Fever of unknown origin laboratory findings: Difference between revisions
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*[[Complete blood count|Complete blood count with differential]] | *[[Complete blood count|Complete blood count with differential]] | ||
*[[Hemoglobin]] | *[[Hemoglobin]] | ||
*[[Basic metabolic panel]] | *[[Basic metabolic panel]] | ||
*[[Liver function test]] including aminotransferases ([[AST]] and [[ALT]]), [[LDH]], [[bilirubin]], and [[alkaline phosphatase]] | *[[Liver function test]] including aminotransferases ([[AST]] and [[ALT]]), [[LDH]], [[bilirubin]], and [[alkaline phosphatase]] | ||
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*[[Serum protein electrophoresis]] | *[[Serum protein electrophoresis]] | ||
*[[Tuberculin skin test]] | *[[Tuberculin skin test]] | ||
Other Laboratory work up done in case FUO other than mandatory work up are :<ref>{{Cite journal| issn = 1058-4838| volume = 24| issue = 3| pages = 291–300; quiz 301-302| last = Hirschmann| first = J. V.| title = Fever of unknown origin in adults| journal = Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America| date = 1997-03| pmid = 9114175}}</ref><ref>{{Cite journal| doi = 10.1016/j.idc.2007.09.004| issn = 0891-5520| volume = 21| issue = 4| pages = 1137–1187, xi| last = Cunha| first = Burke A.| title = Fever of unknown origin: focused diagnostic approach based on clinical clues from the history, physical examination, and laboratory tests| journal = Infectious Disease Clinics of North America| date = 2007-12| pmid = 18061092}}</ref> | Other Laboratory work up done in case FUO other than mandatory work up are :<ref>{{Cite journal| issn = 1058-4838| volume = 24| issue = 3| pages = 291–300; quiz 301-302| last = Hirschmann| first = J. V.| title = Fever of unknown origin in adults| journal = Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America| date = 1997-03| pmid = 9114175}}</ref><ref>{{Cite journal| doi = 10.1016/j.idc.2007.09.004| issn = 0891-5520| volume = 21| issue = 4| pages = 1137–1187, xi| last = Cunha| first = Burke A.| title = Fever of unknown origin: focused diagnostic approach based on clinical clues from the history, physical examination, and laboratory tests| journal = Infectious Disease Clinics of North America| date = 2007-12| pmid = 18061092}}</ref> | ||
* HIV serology | *HIV serology | ||
* [[Coombs test (patient information)|Coombs test]] | *[[Coombs test (patient information)|Coombs test]] | ||
* [[Cold agglutinins]] | *[[Cold agglutinins]] | ||
* [[Heterophile antibody test]] | *[[Heterophile antibody test]] | ||
* [[Thyroid peroxidase]] and [[anti thyroid antibody test | *[[Thyroid peroxidase]] and [[anti thyroid antibody test]] | ||
==References== | ==References== | ||
Revision as of 12:58, 25 January 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: febris continua e causa ignota; febris e causa ignota; febris E.C.I.; fever/pyrexia of obscured/undetermined/uncertain/unidentifiable/unknown focus/origin/source; fever/pyrexia without a focus/origin/source; FUO; PUO
Laboratory Workup of Fever of Unknown Origin
Laboratory work up for FUO is directed by history and physical examination which may provide some clues helping in narrowing down investigations. However some laboratory investigations listed below are mandatory in cases of FUO.[1]
- Complete blood count with differential
- Hemoglobin
- Basic metabolic panel
- Liver function test including aminotransferases (AST and ALT), LDH, bilirubin, and alkaline phosphatase
- Creatine kinase
- Blood cultures (at least 2 sets)
- Urinalysis with microscopic examination
- Urine cultures
- Erythrocyte sedimentation rate
- C-reactive protein
- Gamma-glutamyl transferase
- Antinuclear antibodies
- Rheumatoid factor
- Serum protein electrophoresis
- Tuberculin skin test
Other Laboratory work up done in case FUO other than mandatory work up are :[2][3]
- HIV serology
- Coombs test
- Cold agglutinins
- Heterophile antibody test
- Thyroid peroxidase and anti thyroid antibody test
References
- ↑ Mulders-Manders CM, Simon A, Bleeker-Rovers CP (2016). "Rheumatologic diseases as the cause of fever of unknown origin". Best Pract Res Clin Rheumatol. 30 (5): 789–801. doi:10.1016/j.berh.2016.10.005. PMID 27964789.
- ↑ Hirschmann, J. V. (1997-03). "Fever of unknown origin in adults". Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America. 24 (3): 291–300, quiz 301-302. ISSN 1058-4838. PMID 9114175. Check date values in:
|date=(help) - ↑ Cunha, Burke A. (2007-12). "Fever of unknown origin: focused diagnostic approach based on clinical clues from the history, physical examination, and laboratory tests". Infectious Disease Clinics of North America. 21 (4): 1137–1187, xi. doi:10.1016/j.idc.2007.09.004. ISSN 0891-5520. PMID 18061092. Check date values in:
|date=(help)