Haff disease differential diagnosis

Haff disease Microchapters
Home
Patient Information
Overview
Historical Perspective
Pathophysiology
Causes
Differentiating Haff disease from other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Ultrasound
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Haff disease differential diagnosis On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Haff disease differential diagnosis All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Haff disease differential diagnosis
CDC on Haff disease differential diagnosis
Haff disease differential diagnosis in the news
Blogs on Haff disease differential diagnosis
Directions to Hospitals Treating Haff disease
Risk calculators and risk factors for Haff disease differential diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: M. Hassan, M.B.B.S

Overview

Haff disease causes rhabdomyolysis and must be differentiated from other causes of rhabdomyolysis, which may be categorized as physical, non-physical, and genetic factors. Physical factors include trauma, excessive muscular activity, status epilepticus, high-grade fever, heatstroke, and electric shock. Non-physical factors include medications, infections, drugs, and electrolyte abnormalities. Genetic factors consist of autoimmune diseases, metabolic diseases, and various inherited conditions.

Differential Diagnosis

Haff disease is known to cause rhabdomyolysis, and therefore, it should be differentiated from other causes of rhabdomyolysis. There are numerous etiologies of rhabdomyolysis and they may be categorized based on the physical, non-physical and genetic factors.

Physical factors

• Trauma
• Excessive muscular activity
• Status epilepticus
• High-grade fever
• Heat stroke
• Electric shock

Non-physical factors

• Medication (e.g., anti-retrovirals, anti-histamines, anti-psychotics, antidepressants, and statins)
• Infection (bacterial, and viral)
• Drugs (e.g., alcohol, heroin, cocaine, methamphetamine, ecstasy, and LSD)
• Electrolyte abnormalities (e.g., hypokalemia, hypophosphatemia, hyponatremia, and hypernatremia)

Genetic factors

• Autoimmune diseases (e.g., polymyositis and dermatomyositis)
• Metabolic diseases (e.g., diabetes, thyroid dysfunction, primary hyperaldosteronism, primary adrenal insufficiency, central diabetes insipidus, postpartum hypernatremia, and pituitary dysfunction).
• Inherited conditions (e.g., glycogen storage disorders, fatty acid oxidation disorders, mitochondrial myopathies, muscular dystrophies, and RYR1- related myopathies)