Capillary leak syndrome: Difference between revisions
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==[[Capillary leak syndrome differential diagnosis|Differentiating Capillary leak syndrome from other Diseases]]== | ==[[Capillary leak syndrome differential diagnosis|Differentiating Capillary leak syndrome from other Diseases]]== | ||
As capillary leak syndrome has overlapping clinical and laboratory findings with various other conditions, it should be considered as the diagnosis of exclusion. Several conditions that may be considered as the differential diagnoses of capillary leak syndrome include [https://www.wikidoc.org/index.php/Polycythemia%20vera polycythemia vera], [https://www.wikidoc.org/index.php/Hereditary%20angioedema hereditary angioedema], Gleich syndrome, [https://www.wikidoc.org/index.php/Adrenal%20insufficiency adrenal insufficiency], [https://www.wikidoc.org/index.php/Mast%20cell%20tumor mast cell disease], [https://www.wikidoc.org/index.php/Acute%20gastroenteritis acute gastroenteritis], [https://www.wikidoc.org/index.php/Carcinoid%20syndrome carcinoid syndrome], [https://www.wikidoc.org/index.php/Primary%20amyloidosis primary amyloidosis], [https://www.wikidoc.org/index.php/Chronic%20heart%20failure chronic heart failure], [https://www.wikidoc.org/index.php/Sepsis sepsis], and [https://www.wikidoc.org/index.php/Toxic%20shock%20syndrome toxic shock syndrome]. | |||
==[[Capillary leak syndrome epidemiology and demographics|Epidemiology and Demographics]]== | ==[[Capillary leak syndrome epidemiology and demographics|Epidemiology and Demographics]]== | ||
Revision as of 06:51, 7 August 2022
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: M. Hassan, M.B.B.S
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Capillary leak syndrome Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Capillary leak syndrome On the Web |
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American Roentgen Ray Society Images of Capillary leak syndrome |
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Risk calculators and risk factors for Capillary leak syndrome |
Synonyms and Keywords: Systemic capillary leak syndrome; SCLS; Clarkson's disease.
Overview
Historical Perspective
Capillary leak syndrome was first described by B. Clarkson in 1960, and was named after him.
Numerous case reports on capillary leak syndrome are published since then.
Between 1960 to 2006, a hundred cases of capillary leak syndrome were reported in the world literature, and additional 26 cases were published since 2006.
Pathophysiology
The pathogenesis of capillary leak syndrome remain unclear, however, cytokines, vascular endothelial growth factor (VEGF), leukotrienes, and complement play an important role. During each episode of hyperpermeability of the vasculature, there is an increase of interleukin 2 receptor-positive peripheral blood M-cell count, as well as apoptosis of the endothelial cells.
Causes
Differentiating Capillary leak syndrome from other Diseases
As capillary leak syndrome has overlapping clinical and laboratory findings with various other conditions, it should be considered as the diagnosis of exclusion. Several conditions that may be considered as the differential diagnoses of capillary leak syndrome include polycythemia vera, hereditary angioedema, Gleich syndrome, adrenal insufficiency, mast cell disease, acute gastroenteritis, carcinoid syndrome, primary amyloidosis, chronic heart failure, sepsis, and toxic shock syndrome.
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | Other Diagnostic Studies
Treatment
Medical Therapy | Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies