Capillary leak syndrome causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: M. Hassan, M.B.B.S

Overview

Capillary leak syndrome may be a result of various diseases, and an adverse effect of numerous drugs.

Conditions associated with capillary leak syndrome include sepsis, engraftment syndrome, differentiation syndrome, ovarian hyperstimulation syndrome, hemophagocytic lymphohistiocytosis, viral hemorrhagic fevers, autoimmune disease, snakebite envenomation, and ricin poisoning.

Drugs associated with capillary leak syndrome include Acitretin, Aldesleukin, Denileukin diftitox, Filgastrim, Oprelvekin, Sargramostim, tbo-filgrastim, gemcitabine, and monoclonal antibodies.

Causes

Disease that may cause capillary leak syndrome:

1. Sepsis
2. Engraftment syndrome
3. Differentiation syndrome
4. Ovarian hyperstimulation syndrome
5. Hemophagocytic lymphohistiocytosis
6. Viral hemorrhagic fevers
7. Autoimmune disease
8. Snakebite envenomation
9. Ricin poisoning

Drug that may cause capillary leak syndrome:

• Acitretin
• Aldesleukin
• Denileukin diftitox
• Filgastrim
• Oprelvekin
• Sargramostim
• Tbo-filgrastim
• Gemcitabine
• Monoclonal antibodies