Hemophilia A laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Laboratory Findings

The diagnosis may be suspected as coagulation testing reveals an increased PTT in the context of a normal PT and bleeding time. The diagnosis is made in the presence of very low (<10 IU) levels of factor VIII. A very small minority of patients has antibodies against factor VIII that impair its functioning. Management of these patients is more complicated.

• Prolonged partial thromboplastin time (PTT)
• Normal prothrombin time
• Normal bleeding time
• Normal fibrinogen level
• Low factor IX