Fever of unknown origin other diagnostic studies: Difference between revisions
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==Overview== | ==Overview== | ||
Other than laboratory work up some other investigation listed below may be helpful in finding cause of FUO.<ref name=" | Other than laboratory work up some other investigation listed below may be helpful in finding cause of FUO.<ref name="pmid26031980">{{cite journal| author=Mulders-Manders C, Simon A, Bleeker-Rovers C| title=Fever of unknown origin. | journal=Clin Med (Lond) | year= 2015 | volume= 15 | issue= 3 | pages= 280-4 | pmid=26031980 | doi=10.7861/clinmedicine.15-3-280 | pmc=4953114 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26031980 }}</ref> | ||
==Imaging Studies== | ==Imaging Studies== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: febris continua e causa ignota; febris e causa ignota; febris E.C.I.; fever/pyrexia of obscured/undetermined/uncertain/unidentifiable/unknown focus/origin/source; fever/pyrexia without a focus/origin/source; FUO; PUO
Overview
Other than laboratory work up some other investigation listed below may be helpful in finding cause of FUO.[1]
Imaging Studies
Chest Radiograph
Chest radiograph should be considered as a part of the initial diagnostic workup.
Echocardiography
Echocardiography should be performed when suspecting endocarditis.[2]
Abdominal Ultrasonography
Hepatobiliary pathology may be detected by abdominal ultrasonography.
Chest CT Scan
CT scan of the chest may detect nodular lesions (suggestive of malignancy, fungal, mycobacterial, or nocardial infection) and mediastinal adenopathy (suggestive of lymphoma, histoplasmosis, or sarcoidosis).
Abdominal CT Scan
An abdominal CT scan may show intra-abdominal abscess or malignancy of the visceral organs.
Positron Emission Tomography
PET scan can be used it is helpful in less than 50 % of cases.
Other Diagnostic Studies
Lymph Node Biopsy
Lymph node biopsy may be useful when suspecting lymphoma, lymphogranuloma venereum, toxoplasmosis, and Kikuchi disease. Granulomas in lymph node biopsies may indicate a disorder associated with granulomatous inflammation (eg, tuberculosis, sarcoidosis) or lymphoma. The preferred lymph nodes to biopsy are the posterior cervical, epitrochlear, or supraclavicular nodes.
Bone Marrow Biopsy
Bone marrow biopsy may be considered when there are clues for hematologic malignancies.
Naproxen Test
Naproxen test can be used to distinguish neoplastic fever from other etiologies of FUO.
At a dosage of 375 mg twice daily, naproxen demonstrated no antipyretic activity against fever in patients with occult infection. Defervescence within 12 hours occurs in almost all patients with neoplastic fever. The naproxen test is considered positive when there is a rapid or sustained abatement of fever during the 3 days of the trial period. Fever recurs after discontinuation of naproxen in patients with neoplasms.[3]
References
- ↑ Mulders-Manders C, Simon A, Bleeker-Rovers C (2015). "Fever of unknown origin". Clin Med (Lond). 15 (3): 280–4. doi:10.7861/clinmedicine.15-3-280. PMC 4953114. PMID 26031980.
- ↑ McGregor AC, Moore DA (2015). "Infectious causes of fever of unknown origin". Clin Med (Lond). 15 (3): 285–7. doi:10.7861/clinmedicine.15-3-285. PMC 4953115. PMID 26031981.
- ↑ Chang, J. C. (1987-03). "How to differentiate neoplastic fever from infectious fever in patients with cancer: usefulness of the naproxen test". Heart & Lung: The Journal of Critical Care. 16 (2): 122–127. ISSN 0147-9563. PMID 3028981. Check date values in:
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