Human respiratory syncytial virus pathophysiology: Difference between revisions
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** Self-inoculation after touching contaminated surfaces<ref name="pmid7252646">{{cite journal| author=Hall CB, Douglas RG| title=Modes of transmission of respiratory syncytial virus. | journal=J Pediatr | year= 1981 | volume= 99 | issue= 1 | pages= 100-3 | pmid=7252646 | doi=10.1016/s0022-3476(81)80969-9 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7252646 }} </ref> | ** Self-inoculation after touching contaminated surfaces<ref name="pmid7252646">{{cite journal| author=Hall CB, Douglas RG| title=Modes of transmission of respiratory syncytial virus. | journal=J Pediatr | year= 1981 | volume= 99 | issue= 1 | pages= 100-3 | pmid=7252646 | doi=10.1016/s0022-3476(81)80969-9 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7252646 }} </ref> | ||
**Infectious sections in form of large-particle aerosols or fomites<ref name="pmid10987726">{{cite journal| author=Hall CB| title=Nosocomial respiratory syncytial virus infections: the "Cold War" has not ended. | journal=Clin Infect Dis | year= 2000 | volume= 31 | issue= 2 | pages= 590-6 | pmid=10987726 | doi=10.1086/313960 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10987726 }} </ref> | **Infectious sections in form of large-particle aerosols or fomites<ref name="pmid10987726">{{cite journal| author=Hall CB| title=Nosocomial respiratory syncytial virus infections: the "Cold War" has not ended. | journal=Clin Infect Dis | year= 2000 | volume= 31 | issue= 2 | pages= 590-6 | pmid=10987726 | doi=10.1086/313960 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10987726 }} </ref> | ||
* The virus infects the ciliated epithelial cells of the respiratory tract, specifically the bronchioles. It may also infect the basal cells, targeting the airway epithelium<ref name="pmid25033192">{{cite journal| author=Persson BD, Jaffe AB, Fearns R, Danahay H| title=Respiratory syncytial virus can infect basal cells and alter human airway epithelial differentiation. | journal=PLoS One | year= 2014 | volume= 9 | issue= 7 | pages= e102368 | pmid=25033192 | doi=10.1371/journal.pone.0102368 | pmc=4102526 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25033192 }} </ref>. | * The virus infects the ciliated epithelial cells of the respiratory tract, specifically the bronchioles. It may also infect the basal cells, targeting the airway epithelium<ref name="pmid25033192">{{cite journal| author=Persson BD, Jaffe AB, Fearns R, Danahay H| title=Respiratory syncytial virus can infect basal cells and alter human airway epithelial differentiation. | journal=PLoS One | year= 2014 | volume= 9 | issue= 7 | pages= e102368 | pmid=25033192 | doi=10.1371/journal.pone.0102368 | pmc=4102526 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25033192 }} </ref>. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Bassel Almarie M.D.[2]
Overview
Transmission
- Respiratory syncytial virus is spread by
- The virus infects the ciliated epithelial cells of the respiratory tract, specifically the bronchioles. It may also infect the basal cells, targeting the airway epithelium[3].
- Upon infection, an intense inflammatory response is triggered, mediated initially by the infected airway epithelial cells[4][5].
Genetics
- RSV is an enveloped, negative sense, single stranded RNA virus. It is member of Pneumoviridae family, Orthopneumovirus genus[5].
- The viral genome encodes 11 proteins. The G protein is responsible for viral attachment to cells, and the F protein promotes syncytia formation[4].
References
- ↑ Hall CB, Douglas RG (1981). "Modes of transmission of respiratory syncytial virus". J Pediatr. 99 (1): 100–3. doi:10.1016/s0022-3476(81)80969-9. PMID 7252646.
- ↑ Hall CB (2000). "Nosocomial respiratory syncytial virus infections: the "Cold War" has not ended". Clin Infect Dis. 31 (2): 590–6. doi:10.1086/313960. PMID 10987726.
- ↑ Persson BD, Jaffe AB, Fearns R, Danahay H (2014). "Respiratory syncytial virus can infect basal cells and alter human airway epithelial differentiation". PLoS One. 9 (7): e102368. doi:10.1371/journal.pone.0102368. PMC 4102526. PMID 25033192.
- ↑ 4.0 4.1 Hacking D, Hull J (2002). "Respiratory syncytial virus--viral biology and the host response". J Infect. 45 (1): 18–24. doi:10.1053/jinf.2002.1015. PMID 12217726.
- ↑ 5.0 5.1 Rey-Jurado E, Kalergis AM (2017). "Immunological Features of Respiratory Syncytial Virus-Caused Pneumonia-Implications for Vaccine Design". Int J Mol Sci. 18 (3). doi:10.3390/ijms18030556. PMC 5372572. PMID 28273842.