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* Acute megakaryoblastic leukemia (AMKL) has a wide array of presentations. The onset is either acute or insidious. The degree of [[pancytopenia]] varies among patients.<ref name="pmid2978961">{{cite journal| author=Zipursky A, Peeters M, Poon A| title=Megakaryoblastic leukemia and Down's syndrome: a review. | journal=Pediatr Hematol Oncol | year= 1987 | volume= 4 | issue= 3 | pages= 211-30 | pmid=2978961 | doi=10.3109/08880018709141272 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2978961  }}</ref> Other features include [[fever]], irritability, [[headache]], fatigue, bone pain,<ref name="pmid12749007">{{cite journal| author=Paredes-Aguilera R, Romero-Guzman L, Lopez-Santiago N, Trejo RA| title=Biology, clinical, and hematologic features of acute megakaryoblastic leukemia in children. | journal=Am J Hematol | year= 2003 | volume= 73 | issue= 2 | pages= 71-80 | pmid=12749007 | doi=10.1002/ajh.10320 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12749007  }}</ref> [[hepatosplenomegaly]] (HSM), and [[lymphadenopathy]],<ref name="JayasudhaNair2014">{{cite journal|last1=Jayasudha|first1=A. V.|last2=Nair|first2=Rekha A.|last3=Jacob|first3=Priya Mary|last4=Renu|first4=S.|last5=Anila|first5=K. R.|last6=Sindhu Nair|first6=P.|last7=Priya Kumari|first7=T.|last8=Kusuma Kumary|first8=P.|title=Clinical and Hematological Profile of Acute Megakaryoblastic Leukemia: A 2 Year Study|journal=Indian Journal of Hematology and Blood Transfusion|volume=31|issue=2|year=2014|pages=169–173|issn=0971-4502|doi=10.1007/s12288-014-0413-1}}</ref><ref name="AthaleKaste2002">{{cite journal|last1=Athale|first1=Uma H.|last2=Kaste|first2=Sue C.|last3=Razzouk|first3=Bassem I.|last4=Rubnitz|first4=Jeffrey E.|last5=Ribeiro|first5=Raul C.|title=Skeletal Manifestations of Pediatric Acute Megakaryoblastic Leukemia|journal=Journal of Pediatric Hematology/Oncology|volume=24|issue=7|year=2002|pages=561–565|issn=1077-4114|doi=10.1097/00043426-200210000-00014}}</ref> pallor, generalized pain, temporal swelling, [[bruising]], and difficulty walking.<ref name="AthaleKaste20023">{{cite journal|last1=Athale|first1=Uma H.|last2=Kaste|first2=Sue C.|last3=Razzouk|first3=Bassem I.|last4=Rubnitz|first4=Jeffrey E.|last5=Ribeiro|first5=Raul C.|title=Skeletal Manifestations of Pediatric Acute Megakaryoblastic Leukemia|journal=Journal of Pediatric Hematology/Oncology|volume=24|issue=7|year=2002|pages=561–565|issn=1077-4114|doi=10.1097/00043426-200210000-00014}}</ref>
*[[Acute megakaryoblastic leukemia]] (AMKL) has a wide array of presentations. The onset is either acute or insidious. The degree of [[pancytopenia]] varies among patients.<ref name="pmid2978961">{{cite journal| author=Zipursky A, Peeters M, Poon A| title=Megakaryoblastic leukemia and Down's syndrome: a review. | journal=Pediatr Hematol Oncol | year= 1987 | volume= 4 | issue= 3 | pages= 211-30 | pmid=2978961 | doi=10.3109/08880018709141272 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2978961  }}</ref> Other features include [[fever]], irritability, [[headache]], fatigue, bone pain,<ref name="pmid12749007">{{cite journal| author=Paredes-Aguilera R, Romero-Guzman L, Lopez-Santiago N, Trejo RA| title=Biology, clinical, and hematologic features of acute megakaryoblastic leukemia in children. | journal=Am J Hematol | year= 2003 | volume= 73 | issue= 2 | pages= 71-80 | pmid=12749007 | doi=10.1002/ajh.10320 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12749007  }}</ref> [[hepatosplenomegaly]] (HSM), and [[lymphadenopathy]],<ref name="JayasudhaNair2014">{{cite journal|last1=Jayasudha|first1=A. V.|last2=Nair|first2=Rekha A.|last3=Jacob|first3=Priya Mary|last4=Renu|first4=S.|last5=Anila|first5=K. R.|last6=Sindhu Nair|first6=P.|last7=Priya Kumari|first7=T.|last8=Kusuma Kumary|first8=P.|title=Clinical and Hematological Profile of Acute Megakaryoblastic Leukemia: A 2 Year Study|journal=Indian Journal of Hematology and Blood Transfusion|volume=31|issue=2|year=2014|pages=169–173|issn=0971-4502|doi=10.1007/s12288-014-0413-1}}</ref><ref name="AthaleKaste2002">{{cite journal|last1=Athale|first1=Uma H.|last2=Kaste|first2=Sue C.|last3=Razzouk|first3=Bassem I.|last4=Rubnitz|first4=Jeffrey E.|last5=Ribeiro|first5=Raul C.|title=Skeletal Manifestations of Pediatric Acute Megakaryoblastic Leukemia|journal=Journal of Pediatric Hematology/Oncology|volume=24|issue=7|year=2002|pages=561–565|issn=1077-4114|doi=10.1097/00043426-200210000-00014}}</ref> pallor, generalized pain, temporal swelling, [[bruising]], and difficulty walking.<ref name="AthaleKaste20023">{{cite journal|last1=Athale|first1=Uma H.|last2=Kaste|first2=Sue C.|last3=Razzouk|first3=Bassem I.|last4=Rubnitz|first4=Jeffrey E.|last5=Ribeiro|first5=Raul C.|title=Skeletal Manifestations of Pediatric Acute Megakaryoblastic Leukemia|journal=Journal of Pediatric Hematology/Oncology|volume=24|issue=7|year=2002|pages=561–565|issn=1077-4114|doi=10.1097/00043426-200210000-00014}}</ref>


* Greater than 50% of leukemia patients demonstrate skeletal features and are mostly related to the AMKL subtype.<ref name="AthaleKaste20024">{{cite journal|last1=Athale|first1=Uma H.|last2=Kaste|first2=Sue C.|last3=Razzouk|first3=Bassem I.|last4=Rubnitz|first4=Jeffrey E.|last5=Ribeiro|first5=Raul C.|title=Skeletal Manifestations of Pediatric Acute Megakaryoblastic Leukemia|journal=Journal of Pediatric Hematology/Oncology|volume=24|issue=7|year=2002|pages=561–565|issn=1077-4114|doi=10.1097/00043426-200210000-00014}}</ref>
*Greater than 50% of [[leukemia]] patients demonstrate skeletal features and are mostly related to the AMKL subtype.<ref name="AthaleKaste20024">{{cite journal|last1=Athale|first1=Uma H.|last2=Kaste|first2=Sue C.|last3=Razzouk|first3=Bassem I.|last4=Rubnitz|first4=Jeffrey E.|last5=Ribeiro|first5=Raul C.|title=Skeletal Manifestations of Pediatric Acute Megakaryoblastic Leukemia|journal=Journal of Pediatric Hematology/Oncology|volume=24|issue=7|year=2002|pages=561–565|issn=1077-4114|doi=10.1097/00043426-200210000-00014}}</ref>




Revision as of 03:48, 19 April 2021

  • Greater than 50% of leukemia patients demonstrate skeletal features and are mostly related to the AMKL subtype.[6]



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References

  1. ↑ Zipursky A, Peeters M, Poon A (1987). "Megakaryoblastic leukemia and Down's syndrome: a review". Pediatr Hematol Oncol. 4 (3): 211–30. doi:10.3109/08880018709141272. PMID 2978961.
  2. ↑ Paredes-Aguilera R, Romero-Guzman L, Lopez-Santiago N, Trejo RA (2003). "Biology, clinical, and hematologic features of acute megakaryoblastic leukemia in children". Am J Hematol. 73 (2): 71–80. doi:10.1002/ajh.10320. PMID 12749007.
  3. ↑ Jayasudha, A. V.; Nair, Rekha A.; Jacob, Priya Mary; Renu, S.; Anila, K. R.; Sindhu Nair, P.; Priya Kumari, T.; Kusuma Kumary, P. (2014). "Clinical and Hematological Profile of Acute Megakaryoblastic Leukemia: A 2 Year Study". Indian Journal of Hematology and Blood Transfusion. 31 (2): 169–173. doi:10.1007/s12288-014-0413-1. ISSN 0971-4502.
  4. ↑ Athale, Uma H.; Kaste, Sue C.; Razzouk, Bassem I.; Rubnitz, Jeffrey E.; Ribeiro, Raul C. (2002). "Skeletal Manifestations of Pediatric Acute Megakaryoblastic Leukemia". Journal of Pediatric Hematology/Oncology. 24 (7): 561–565. doi:10.1097/00043426-200210000-00014. ISSN 1077-4114.
  5. ↑ Athale, Uma H.; Kaste, Sue C.; Razzouk, Bassem I.; Rubnitz, Jeffrey E.; Ribeiro, Raul C. (2002). "Skeletal Manifestations of Pediatric Acute Megakaryoblastic Leukemia". Journal of Pediatric Hematology/Oncology. 24 (7): 561–565. doi:10.1097/00043426-200210000-00014. ISSN 1077-4114.
  6. ↑ Athale, Uma H.; Kaste, Sue C.; Razzouk, Bassem I.; Rubnitz, Jeffrey E.; Ribeiro, Raul C. (2002). "Skeletal Manifestations of Pediatric Acute Megakaryoblastic Leukemia". Journal of Pediatric Hematology/Oncology. 24 (7): 561–565. doi:10.1097/00043426-200210000-00014. ISSN 1077-4114.

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