Microangiopathic hemolytic anemia medical therapy: Difference between revisions
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* Patients should be given [[folic acid|folic acid (oral]] as [[patient]]s can develop [[folate]] deficiency due to ongoing [[hemolysis]] <ref name="pmid22624596">{{cite journal| author=Scully M, Hunt BJ, Benjamin S, Liesner R, Rose P, Peyvandi F | display-authors=etal| title=Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies. | journal=Br J Haematol | year= 2012 | volume= 158 | issue= 3 | pages= 323-35 | pmid=22624596 | doi=10.1111/j.1365-2141.2012.09167.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22624596 }} </ref>. | * Patients should be given [[folic acid|folic acid (oral]] as [[patient]]s can develop [[folate]] deficiency due to ongoing [[hemolysis]] <ref name="pmid22624596">{{cite journal| author=Scully M, Hunt BJ, Benjamin S, Liesner R, Rose P, Peyvandi F | display-authors=etal| title=Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies. | journal=Br J Haematol | year= 2012 | volume= 158 | issue= 3 | pages= 323-35 | pmid=22624596 | doi=10.1111/j.1365-2141.2012.09167.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22624596 }} </ref>. | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 10:51, 30 January 2021
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Microangiopathic hemolytic anemia Microchapters |
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Differentiating Microangiopathic hemolytic anemia from other Diseases |
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Associate Editor(s)-in-Chief: Mydah Sajid, MD[1]
- Microangiopathic hemolytic anemia is a medical emergency and requires prompt treatment.
- Therapeutic plasmapheresis is the treatment of choice. It should be instituted immediately in patients with high clinical suspicion of microangiopathic hemolytic anemic before the results of confirmatory diagnostic tests like ADAM TS13 assay[1].
- If plasmapheresis is unavailable, patients can be administered large volume plasma or FFPs. This treatment is not as efficacious as plasmapheresis, but it can be suitable alternative[2] .
- Patients should be given folic acid (oral as patients can develop folate deficiency due to ongoing hemolysis [3].
References
- ↑ Arnold DM, Patriquin CJ, Nazy I (2017). "Thrombotic microangiopathies: a general approach to diagnosis and management". CMAJ. 189 (4): E153–E159. doi:10.1503/cmaj.160142. PMC 5266569. PMID 27754896.
- ↑ Rock GA, Shumak KH, Buskard NA, Blanchette VS, Kelton JG, Nair RC; et al. (1991). "Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. Canadian Apheresis Study Group". N Engl J Med. 325 (6): 393–7. doi:10.1056/NEJM199108083250604. PMID 2062330.
- ↑ Scully M, Hunt BJ, Benjamin S, Liesner R, Rose P, Peyvandi F; et al. (2012). "Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies". Br J Haematol. 158 (3): 323–35. doi:10.1111/j.1365-2141.2012.09167.x. PMID 22624596.