[2]
Interactions
RhoD has been shown to interact with CNKSR1[3] and DIAPH2.[4]
References
- ↑ Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol. 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. ISSN 0962-8924. PMID 16949823.
- ↑ 2.0 2.1 "Entrez Gene: RHOD ras homolog gene family, member D".
- ↑ Jaffe, Aron B; Aspenström Pontus; Hall Alan (Feb 2004). "Human CNK1 Acts as a Scaffold Protein, Linking Rho and Ras Signal Transduction Pathways". Mol. Cell. Biol. United States. 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. ISSN 0270-7306. PMC 344169. PMID 14749388.
- ↑ Gasman, Stéphane; Kalaidzidis Yannis; Zerial Marino (Mar 2003). "RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase". Nat. Cell Biol. England. 5 (3): 195–204. doi:10.1038/ncb935. ISSN 1465-7392. PMID 12577064.
Further reading
- Ridley AJ (2001). "Rho proteins: linking signaling with membrane trafficking". Traffic. 2 (5): 303–10. doi:10.1034/j.1600-0854.2001.002005303.x. PMID 11350626.
- Shimizu F, Watanabe TK, Okuno S, et al. (1997). "Isolation of a novel human cDNA (rhoHP1) homologous to rho genes". Biochim. Biophys. Acta. 1351 (1–2): 13–6. doi:10.1016/s0167-4781(97)00008-0. PMID 9116026.
- Kim HS, Choi JY, Jung AR, et al. (2000). "Assignment of the human RhoHP1 gene (ARHD) to chromosome 11q14.3 by radiation hybrid mapping". Cytogenet. Cell Genet. 89 (1–2): 53. doi:10.1159/000015562. PMID 10894936.
- Murphy C, Saffrich R, Olivo-Marin JC, et al. (2001). "Dual function of rhoD in vesicular movement and cell motility". Eur. J. Cell Biol. 80 (6): 391–8. doi:10.1078/0171-9335-00173. PMID 11484930.
- Zanata SM, Hovatta I, Rohm B, Püschel AW (2002). "Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse". J. Neurosci. 22 (2): 471–7. PMID 11784792.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gasman S, Kalaidzidis Y, Zerial M (2003). "RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase". Nat. Cell Biol. 5 (3): 195–204. doi:10.1038/ncb935. PMID 12577064.
- Jaffe AB, Aspenström P, Hall A (2004). "Human CNK1 Acts as a Scaffold Protein, Linking Rho and Ras Signal Transduction Pathways". Mol. Cell. Biol. 24 (4): 1736–46. doi:10.1128/MCB.24.4.1736-1746.2004. PMC 344169. PMID 14749388.
- Flaxenburg JA, Melter M, Lapchak PH, et al. (2004). "The CD40-induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and phosphatidylinositol 3-kinase". J. Immunol. 172 (12): 7503–9. doi:10.4049/jimmunol.172.12.7503. PMID 15187129.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153.
- Birukova AA, Chatchavalvanich S, Rios A, et al. (2006). "Differential Regulation of Pulmonary Endothelial Monolayer Integrity by Varying Degrees of Cyclic Stretch". Am. J. Pathol. 168 (5): 1749–61. doi:10.2353/ajpath.2006.050431. PMC 1606576. PMID 16651639.
- Ito Y, Kanamaru A, Tada A (2007). "A novel agent, methylophiopogonanone B, promotes Rho activation and tubulin depolymerization". Mol. Cell. Biochem. 297 (1–2): 121–9. doi:10.1007/s11010-006-9336-y. PMID 17029007.
- Tan W, Martin D, Gutkind JS (2007). "The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4". J. Biol. Chem. 281 (51): 39542–9. doi:10.1074/jbc.M609062200. PMID 17056591.
- Lakshman N, Kim A, Bayless KJ, et al. (2007). "Rho plays a central role in regulating local cell-matrix mechanical interactions in 3D culture". Cell Motil. Cytoskeleton. 64 (6): 434–45. doi:10.1002/cm.20194. PMID 17342762.
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