Capillary leak syndrome: Difference between revisions
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==[[Capillary leak syndrome historical perspective|Historical Perspective]]== | ==[[Capillary leak syndrome historical perspective|Historical Perspective]]== | ||
==[[Capillary leak syndrome pathophysiology|Pathophysiology]]== | ==[[Capillary leak syndrome pathophysiology|Pathophysiology]]== | ||
The pathogenesis of capillary leak syndrome remain unclear, however, '''[https://www.wikidoc.org/index.php/Cytokines cytokines]''', '''[https://www.wikidoc.org/index.php/Vascular_endothelial_growth_factor vascular endothelial growth factor]''' (VEGF), '''[https://www.wikidoc.org/index.php/Leukotrienes leukotrienes]''', and '''complement''' play an important role. During each episode of hyperpermeability of the vasculature, there is an increase of interleukin 2 receptor-positive peripheral blood M-cell count, as well as apoptosis of the endothelial cells. | The pathogenesis of capillary leak syndrome remain unclear, however, '''[https://www.wikidoc.org/index.php/Cytokines cytokines]''', '''[https://www.wikidoc.org/index.php/Vascular_endothelial_growth_factor vascular endothelial growth factor]''' (VEGF), '''[https://www.wikidoc.org/index.php/Leukotrienes leukotrienes]''', and '''complement''' play an important role. During each episode of hyperpermeability of the vasculature, there is an increase of interleukin 2 receptor-positive peripheral blood M-cell count, as well as apoptosis of the endothelial cells. | ||
Revision as of 07:23, 7 August 2022
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: M. Hassan, M.B.B.S
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Capillary leak syndrome Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Capillary leak syndrome On the Web |
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American Roentgen Ray Society Images of Capillary leak syndrome |
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Risk calculators and risk factors for Capillary leak syndrome |
Synonyms and Keywords: Systemic capillary leak syndrome; SCLS; Clarkson's disease.
Overview
Historical Perspective
Pathophysiology
The pathogenesis of capillary leak syndrome remain unclear, however, cytokines, vascular endothelial growth factor (VEGF), leukotrienes, and complement play an important role. During each episode of hyperpermeability of the vasculature, there is an increase of interleukin 2 receptor-positive peripheral blood M-cell count, as well as apoptosis of the endothelial cells.
Causes
Differentiating Capillary leak syndrome from other Diseases
As capillary leak syndrome has overlapping clinical and laboratory findings with various other conditions, it should be considered as the diagnosis of exclusion. Several conditions that may be considered as the differential diagnoses of capillary leak syndrome include polycythemia vera, hereditary angioedema, Gleich syndrome, adrenal insufficiency, mast cell disease, acute gastroenteritis, carcinoid syndrome, primary amyloidosis, chronic heart failure, sepsis, and toxic shock syndrome.
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | Other Diagnostic Studies
Treatment
Medical Therapy | Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies