Hemophilia A causes: Difference between revisions
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{{Hemophilia A}} | {{Hemophilia A}} | ||
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==Overview== | |||
==Causes== | |||
[[Hemophilia B]] is caused by an inherited [[X-linked]] [[recessive trait]], with the defective [[gene]] located on the [[X chromosome]]. | |||
Females have two copies of the [[X chromosome]], so if the [[factor IX]] [[gene]] on one [[chromosome]] is defective, the [[gene]] on the other [[chromosome]] can do the job of making enough [[factor IX]]. | |||
Males, however, have only one [[X chromosome]], so if the [[factor IX]] [[gene]] on that [[chromosome]] is defective, they will have [[Hemophilia B]]. Therefore, most people with [[hemophilia B]] are male. | |||
If a woman has a defective [[factor IX]] [[gene]], she is considered a carrier. This means the defective [[gene]] can be passed down to her children. | |||
Boys born to a woman who carries the defective [[gene]] have a 50% chance of having [[hemophilia B]], while their daughters have a 50% chance of being a carrier. | |||
All female children of men with [[hemophilia]] carry the defective [[gene]]. | |||
==References== | ==References== | ||
Revision as of 15:25, 21 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
Hemophilia B is caused by an inherited X-linked recessive trait, with the defective gene located on the X chromosome.
Females have two copies of the X chromosome, so if the factor IX gene on one chromosome is defective, the gene on the other chromosome can do the job of making enough factor IX.
Males, however, have only one X chromosome, so if the factor IX gene on that chromosome is defective, they will have Hemophilia B. Therefore, most people with hemophilia B are male.
If a woman has a defective factor IX gene, she is considered a carrier. This means the defective gene can be passed down to her children.
Boys born to a woman who carries the defective gene have a 50% chance of having hemophilia B, while their daughters have a 50% chance of being a carrier.
All female children of men with hemophilia carry the defective gene.