POEMS syndrome diagnostic criteria: Difference between revisions
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==Diagnostic Criteria== | ==Diagnostic Criteria== | ||
The most recent criteria for the diagnosis of POEMS syndrome | The most recent criteria for the diagnosis of POEMS syndrome require that all of the following be present: | ||
* [[Polyneuropathy]] | * [[Polyneuropathy]] | ||
* A monoclonal plasma-cell proliferative disorder | * A monoclonal plasma-cell proliferative disorder | ||
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** [[Thrombocytosis]] or [[polycythaemia]] | ** [[Thrombocytosis]] or [[polycythaemia]] | ||
In addition, their study showed a number of associations, the relevance of which to diagnosis was unclear: [[clubbing]], [[weight loss]], | In addition, their study showed a number of associations, the relevance of which to diagnosis was unclear: [[clubbing]], [[weight loss]], and [[hyperhidrosis]]. Possible associations included [[pulmonary hypertension]], restrictive lung disease, a [[thrombophilia|thrombotic diathesis]], [[arthralgia]], [[cardiomyopathy]] (systolic dysfunction), [[fever]], low [[vitamin B12]] levels and [[diarrhea]]. | ||
==References== | ==References== | ||
Revision as of 20:00, 19 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Diagnostic Criteria
The most recent criteria for the diagnosis of POEMS syndrome require that all of the following be present:
- Polyneuropathy
- A monoclonal plasma-cell proliferative disorder
- One or more of the following major criteria:
- Sclerotic bone lesions
- Castleman's disease
- Elevated VEGF levels
- One or more of the following minor criteria:
- Organomegaly (enlarged spleen, liver or lymph nodes)
- Extravascular volume overload (oedema, pleural effusion or ascites)
- Endocrinopathy (adrenal, pituitary, gonadal, parathyroid); diabetes or hypothyroidism alone are insufficient
- Skin changes
- Papilloedema
- Thrombocytosis or polycythaemia
In addition, their study showed a number of associations, the relevance of which to diagnosis was unclear: clubbing, weight loss, and hyperhidrosis. Possible associations included pulmonary hypertension, restrictive lung disease, a thrombotic diathesis, arthralgia, cardiomyopathy (systolic dysfunction), fever, low vitamin B12 levels and diarrhea.