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==Overview==
==Overview==
The [[patient]]s have a wide spectrum of clinical picture ranging from asymptomatic to [[anemia]], [[thrombocytopenia]], [[fever]], [[altered mental status]] and impaired [[renal]] function<ref name="pmid25119611">{{cite journal| author=George JN, Nester CM| title=Syndromes of thrombotic microangiopathy. | journal=N Engl J Med | year= 2014 | volume= 371 | issue= 7 | pages= 654-66 | pmid=25119611 | doi=10.1056/NEJMra1312353 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25119611  }} </ref>. Some [[patient]]s may also present with [[abdominal]] or [[cardiac]] symptoms<ref name="pmid28447417">{{cite journal| author=Kottke-Marchant K| title=Diagnostic approach to microangiopathic hemolytic disorders. | journal=Int J Lab Hematol | year= 2017 | volume= 39 Suppl 1 | issue=  | pages= 69-75 | pmid=28447417 | doi=10.1111/ijlh.12671 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28447417  }} </ref>.
The [[patient]]s have a wide spectrum of clinical picture ranging from asymptomatic to [[anemia]], [[thrombocytopenia]], [[fever]], [[altered mental status]] and impaired [[renal]] function<ref name="pmid25119611">{{cite journal| author=George JN, Nester CM| title=Syndromes of thrombotic microangiopathy. | journal=N Engl J Med | year= 2014 | volume= 371 | issue= 7 | pages= 654-66 | pmid=25119611 | doi=10.1056/NEJMra1312353 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25119611  }} </ref>. Some [[patient]]s may also present with [[abdominal]] or [[cardiac]] symptoms<ref name="pmid28447417">{{cite journal| author=Kottke-Marchant K| title=Diagnostic approach to microangiopathic hemolytic disorders. | journal=Int J Lab Hematol | year= 2017 | volume= 39 Suppl 1 | issue=  | pages= 69-75 | pmid=28447417 | doi=10.1111/ijlh.12671 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28447417  }} </ref>.
==History and Symptoms==
===Common Symptoms===
Common symptoms of [[microangiopathic hemolytic anemia]] include<ref name="pmid28447417">{{cite journal| author=Kottke-Marchant K| title=Diagnostic approach to microangiopathic hemolytic disorders. | journal=Int J Lab Hematol | year= 2017 | volume= 39 Suppl 1 | issue=  | pages= 69-75 | pmid=28447417 | doi=10.1111/ijlh.12671 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28447417  }} </ref><ref name="pmid32595044">{{cite journal| author=| title=Correction to Lancet Infectious Diseases 2020; published online April 29. https://doi.org/10.1016/ S1473-3099(20)30064-5. | journal=Lancet Infect Dis | year= 2020 | volume= 20 | issue= 7 | pages= e148 | pmid=32595044 | doi=10.1016/S1473-3099(20)30370-4 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=32595044  }} </ref>:
* [[Pallor]]
* Yellowing of [[sclera]] and [[skin]]
* Dark colored urine due to raised level of [[urobilinogen]] and  unconjugated [[bilirubin]]
* [[Breathlessness]]
* Easy [[fatigability]]
* [[Petechia]]
* [[Purpura]]
* [[Epistaxis]]
* [[Bleeding]] from [[mucous membrane]]s
* [[Fever]]
* [[Altered mental status]]
* [[Seizures]]
* [[Stroke]]
* [[Dizziness]]
* [[Slurred speech]]
* [[Transient ischemic attacks]]
* [[Renal failure]]
* [[Oliguria]]
===Less Common Symptoms===
[[Abdominal pain]]
[[Nausea]]
[[Vomitting]]
[[Hematuria]]
[[Hypertension]]
[[Generalized Edema]]
[[Cardiac]] [[arrhythmia]]




Revision as of 18:36, 21 January 2021

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Mydah Sajid, MD[1]

Overview

The patients have a wide spectrum of clinical picture ranging from asymptomatic to anemia, thrombocytopenia, fever, altered mental status and impaired renal function[1]. Some patients may also present with abdominal or cardiac symptoms[2].

History and Symptoms

Common Symptoms

Common symptoms of microangiopathic hemolytic anemia include[2][3]:

Less Common Symptoms

Abdominal pain Nausea Vomitting Hematuria Hypertension Generalized Edema Cardiac arrhythmia



References

  1. ↑ George JN, Nester CM (2014). "Syndromes of thrombotic microangiopathy". N Engl J Med. 371 (7): 654–66. doi:10.1056/NEJMra1312353. PMID 25119611.
  2. ↑ 2.0 2.1 Kottke-Marchant K (2017). "Diagnostic approach to microangiopathic hemolytic disorders". Int J Lab Hematol. 39 Suppl 1: 69–75. doi:10.1111/ijlh.12671. PMID 28447417.
  3. ↑ "Correction to Lancet Infectious Diseases 2020; published online April 29. https://doi.org/10.1016/ S1473-3099(20)30064-5". Lancet Infect Dis. 20 (7): e148. 2020. doi:10.1016/S1473-3099(20)30370-4. PMID 32595044 Check |pmid= value (help). External link in |title= (help)

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