B-cell lymphoma classification: Difference between revisions
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==Overview== | ==Overview== | ||
==Classification== | ==Classification== | ||
B-cell lymphomas include both [[Hodgkin's lymphoma]]s and most Non-Hodgkins lymphomas. | B-cell lymphomas include both [[Hodgkin's lymphoma]]s and most Non-Hodgkins lymphomas. | ||
*[[Hodgkin's lymphoma]] may be classified according to the [[World Health Organization|World Health Organisation]] classification system into 2 groups:<ref name="pmid26980727">{{cite journal |vauthors=Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES |title=The 2016 revision of the World Health Organization classification of lymphoid neoplasms |journal=Blood |volume=127 |issue=20 |pages=2375–90 |date=May 2016 |pmid=26980727 |pmc=4874220 |doi=10.1182/blood-2016-01-643569 |url=}}</ref> | |||
**Nodular lymphocyte predominant Hodgkin lymphoma | |||
**Classical Hodgkin lymphoma (includes 4 subtypes) | |||
***Nodular sclerosis classical Hodgkin lymphoma | |||
***Lymphocyte-rich classical Hodgkin lymphoma | |||
***Mixed cellularity classical Hodgkin lymphoma | |||
***Lymphocyte-depleted classical Hodgkin lymphoma | |||
*Non-Hodgkin lymphoma may be classified according to the [[World Health Organization|World Health Organisation]] classification system into 2 groups:<ref name="pmid26980727">{{cite journal |vauthors=Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES |title=The 2016 revision of the World Health Organization classification of lymphoid neoplasms |journal=Blood |volume=127 |issue=20 |pages=2375–90 |date=May 2016 |pmid=26980727 |pmc=4874220 |doi=10.1182/blood-2016-01-643569 |url=}}</ref><ref name="”cancer">National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/publications/pdq</ref> | |||
**B-cell neoplasms | |||
**T-cell and putative NK-cell neoplasms | |||
*Non-Hodgkin lymphoma may also be classified according to rate of growth<ref name="CCS">{{cite web | title = Canadian Cancer Society Grades of non-Hodgkin lymphoma | |||
| url =http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/grading/?region=ab}}</ref> | |||
**High-grade (aggressive) | |||
**Low-grade (indolent) | |||
===Most common=== | ===Most common=== | ||
Revision as of 17:30, 14 January 2022
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Classification
B-cell lymphomas include both Hodgkin's lymphomas and most Non-Hodgkins lymphomas.
- Hodgkin's lymphoma may be classified according to the World Health Organisation classification system into 2 groups:[1]
- Nodular lymphocyte predominant Hodgkin lymphoma
- Classical Hodgkin lymphoma (includes 4 subtypes)
- Nodular sclerosis classical Hodgkin lymphoma
- Lymphocyte-rich classical Hodgkin lymphoma
- Mixed cellularity classical Hodgkin lymphoma
- Lymphocyte-depleted classical Hodgkin lymphoma
- Non-Hodgkin lymphoma may be classified according to the World Health Organisation classification system into 2 groups:[1][2]
- B-cell neoplasms
- T-cell and putative NK-cell neoplasms
- Non-Hodgkin lymphoma may also be classified according to rate of growth[3]
- High-grade (aggressive)
- Low-grade (indolent)
Most common
Five account for nearly three out of four patients with non-Hodgkin lymphoma:[4]
- Diffuse large B cell lymphoma
- Follicular lymphoma
- Mucosa-Associated Lymphatic Tissue lymphoma (MALT)
- Small cell lymphocytic lymphoma (overlaps with Chronic lymphocytic leukemia)
- Mantle cell lymphoma (MCL)
Rare
The remaining forms are much less common:[4]
- Burkitt lymphoma
- Mediastinal large B cell lymphoma
- Waldenström macroglobulinemia
- Nodal marginal zone B cell lymphoma (NMZL)
- Splenic marginal zone lymphoma (SMZL)
- Extranodal marginal zone B cell lymphoma
- Intravascular large B cell lymphoma
- Primary effusion lymphoma
- Lymphomatoid granulomatosis
- T cell/histiocyte-rich large B-cell lymphoma
- Primary central nervous system lymphoma
- Primary cutaneous diffuse large B-cell lymphoma, leg type (Primary cutaneous DLBCL, leg type)
- EBV positive diffuse large B-cell lymphoma of the elderly
- Diffuse large B-cell lymphoma associated with inflammation
- Intravascular large B-cell lymphoma
- ALK-positive large B-cell lymphoma
- Plasmablastic lymphoma
- Large B-cell lymphoma arising in HHV8-associated multicentric Castleman's disease
- B-cell lymphoma, unclassifiable with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma
- B-cell lymphoma, unclassifiable with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma
Others
Additionally, some researchers separate out lymphomas that appear result from other immune system disorders, such as AIDS-related lymphoma.
Classic Hodgkin's lymphoma and nodular lymphocyte predominant Hodgkin's lymphoma are now considered forms of B-cell lymphoma.[5]
References
- ↑ 1.0 1.1 Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES (May 2016). "The 2016 revision of the World Health Organization classification of lymphoid neoplasms". Blood. 127 (20): 2375–90. doi:10.1182/blood-2016-01-643569. PMC 4874220. PMID 26980727.
- ↑ National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/publications/pdq
- ↑ "Canadian Cancer Society Grades of non-Hodgkin lymphoma".
- ↑ 4.0 4.1 "The Lymphomas" (PDF). The Leukemia & Lymphoma Society. May 2006. pp. p. 12. Retrieved 2008-04-07.
- ↑ "HMDS: Hodgkin's Lymphoma". Archived from the original on 4 March 2009. Retrieved 2009-02-01.