Subdural hematoma pathophysiology: Difference between revisions

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* These vein s will drain venous blood from underlying brain tissue to the dural sinuses.
* These vein s will drain venous blood from underlying brain tissue to the dural sinuses.
* Rupture of these bridging vein (mostly due to head trauma) will result in hemorrhage between dura matter and arachnoid, and leads to subdural hematoma.
* Rupture of these bridging vein (mostly due to head trauma) will result in hemorrhage between dura matter and arachnoid, and leads to subdural hematoma.
[[File:PMC3099599 wjem12 2p0144f2b.png|500px|none|thumb|Bridging vein [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099599/ Source:Image Courtesy by Steven C. Gabaeff, MD]]]


=== Pathogenesis ===
=== Pathogenesis ===
* The exact pathogenesis of [disease name] is not completely understood.
* It is understood that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3]
OR
* It is understood that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
* [Pathogen name] is usually transmitted via the [transmission route] route to the human host.
* Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
* [Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
* The progression to [disease name] usually involves the [molecular pathway].
* The pathophysiology of [disease/malignancy] depends on the histological subtype.


[[File:Types of Hematoma.jpg|500px|none|thumb|Types of Hematoma|https://commons.wikimedia.org/wiki/File:Types_of_Hematoma.jpg]]
[[File:Types of Hematoma.jpg|500px|none|thumb|Types of Hematoma|https://commons.wikimedia.org/wiki/File:Types_of_Hematoma.jpg]]

Revision as of 14:11, 29 May 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Pathophysiology

Physiology

The normal physiology of bridging veins can be understood as follows:[1]

  • In embryonic period, there is lots of anastomosis between brain and dura matter venous drainage.
  • After 12 weeks of gestation these anastomosis will disappear and what is left from them create bridging veins.
  • These vein s will drain venous blood from underlying brain tissue to the dural sinuses.
  • Rupture of these bridging vein (mostly due to head trauma) will result in hemorrhage between dura matter and arachnoid, and leads to subdural hematoma.
Bridging vein Source:Image Courtesy by Steven C. Gabaeff, MD


Pathogenesis

  • It is understood that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3]
https://commons.wikimedia.org/wiki/File:Types_of_Hematoma.jpg

Genetics

[Disease name] is transmitted in [mode of genetic transmission] pattern.

OR

Genes involved in the pathogenesis of [disease name] include:

  • [Gene1]
  • [Gene2]
  • [Gene3]

OR

The development of [disease name] is the result of multiple genetic mutations such as:

  • [Mutation 1]
  • [Mutation 2]
  • [Mutation 3]

Associated Conditions

Conditions associated with [disease name] include:

  • [Condition 1]
  • [Condition 2]
  • [Condition 3]

Gross Pathology

On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].

Microscopic Pathology

On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].


References

  1. Famaey, Nele; Ying Cui, Zhao; Umuhire Musigazi, Grace; Ivens, Jan; Depreitere, Bart; Verbeken, Erik; Vander Sloten, Jos (2015). "Structural and mechanical characterisation of bridging veins: A review". Journal of the Mechanical Behavior of Biomedical Materials. 41: 222–240. doi:10.1016/j.jmbbm.2014.06.009. ISSN 1751-6161.

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