Acute megakaryoblastic leukemia future or investigational therapies: Difference between revisions
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'''Non-Down syndrome AMKL:''' | |||
* MLN8237 (alisertib)—is Aurora A Kinase (AURKA) inhibitor responsible for halting AMKL blast cells reproduction.<ref name="SchweitzerZimmermann2015">{{cite journal|last1=Schweitzer|first1=Jana|last2=Zimmermann|first2=Martin|last3=Rasche|first3=Mareike|last4=von Neuhoff|first4=Christine|last5=Creutzig|first5=Ursula|last6=Dworzak|first6=Michael|last7=Reinhardt|first7=Dirk|last8=Klusmann|first8=Jan-Henning|title=Improved outcome of pediatric patients with acute megakaryoblastic leukemia in the AML-BFM 04 trial|journal=Annals of Hematology|volume=94|issue=8|year=2015|pages=1327–1336|issn=0939-5555|doi=10.1007/s00277-015-2383-2}}</ref> | |||
* GANT61— a Hedgehog HH/GLI antagonist causes apoptosis of the AML cell lines by targeting ''the CBFA2T3''-''GLIS2 fusion gene (expressed in'' 17% of non-Down syndrome patients with AMKL).<ref name="MasettiBertuccio2017">{{cite journal|last1=Masetti|first1=Riccardo|last2=Bertuccio|first2=Salvatore Nicola|last3=Astolfi|first3=Annalisa|last4=Chiarini|first4=Francesca|last5=Lonetti|first5=Annalisa|last6=Indio|first6=Valentina|last7=De Luca|first7=Matilde|last8=Bandini|first8=Jessica|last9=Serravalle|first9=Salvatore|last10=Franzoni|first10=Monica|last11=Pigazzi|first11=Martina|last12=Martelli|first12=Alberto Maria|last13=Basso|first13=Giuseppe|last14=Locatelli|first14=Franco|last15=Pession|first15=Andrea|title=Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene|journal=Journal of Hematology & Oncology|volume=10|issue=1|year=2017|issn=1756-8722|doi=10.1186/s13045-017-0396-0}}</ref> | |||
'''Down syndrome and non-DS AMKL:''' | |||
* Tetrandrine— an alkaloid derivative of Chinese and Japanese herbs. It blocks calcium channels and also inhibit reactive oxygen species (ROS). Additionally, causes apoptosis of the cancerous cells.<ref name="LiuLiu2016">{{cite journal|last1=Liu|first1=Ting|last2=Liu|first2=Xin|last3=Li|first3=Wenhua|title=Tetrandrine, a Chinese plant-derived alkaloid, is a potential candidate for cancer chemotherapy|journal=Oncotarget|volume=7|issue=26|year=2016|pages=40800–40815|issn=1949-2553|doi=10.18632/oncotarget.8315}}</ref> | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 21:21, 17 April 2021
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Non-Down syndrome AMKL:
- MLN8237 (alisertib)—is Aurora A Kinase (AURKA) inhibitor responsible for halting AMKL blast cells reproduction.[1]
- GANT61— a Hedgehog HH/GLI antagonist causes apoptosis of the AML cell lines by targeting the CBFA2T3-GLIS2 fusion gene (expressed in 17% of non-Down syndrome patients with AMKL).[2]
Down syndrome and non-DS AMKL:
- Tetrandrine— an alkaloid derivative of Chinese and Japanese herbs. It blocks calcium channels and also inhibit reactive oxygen species (ROS). Additionally, causes apoptosis of the cancerous cells.[3]
References
- ↑ Schweitzer, Jana; Zimmermann, Martin; Rasche, Mareike; von Neuhoff, Christine; Creutzig, Ursula; Dworzak, Michael; Reinhardt, Dirk; Klusmann, Jan-Henning (2015). "Improved outcome of pediatric patients with acute megakaryoblastic leukemia in the AML-BFM 04 trial". Annals of Hematology. 94 (8): 1327–1336. doi:10.1007/s00277-015-2383-2. ISSN 0939-5555.
- ↑ Masetti, Riccardo; Bertuccio, Salvatore Nicola; Astolfi, Annalisa; Chiarini, Francesca; Lonetti, Annalisa; Indio, Valentina; De Luca, Matilde; Bandini, Jessica; Serravalle, Salvatore; Franzoni, Monica; Pigazzi, Martina; Martelli, Alberto Maria; Basso, Giuseppe; Locatelli, Franco; Pession, Andrea (2017). "Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene". Journal of Hematology & Oncology. 10 (1). doi:10.1186/s13045-017-0396-0. ISSN 1756-8722.
- ↑ Liu, Ting; Liu, Xin; Li, Wenhua (2016). "Tetrandrine, a Chinese plant-derived alkaloid, is a potential candidate for cancer chemotherapy". Oncotarget. 7 (26): 40800–40815. doi:10.18632/oncotarget.8315. ISSN 1949-2553.