Bovine spongiform encephalopathy laboratory findings: Difference between revisions
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{{Bovine spongiform encephalopathy}} | {{Bovine spongiform encephalopathy}} | ||
{{CMG}} ; {{AE}} {{Adnan Ezici}} | |||
==Overview== | |||
Laboratory findings consistent with the diagnosis of bovine spongiform encephalopathy include the detection of PrPBSE in the brain tissue (either by western blot, ELISA, or ID-Leystad), the detection of Scrapie-Associated Fibrils in the brain tissue (by electron microscopy), and specific histopathologic findings such as vacuolation of [[neurons]] and neuropil. | |||
==Laboratory Findings== | |||
Laboratory findings consistent with the diagnosis of bovine spongiform encephalopathy include:<ref name="pmid11087129">{{cite journal| author=van Keulen LJ, Langeveld JP, Garssen GJ, Jacobs JG, Schreuder BE, Smits MA| title=Diagnosis of bovine spongiform encephalopathy: a review. | journal=Vet Q | year= 2000 | volume= 22 | issue= 4 | pages= 197-200 | pmid=11087129 | doi=10.1080/01652176.2000.9695057 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11087129 }} </ref><ref name="urlMANUAL ON BOVINE SPONGIFORM ENCEPHALOPATHY">{{cite web |url=https://www.fao.org/3/w8656e/w8656e00.htm |title=MANUAL ON BOVINE SPONGIFORM ENCEPHALOPATHY |format= |work= |accessdate=}}</ref> | |||
*Detection of PrPBSE in the brain tissue (either by western blot, ELISA, or ID-Lelystad) | |||
*Vacuolation of [[neurons]] and neuropil in the histopathologic examination of [[medulla oblongata]] specimen | |||
*Detection of Scrapie-Associated Fibrils (by electron microscopy) | |||
==References== | ==References== | ||
Latest revision as of 12:30, 2 January 2022
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Adnan Ezici, M.D[2]
Overview
Laboratory findings consistent with the diagnosis of bovine spongiform encephalopathy include the detection of PrPBSE in the brain tissue (either by western blot, ELISA, or ID-Leystad), the detection of Scrapie-Associated Fibrils in the brain tissue (by electron microscopy), and specific histopathologic findings such as vacuolation of neurons and neuropil.
Laboratory Findings
Laboratory findings consistent with the diagnosis of bovine spongiform encephalopathy include:[1][2]
- Detection of PrPBSE in the brain tissue (either by western blot, ELISA, or ID-Lelystad)
- Vacuolation of neurons and neuropil in the histopathologic examination of medulla oblongata specimen
- Detection of Scrapie-Associated Fibrils (by electron microscopy)
References
- ↑ van Keulen LJ, Langeveld JP, Garssen GJ, Jacobs JG, Schreuder BE, Smits MA (2000). "Diagnosis of bovine spongiform encephalopathy: a review". Vet Q. 22 (4): 197–200. doi:10.1080/01652176.2000.9695057. PMID 11087129.
- ↑ "MANUAL ON BOVINE SPONGIFORM ENCEPHALOPATHY".