VIPoma other diagnostic studies: Difference between revisions
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==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
*Immunohistochemical staining may be helpful in the diagnosis of VIPoma. Findings suggestive of VIPoma include positive histochemical staining for: | *Immunohistochemical staining may be helpful in the diagnosis of VIPoma. Findings suggestive of VIPoma include positive histochemical staining for:<ref name="pmid18684027">{{cite journal| author=Chetty R| title=An overview of practical issues in the diagnosis of gastroenteropancreatic neuroendocrine pathology. | journal=Arch Pathol Lab Med | year= 2008 | volume= 132 | issue= 8 | pages= 1285-9 | pmid=18684027 | doi=10.1043/1543-2165(2008)132[1285:AOOPII]2.0.CO;2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18684027 }}</ref> | ||
**[[Chromogranin A]] | **[[Chromogranin A]] | ||
**[[Cytokeratin|Cytokeratin 19]] positive stain is an independent marker of aggressive behavior in pancreatic [[neuroendocrine tumors]]. | **[[Cytokeratin|Cytokeratin 19]] positive stain is an independent marker of aggressive behavior in pancreatic [[neuroendocrine tumors]]. | ||
**[[Synaptophysin]] | **[[Synaptophysin]] | ||
**[[Ki-67]] (indicates the percentage of [[Neoplasia|neoplastic cells]] immunolabeled for the marker of proliferation Ki67) | **[[Ki-67]] (indicates the percentage of [[Neoplasia|neoplastic cells]] immunolabeled for the marker of proliferation Ki67) | ||
Revision as of 15:20, 3 October 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Madhu Sigdel M.B.B.S.[2] Homa Najafi, M.D.[3]
Overview
Other diagnostic studies for VIPoma include immunohistochemical staining test, which demonstrates staining for markers such as chromogranin A, cytokeratin 19, synaptophysin, Ki-67, neuron specific enolase, PGP 9.5.
Other Diagnostic Studies
- Immunohistochemical staining may be helpful in the diagnosis of VIPoma. Findings suggestive of VIPoma include positive histochemical staining for:[1]
- Chromogranin A
- Cytokeratin 19 positive stain is an independent marker of aggressive behavior in pancreatic neuroendocrine tumors.
- Synaptophysin
- Ki-67 (indicates the percentage of neoplastic cells immunolabeled for the marker of proliferation Ki67)
- NSE (neuron-specific enolase)
- PGP 9.5 (protein gene product 9.5)
References
- ↑ Chetty R (2008). "An overview of practical issues in the diagnosis of gastroenteropancreatic neuroendocrine pathology". Arch Pathol Lab Med. 132 (8): 1285–9. doi:10.1043/1543-2165(2008)132[1285:AOOPII]2.0.CO;2. PMID 18684027.