POEMS syndrome diagnostic criteria: Difference between revisions
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== Overview == | == Overview == | ||
According to the The International Myeloma Working Group, the diagnosis of POEMS syndrome may be established if both mandatory criteria, one major and one minor criteria are fulfilled. Mandatory criteria include presence of polyneuropathy and a monoclonal plasma | According to the The International Myeloma Working Group, the diagnosis of POEMS syndrome may be established if both mandatory criteria, one major and one minor criteria are fulfilled. Mandatory criteria include presence of [[polyneuropathy]] and a [[Monoclonal antibody|monoclonal]] [[plasma cell]] proliferative disorder. Major criteria include presence of sclerotic [[bone]] lesions or mixed sclerotic/lytic lesions, presence of [[Castleman's disease]] and elevated [[serum]] [[VEGF]] levels. Minor criteria include presence of [[organomegaly]], extravascular volume overload, [[endocrinopathy]], [[skin]] changes, [[papilledema]], [[thrombocytosis]] and [[polycythemia]]. | ||
==Diagnostic Criteria== | ==Diagnostic Criteria== | ||
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* [[Polyneuropathy]] | * [[Polyneuropathy]] | ||
* A monoclonal plasma | * A [[Monoclonal gammopathy|monoclonal]] [[plasma cell]] proliferative disorder | ||
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* Sclerotic bone lesions or mixed sclerotic/lytic lesions | * Sclerotic [[bone]] lesions or mixed sclerotic/lytic lesions | ||
* [[Castleman's disease]] | * [[Castleman's disease]] | ||
* Elevated [[VEGF]] levels | * Elevated [[VEGF]] levels | ||
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* Organomegaly (splenomegaly, hepatomegaly or lymphadenopathy) | * [[Organomegaly]] ([[splenomegaly]], [[hepatomegaly]] or [[lymphadenopathy]]) | ||
* Extra-vascular volume overload (peripheral edema, ascites, pleural effusion) | * Extra-vascular volume overload ([[peripheral edema]], [[ascites]], [[pleural effusion]]) | ||
* Endocrinopathy: | * [[Endocrinopathy]]: | ||
** Adrenal | ** [[Adrenal gland|Adrenal]] | ||
** Thyroid | ** [[Thyroid]] | ||
** Pituitary | ** [[Pituitary]] | ||
** Gonadal | ** [[Gonadal]] | ||
** Parathyroid | ** [[Parathyroid gland|Parathyroid]] | ||
** Pancreatic disorders excluding diabetes mellitus and hypothyroidism | ** [[Pancreatic]] disorders excluding [[diabetes mellitus]] and [[hypothyroidism]] | ||
* Skin changes: | * [[Skin]] changes: | ||
** Hyperpigmentation | ** [[Hyperpigmentation]] | ||
** | ** [[Hypertrichosis]] | ||
** Glomeruloid hemangiomata | ** [[Angioma|Glomeruloid hemangiomata]] | ||
** | ** [[Plethora]] | ||
** Acrocyanosis | ** [[Acrocyanosis]] | ||
** Flushing | ** [[Flushing]] | ||
** Leukonychia | ** [[Leukonychia]] | ||
* Papilledema | * [[Papilledema]] | ||
* Thrombocytosis | * [[Thrombocytosis]] | ||
* Polycythemia | * [[Polycythemia]] | ||
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Latest revision as of 01:28, 6 February 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Syed Hassan A. Kazmi BSc, MD [2]
Overview
According to the The International Myeloma Working Group, the diagnosis of POEMS syndrome may be established if both mandatory criteria, one major and one minor criteria are fulfilled. Mandatory criteria include presence of polyneuropathy and a monoclonal plasma cell proliferative disorder. Major criteria include presence of sclerotic bone lesions or mixed sclerotic/lytic lesions, presence of Castleman's disease and elevated serum VEGF levels. Minor criteria include presence of organomegaly, extravascular volume overload, endocrinopathy, skin changes, papilledema, thrombocytosis and polycythemia.
Diagnostic Criteria
According to the The International Myeloma Working Group, the diagnosis of POEMS syndrome may be established if both mandatory criteria, at least one major and at least one minor criteria are fulfilled. The following table enlists the mandatory, major and minor criteria required for the diagnosis of POEMS syndrome:[1]
| Mandatory Criteria | Major Criteria | Minor Criteria |
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